Emerg Infect DisEmerging Infect. DisEIDEmerging Infectious Diseases1080-60401080-6059Centers for Disease Control and Prevention15496252332042703-110710.3201/eid1008.031107DispatchDispatchSyphilis in the HIV EraSyphilis in the HIV EraKassuttoSigall*DoweikoJohn P.*Beth Israel Deaconess Medical Center, Boston, Massachusetts, USAAddress for correspondence: Sigall Kassutto, Beth Israel Deaconess Medical Center, Division of Infectious Diseases, 110 Francis Street, Boston, MA 02215, USA; fax: 617-632-7626; email: skassutt@bidmc.harvard.edu8200410814711473

The incidence of syphilis has consistently increased from 2000 to 2002. We report a case of acquired syphilis with symptoms of Tullio phenomenon in a patient concurrently diagnosed with HIV infection. The resurgence of syphilis in HIV-positive groups at high risk has public health implications for prevention of both diseases.

Keywords: syphilisepidemiologyTullio phenomenonHIVMSMdispatch
The Case

A 35-year-old man with an unremarkable medical history sought treatment for headaches, hearing loss, and night sweats. The headaches were occipital and bilateral and had started 3 months earlier. They came on as the day progressed and were neither positional nor associated with nausea, vomiting, or visual changes. Three weeks before arriving at the hospital, he noted a sense of "fullness" in his ears; he said that spoken voices sounded muffled, and he had difficulty hearing telephone conversations. When someone at the restaurant where he worked dropped a dish, he heard that sound clearly and reported that it was almost painful, causing him to become dizzy. He otherwise denied ear pain or recent trauma. His appetite was good, and he had not lost weight. Although he reported no fever, he did report night sweats for several weeks. He had no rash, diarrhea, abdominal pain, chest pain, shortness of breath, joint complaints, or dysuria. The patient attributed his headaches to stress. He also said that he was exposed to dust at his workplace because of remodeling.

The patient was taking no regular medications and had no drug allergies. He had quit smoking 7 months earlier and drank 10–12 beers per week. He reported no history of intravenous drug use. He lived in New Hampshire, had no pets, and worked as part owner of a restaurant. Exposures included multiple male and female sexual partners with inconsistent condom use, and he had acquired several tattoos 8 months earlier while traveling in Spain and Italy. He had no known tuberculosis exposure. An HIV antibody test had been negative 18 months earlier.

On physical examination, he appeared healthy but anxious. Temperature was 36.7°C, blood pressure 128/84 mm Hg, pulse 80, respirations 16/minute. Sclerae were anicteric, and his pupils reacted to direct and consensual testing and responded normally to accommodation. Funduscopic examination showed no retinal abnormalities. The left tympanic membrane was retracted; both sides demonstrated a small effusion. No vesicles were seen. Bedside testing showed that his hearing was diminished to low volume sounds, but he was able to hear loud sounds, which he found painful. When the examiner clapped his hands loudly a few feet from the patient's ear, the patient exhibited nystagmus. His sinuses were not tender, and the oral mucosa had no lesions. The patient's neck was supple; a 1.5-cm, nontender lymph node was palpated in the left upper anterior cervical chain. No other lymphadenopathy was noted. The remainder of the examination was unremarkable, with negative Romberg test; normal gait; and normal motor, sensory, and reflex performance.

Laboratory evaluation (Table) showed low hematocrit and normal renal and liver function. HIV enzyme-linked immunosorbent assay and confirmatory test were positive. Rapid plasma reagin (RPR) was positive at a titer of 1:128 and was confirmed by a fluorescent treponemal antibody test. Subsequent studies showed a CD4 receptor–positive T-cell (CD4) count of 899/mL and an HIV viral load of 878 copies/mL. A lumbar puncture showed protein 33 mg/dL, glucose 78 mg/dL, 9 erythrocytes/µL, and 8 leukocytes/µL (100% lymphocytes). Cerebrospinal fluid venereal disease research laboratory test (CSF-VDRL) results were negative.

Selected laboratory test results 1 month after therapy for neurosyphilis in HIV-positive patient with neurosyphilis<sup>a</sup>
Laboratory testResult
Complete blood count
Leukocytes5,700/µL
Hematocrit36%
Platelets295,000/µL
Electrolytes and renal function testsWithin normal limits
Liver function testsWithin normal limits
Cerebrospinal fluid evaluation
Leukocytes8 cells/µL
Differential100% lymphocytes
Erythrocytes9 cells/µL
Protein33 mg/dL
Glucose78 mg/dL
CSF-VDRLNegative
HIV-1 testing
ELISA + WBPositive
CD4 count899 cells/µL
Viral load (RT-PCR)878 copies/mL
Rapid plasma reagin testing
Baseline1:128
1 month posttreatment1:32
3 months posttreatmentNonreactive

aCSF-VDRL, cerebrospinal fluid venereal disease research laboratory test; ELISA, enzyme-linked immunosorbent assay; WB, Western blot; RT-PCR, reverse transcription–polymerase chain reaction.

The patient was started on 24 mU of IV penicillin per day for 14 days. At the end of this period, he reported notable improvement in his headaches, hearing loss, and vertiginous symptoms. One month after completing treatment, his RPR titer was 1:32; 3 months after he completed treatment, it was nonreactive.

Conclusions

The course of syphilis in an HIV-positive patient may be altered from the natural history of the disease in HIV-negative patients. An increased frequency of ocular disease, multiple and slower resolving primary chancres, and a higher titer RPR have been reported (16). In addition, delay or failure of titer decline after treatment, predilection for developing the Jarisch-Herxheimer reaction, and clinical relapse have also been described in HIV infection (1,4,7,8).

Treponema pallidum is thought to invade the central nervous system in 25% of patients with syphilis, irrespective of HIV status (9). Most of these persons successfully clear the infection (10), but other patients harbor the spirochete and remain at risk for sequelae of neurosyphilis. Syphilitic meningitis, meningovascular disease (often occurring with stroke), labyrinthitis, or cranial nerve palsies, as seen in this case, can be early findings.

The Tullio phenomenon is vestibular hypersensitivity to sound. In this condition, loud sounds or even routine acoustic stimuli can result in vertigo, nystagmus, or nausea and vomiting. The physiologic underpinnings of the Tullio phenomenon were first described in 1929, when Tullio noted that experimentally induced fenestrations in the bony capsule of the lateral semicircular canals of pigeons caused the canals to be sound-responsive, inducing vestibular activation (11,12). Shortly thereafter, Benjamins described a Tullio reaction in a human patient with fistulizing cholesteatoma (13). Today, the term has been generalized to include vestibular activation in response to stimulation by sound of any part of the vestibular apparatus (12).

The Tullio phenomenon is seen in a range of clinical contexts, including congenital deafness, Meniere disease, suppurative middle ear disease, and spirochetal infections, such as syphilis or Lyme disease. Nields et al. describe a woman who had nystagmus and vertigo with routine sounds; running tap water caused her to fall to the floor or retch in pain (14). Watson et al. describe a series of patients with oscillopsia induced by pencil tapping, telephone ringing, or the sound of cutlery falling on the floor. Patients often report a vague sense of ear blockage and an unpleasant awareness of their own voice vibrating in their ear (12).

Symptomatic cranial nerve VIII involvement in this patient prompted treatment for neurosyphilis, despite equivocal (but typical) CSF findings. Interpreting CSF findings in HIV-positive patients with syphilis is challenging because commonly encountered mild lymphocytic pleocytosis may be attributable to HIV. CSF-VDRL is often negative, with a 20%–70% false-negative rate (15).

Optimally managing patients with HIV and syphilis has been debated; to date routine recommendations are the same as for HIV-negative persons (16). Although any patient in whom syphilis is diagnosed and who has neurologic symptoms should undergo lumbar puncture, CSF evaluation should also be considered in asymptomatic patients in whom syphilis is diagnosed and who have an RPR titer >1:32 or a CD4+ count <350, as these markers have been associated with increased risk for neurosyphilis (10). Because of the high rate of relapse that has been reported in some series (4,7,8), close clinical and serologic follow-up is essential. Whether T. pallidum eradication is impaired in HIV coinfection remains controversial. A study of 59 patients with neurosyphilis showed that HIV-positive study participants were 2.5 times less likely to normalize CSF-VDRL reactivity than HIV-negative patients. This effect was even more pronounced in patients with CD4+ counts <200 (17). The findings suggest that more intensive therapy for neurosyphilis in immunocompromised patients merits further study.

After an all-time low case-rate of syphilis in 2000, reports of rising trends, specifically in groups at risk, such as men who have sex with men, were reported in 2001 (18). The outbreaks marked a 9.1% overall increased rate of primary and secondary syphilis (19) and were characterized by a high rate of HIV infection. Parallel increases in HIV infection rates were a concern because of the common mechanism of transmission and the increased efficiency of HIV transmission with coexistent genital ulcers (20). In 2001, increases in HIV rates were reported in several states with large urban populations; men who have sex with men accounted for the largest known subgroup at risk in incident adult or adolescent HIV cases (32%) and AIDS cases (44%) (21). New HIV diagnoses increased in 29 states with mandatory reporting from 1999 to 2002, notably by 17% among gay and bisexual men (22). Syphilis incidence also continued to rise in the United States in 2002, with a 12.4% increase since 2001 (19), and the highest trends were estimated to be among men who have sex with men. In San Francisco, primary and secondary syphilis rates increased by >1,000% from 1998 to 2002 among men who have sex with men (23). High-risk behaviors have been documented in this group (24) and factor prominently in syphilis reemergence in the early 21st century.

This case report describes a patient who had Tullio phenomenon as the index symptom of neurosyphilis with previously undiagnosed HIV infection. His RPR titer was 1:128, his CD4 count was preserved, and he responded well clinically and serologically to standard therapy. To our knowledge, this case is the first report of syphilis occurring as Tullio phenomenon in an HIV-positive patient. We suggest that syphilis be considered in patients who have cranial nerve VIII symptoms and an appropriate risk-factor profile. Eradicating treponemes may be limited from sanctuary sites such as the CNS. Because control of syphilis likely depends not only on antimicrobial effect but also on host immune response, routine surveillance is a mainstay of therapy, particularly in patients with HIV infection. Awareness of unusual symptoms of a relatively common disease will benefit not only the patient but also public health efforts in managing both syphilis and HIV infection. Preventive and educational efforts focused on men who have sex with men may prove particularly important in modifying behaviors that foster the growth of both epidemics.

Suggested citation for this article: Kassutto S, Doweiko JP. Syphilis in the HIV era. Emerg Infect Dis [serial on the Internet]. 2004 Aug [date cited]. http://dx.doi.org/10.3201/eid1008.031107

Dr. Kassutto is a fellow in Infectious Diseases at Beth Israel Deaconess Medical Center. Her clinical interests are HIV disease, opportunistic infections, and tropical medicine. Her research interests are in acute HIV-1 infection.

Dr. Doweiko is a clinician-educator practicing HIV medicine and clinical hematology at Beth Israel Deaconess Medical Center. His interests are AIDS oncology, general hematology, and HIV.

ReferencesKatz DA, Berger JR, Duncan RC Neurosyphilis: a comparative study of the effects of infection with the human immunodeficiency virus. Arch Neurol. 1993;50:2439 10.1001/archneur.1993.005400300090068442701Holtom PD, Larsen RA, Leal ME, Leedom JM Prevalence of neurosyphilis in human immunodeficiency virus-infected patients with latent syphilis. Am J Med. 1992;93:912 10.1016/0002-9343(92)90673-Y1626576Hook EW III, Marra CM Acquired syphilis in adults. N Engl J Med. 1992;326:10609 10.1056/NEJM1992041632616061549153Malone JL, Wallace MR, Hendrick BB, Larocco A Jr, Tonon E, Brodine SK, Syphilis and neurosyphilis in a human immunodeficiency virus type-1 seropositive population: evidence for frequent serologic relapse after therapy. Am J Med. 1995;99:55 10.1016/S0002-9343(99)80105-37598143Hutchinson CM, Hook EW III, Shepherd M, Verley J, Rompalo AM Altered clinical presentation of early syphilis in patients with human immunodeficiency virus infection. Ann Intern Med. 1994;121:941007912483Musher DM, Hamill RJ, Baughn R Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment. Ann Intern Med. 1990;113:872812240901Berry CD, Hooton TM, Collier AC, Lukehart SA Neurologic relapse after benzathine penicillin therapy for secondary syphilis in a patient with HIV infection. N Engl J Med. 1987;316:15879 10.1056/NEJM1987061831625073587291Gordon SM, Eaton ME, George R, Larsen S, Lukehart SA, Kuypers J, The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection. N Engl J Med. 1994;331:146973 10.1056/NEJM1994120133122017969296Rolfs RT, Joesoef MR, Hendershot EF, Rompalo AM, Augenbraun MH, Chin M, A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. N Engl J Med. 1997;337:30714 10.1056/NEJM1997073133705049235493Marra CM, Maxwell CL, Smith SL, Lukehart SA, Rompalo AM, Eaton M, Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features. J Infect Dis. 2004;189:36976 10.1086/38122714745693Tullio P Das Ohr und die Entstehung der Sprache und Schrift. Berlin: Urban and Schwarzenberg; 1929Watson S, Halmagyi GM, Colebatch JG Vestibular hypersensitivity to sound (Tullio phenomenon). Neurology. 2000;54:722810680810Benjamins CE Les réactions acoustique de Tullio chez l'homme. Acta Otolaryngol. 1938;26:249 10.3109/00016483809118444Nields JA, Kveton JF Tullio phenomenon and seronegative Lyme borreliosis. Lancet. 1991;338:1289 10.1016/0140-6736(91)90130-H1676464Singh AE, Romanowski B Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. Clin Microbiol Rev. 1999;12:18720910194456Centers for Disease Control and Prevention Sexually transmitted diseases treatment guidelines—2002. MMWR Morb Mortal Recomm Rep. 2002;51(RR-06):1Marra CM, Maxwell CL, Tantalo L, Eaton M, Rompalo AM, Raines C, Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: does HIV status matter? Clin Infect Dis. 2004;38:10016 10.1086/38253215034833Centers for Disease Control and Prevention Primary and secondary syphilis—United states, 2000–2001. MMWR Morb Mortal Wkly Rep. 2002;51:971312433021Centers for Disease Control and Prevention Primary and secondary syphilis—United States, 2002. MMWR Morb Mortal Wkly Rep. 2003;52:11172014627949Fleming DT, Wasserheit JN From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect. 1999;75:317 10.1136/sti.75.1.310448335Centers for Disease Control and Prevention HIV surveillance [monograph on the Internet]. [cited 2004 June 8]. Available from: http://www.cdc.gov/hiv/surveillance/resources/reports/2001report_no2/Centers for Disease Control and Prevention Increases in HIV diagnoses—29 states, 1999–2002. MMWR Morb Mortal Wkly Rep. 2003;52:1145814647015Buchacz K, Kellogg T, McFarland W, Kohn R, Killey J, Louie B, Trends in primary and secondary syphilis and HIV seroincidence among men who have sex with men in San Francisco, 1998–2002. 11th Conference on Retroviruses and Opportunistic Infections, San Francisco 2004 Feb 8–11; Abstract #88.Koblin BA, Chesney MA, Husnik MJ, Bozeman S, Celum CL, Buchbinder S, High-risk behaviors among men who have sex with men in 6 U.S. cities: baseline data from the EXPLORE study. Am J Public Health. 2003;93:926 10.2105/AJPH.93.6.92612773357