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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="1.3" xml:lang="en" article-type="research-article"><?properties manuscript?><processing-meta base-tagset="archiving" mathml-version="3.0" table-model="xhtml" tagset-family="jats"><restricted-by>pmc</restricted-by></processing-meta><front><journal-meta><journal-id journal-id-type="nlm-journal-id">101084640</journal-id><journal-id journal-id-type="pubmed-jr-id">28447</journal-id><journal-id journal-id-type="nlm-ta">J Off Stat</journal-id><journal-id journal-id-type="iso-abbrev">J Off Stat</journal-id><journal-title-group><journal-title>Journal of official statistics</journal-title></journal-title-group><issn pub-type="ppub">0282-423X</issn><issn pub-type="epub">2001-7367</issn></journal-meta><article-meta><article-id pub-id-type="pmid">36157569</article-id><article-id pub-id-type="pmc">9490791</article-id><article-id pub-id-type="doi">10.2478/jos-2022-0038</article-id><article-id pub-id-type="manuscript">HHSPA1807439</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Variable inclusion strategies through directed acyclic graphs to adjust health surveys subject to selection bias for producing national estimates</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yan</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="CR1" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Irimata</surname><given-names>Katherine E.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Yulei</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Parker</surname><given-names>Jennifer</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Joint Program in Survey Methodology, Department of Epidemiology and Biostatistics, 1218 Lefrak Hall, University of Maryland College Park, College Park, MD 20742</aff><aff id="A2"><label>2</label>Division of Research and Methodology, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782</aff><author-notes><corresp id="CR1">
<label>*</label>
<email>yli6@umd.edu</email>
</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>5</month><year>2022</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2022</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2023</year></pub-date><volume>38</volume><issue>3</issue><fpage>875</fpage><lpage>900</lpage><abstract id="ABS1"><p id="P1">Along with the rapid emergence of web surveys to address time-sensitive priority topics, various propensity score (PS)-based adjustment methods have been developed to improve population representativeness for nonprobability- or probability-sampled web surveys subject to selection bias. Conventional PS-based methods construct pseudo-weights for web samples using a higher-quality reference probability sample. The bias reduction, however, depends on the outcome and variables collected in both web and reference samples. A central issue is identifying variables for inclusion in PS-adjustment. In this paper, directed acyclic graph (DAG), a common graphical tool for causal studies but largely under-utilized in survey research, is used to examine and elucidate how different types of variables in the causal pathways impact the performance of PS-adjustment. While past literature generally recommends including all variables, our research demonstrates that only certain types of variables are needed in PS-adjustment. Our research is illustrated by NCHS&#x02019; Research and Development Survey, a probability-sampled web survey with potential selection bias, PS-adjusted to the National Health Interview Survey, to estimate U.S. asthma prevalence. Findings in this paper can be used by National Statistics Offices to design questionnaires with variables that improve web-samples&#x02019; population representativeness and to release more timely and accurate estimates for priority topics.</p></abstract><kwd-group><kwd>kernel weighting</kwd><kwd>logistic regression</kwd><kwd>propensity score model</kwd><kwd>survey inference</kwd></kwd-group></article-meta></front><body><sec id="S1"><label>1.</label><title>Introduction</title><p id="P2">Producing timely data is a priority of National Statistics Offices (NSOs). However, some of the more timely data collections, including web-based surveys, may be subject to biases relative to large nationally representative surveys conducted by NSOs due to lower coverage and response rates. Adjusting these timelier sources with less timely but higher quality reference surveys may decrease their biases.</p><p id="P3">Selection bias has been acknowledged in different areas (<xref rid="R12" ref-type="bibr">Hern&#x000e1;n 2004</xref>) and is becoming more critical in the big data era with the rapid emergence of various web surveys to address time-sensitive priority topics, referred to here as target samples. Data collected in target samples, such as web panels, can result in attrition and response rates are often found to be 10% or lower (<xref rid="R3" ref-type="bibr">Baker et al., 2013</xref>). Although low response is not necessarily indicative of response bias (<xref rid="R11" ref-type="bibr">Groves and Peytcheva, 2008</xref>; <xref rid="R5" ref-type="bibr">Brick and Tourangeau, 2017</xref>), selection bias has been of great concern because the composition of web panels often differs from that of the underlying population. Panel members tend to be more educated and to have higher socioeconomic status than non-panel-members (<xref rid="R42" ref-type="bibr">Craig et al., 2013</xref>). Epidemiologic target samples often recruit &#x0201c;healthy volunteers&#x0201d; with lower estimates of disease incidence and mortality that a general population (<xref rid="R32" ref-type="bibr">Pinsky et al., 2007</xref>). To reduce the selection bias of the target samples, various propensity score (PS)-based adjustment methods have been developed which use an existing high-quality probability sample (e.g., national representative surveys) as a reference, where high quality refers to probability-sampled surveys with relatively low sampling and non-sampling errors that lead to confidence in their ability to produce representative estimates (<xref rid="R9" ref-type="bibr">Groves, 1989</xref>). Recent PS adjustment methods include, but are not limited to, PS weighting (<xref rid="R36" ref-type="bibr">Valliant, 2020</xref>; <xref rid="R6" ref-type="bibr">Chen et al., 2019</xref>) and PS matching (<xref rid="R16" ref-type="bibr">Kern et al., 2020</xref>) methods.</p><p id="P4">The amount of bias reduction, however, varies depending on the outcome and variables that are collected in both the target and reference data sources. <xref rid="R37" ref-type="bibr">Wang et al. (2020a)</xref> studied the bias reduction of different PS adjustment methods using the non-representative U.S. National Institutes of Health&#x02013;American Association of Retired Persons cohort (<xref rid="R26" ref-type="bibr">NIH-AARP, 2006</xref>), with the National Health Interview Survey (NHIS) as the reference survey. Among the ten selected diseases examined, they found the amount of relative bias reduction ranged from 8% to 30% using their proposed PS-based kernel weighting (KW) method. There is still a large amount of bias that is not removable by PS adjustment methods alone due to the uncollected information in the reference probability sample. The effectiveness of PS adjustment methods depends on the identification of the proper set of covariates, their availability, and their quality (<xref rid="R3" ref-type="bibr">Baker et al., 2013</xref>). Some references (e.g., <xref rid="R27" ref-type="bibr">Mercer et al. 2018</xref>) have even argued that choosing the correct variables can be more important than choosing the correct adjustment models, including PS methods.</p><p id="P5">High-quality probability samples surveyed through well-designed questionnaires are in great demand as reference surveys for at least two reasons: 1) Different PS adjustment methods, including PS-based weighting and matching methods, require a high-quality probability sample as the reference in order to create a set of pseudo-weights for the target sample to better represent the underlying target population; 2) Different target samples may use a common high-quality probability sample as the reference for cost efficiency by using the same questions with exact wordings to avoid potential reporting/measurement error. Given a high-quality population representative reference survey, we are interested in identifying the types of variables that are critical for collection in the target sample to improve its external validity in estimating population quantities. The findings can be used in turn to plan for future surveys.</p><p id="P6">The target sample motivating this research is collected through the National Center for Health Statistics&#x02019; (NCHS) Research and Development Survey (RANDS), a probability-based panel survey that has been conducted using online and phone administration (<ext-link xlink:href="https://www.cdc.gov/nchs/rands" ext-link-type="uri">https://www.cdc.gov/nchs/rands</ext-link>). Although the RANDS data are more structured than nonprobability samples, RANDS is subject to potential selection bias as RANDS has lower response rates, as well as potential measurement and coverage errors compared to traditional interviewer-administered national population health surveys (<xref rid="R29" ref-type="bibr">Parker et al., 2020</xref>). On the other hand, probability survey panels such as RANDS have the potential to produce more timely information than national population surveys. To reduce the potential selection bias in RANDS estimates, NCHS&#x02019; NHIS has been used as a reference sample to construct pseudo-weights using PS-based weighting methods (<xref rid="R29" ref-type="bibr">Parker et al., 2020</xref>; <xref rid="R14" ref-type="bibr">Irimata et al., 2020</xref>) and raking. These adjustments have been applied to the estimation of several population health outcomes, including diagnosed asthma, diagnosed hypertension, diagnosed diabetes, health insurance, as well as for health outcomes related to the coronavirus disease 2019 (COVID-19) pandemic such as access to health care. In these studies, adjustment to the NHIS (PS-based weighting or raking) has typically been performed using the main effects for all common covariates between RANDS and the NHIS, including sociodemographic, health, and internet use variables; the adjustment for RANDS during COVID-19 used a limited subset of variables for the public release of COVID-19-related estimates (<ext-link xlink:href="https://www.cdc.gov/nchs/covid19/rands.htm" ext-link-type="uri">https://www.cdc.gov/nchs/covid19/rands.htm</ext-link>). While PS weighting and raking adjustments have been shown to improve RANDS estimates relative to those without any adjustment to the NHIS (<xref rid="R29" ref-type="bibr">Parker et al., 2020</xref>; <xref rid="R14" ref-type="bibr">Irimata et al., 2020</xref>), stability of the estimated propensity scores and how the inclusion of different variables in the propensity model or calibration affects bias and efficiency of the estimated population mean for various outcomes have been a major concern.</p><p id="P7">Propensity model variable inclusion has been widely studied in different areas, including clinical trial or medical research and survey research. In clinical trial research, participants are included for clinical and experimental purposes (mainly for treatment effect estimation) and are not necessarily representative of the U.S. population. Simulations (<xref rid="R4" ref-type="bibr">Brookhart et al., 2006</xref>; <xref rid="R20" ref-type="bibr">Leyrat et al., 2013</xref>) were performed to examine the effect of the choice of variables that are included in a propensity model has on the bias, variance, and mean squared error of estimated treatment effects. It was concluded that omitting confounding factors increases bias and the inclusion of variables that are independent of the exposure but related to the outcome in the propensity model gains efficiency without increasing bias of estimated treatment effects. However, covariate inclusion for propensity score models in clinical trial research has been limited. <xref rid="R1" ref-type="bibr">Ali et al. (2015)</xref> provided a systematic review of covariate inclusion in the PS model for medical studies and concluded that the quality of reporting variable inclusion is far from optimal in the medical literature. Similarly, <xref rid="R8" ref-type="bibr">Grose et al. (2020)</xref> found 90% out of 303 systematically reviewed studies did not provide justification for covariates included in their PS models.</p><p id="P8">In survey research, propensity analyses have been conducted to estimate response propensity (<xref rid="R10" ref-type="bibr">Groves, 2006</xref>; <xref rid="R13" ref-type="bibr">Iannacchione et al., 1991</xref>) and to adjust sampling weights in representative surveys to reduce the estimation bias due to unit nonresponse. The best auxiliary variables to be included for nonresponse adjustment are those simultaneously correlated with response propensity and the key survey outcomes (<xref rid="R19" ref-type="bibr">Lessler and Kalsbeek, 1992</xref>). <xref rid="R23" ref-type="bibr">Little and Vartivarian (2005)</xref> further suggested that most important feature of variables for inclusion is that the variables are predictive of survey outcomes; prediction of response propensity is a secondary, though useful, goal.</p><p id="P9">This paper, in contrast to the interest of estimating treatment effects in clinical research, aims to estimate population quantities such as the population mean. We are interested in identifying key auxiliary information in a reference probability survey to improve the external validity of inferences from a target dataset. This is an important obligation for survey designers because the choice and inclusion of these variables has a tremendous effect on both the bias and the precision of the estimates of population quantities. This differs from the goal of nonresponse adjustment which uses chosen covariates for predicting response propensities as, in nonresponse adjustment research, respondents are nested within the sampled units, and respondents and nonrespondents share common sampling design variables. As a result, unweighted analysis of response propensity can be performed conditional on the design and response predictive variables (<xref rid="R22" ref-type="bibr">Little and Vartivarian, 2003</xref>). However, this is not true for estimating the propensity of target sample inclusion because the reference survey and the target samples are often independent without sharing design variables (<xref rid="R39" ref-type="bibr">Wang et al., 2021</xref>). Variable choice for the propensity model used to predict the target sample inclusion propensity should be performed with additional care.</p><p id="P10">This paper aims to examine how different types of variables included in a propensity model impact the performance of population mean estimation using target samples through the directed acyclic graph (DAG), a common graphical tool in causal studies but largely under-utilized in survey research. The DAG is used to identify certain types of variables in the causal pathway to be included in the PS model which results in the lowest bias and highest precision under various scenarios. Estimated population means and their variances are evaluated analytically and numerically under various mis-specified propensity models, including with and without interactive effects. Different levels of variable correlations in the finite population are considered to mimic real data scenarios. The findings are applied to RANDS, with NHIS as the reference, to estimate the prevalence of asthma in the U.S. The RANDS evaluation demonstrates the advantage of this approach compared to the approach when the propensity model includes all available variables.</p><p id="P11">The results from this research provide insight for data analysts on propensity model construction to improve the population representativeness of target samples. It also provides insight for questionnaire designers on the critical auxiliary information to collect from the reference survey. NSOs, using the paper results, can design the questionnaires for both the target and reference surveys and release accurate estimates for priority topics from more timely data sources.</p></sec><sec id="S2"><label>2.</label><title>Methods</title><p id="P12">We first introduce some notation. Suppose Y is a binary outcome of interest (e.g., for estimating the prevalence of a disease or health condition: Y=1 if event and 0 otherwise). In the context of survey sampling, suppose A is the binary selection indicator variable (i.e., A=1 if a population unit participates in the target sample and 0 otherwise). Note A indicates the target sample participation with value of one representing population units who are recruited and respond to the survey.</p><p id="P13">We adapt the framework of <xref rid="R4" ref-type="bibr">Brookhart et al. (2006)</xref> of employing a directed acyclic graph (DAG) to study potential selection bias induced by three types of covariates (see <xref rid="F1" ref-type="fig">Figure 1a</xref>):</p><list list-type="order" id="L2"><list-item><p id="P14">variables related to both the outcome Y and the selection indictor A of the target sample &#x02014; confounders (<italic toggle="yes">X</italic><sub>1</sub>);</p></list-item><list-item><p id="P15">variables related to Y but not related to A &#x02013; outcome predictors (<italic toggle="yes">X</italic><sub>2</sub>);</p></list-item><list-item><p id="P16">variables related to A but not related to Y &#x02013; selection variables (<italic toggle="yes">X</italic><sub>3</sub>).</p></list-item></list><p id="P17">We now present some background about PS adjustment methods. For estimation of the finite population (FP) mean of a binary outcome <italic toggle="yes">E</italic>(<italic toggle="yes">Y</italic>) = <italic toggle="yes">p</italic>(<italic toggle="yes">Y</italic> = 1), the na&#x000ef;ve unweighted estimate using the selected target sample (<italic toggle="yes">A</italic> = 1) has bias relative to the FP, given by <italic toggle="yes">Bias</italic> = <italic toggle="yes">p</italic>(<italic toggle="yes">Y</italic> = 1&#x02223;<italic toggle="yes">A</italic> = 1) &#x02212; <italic toggle="yes">p</italic>(<italic toggle="yes">Y</italic> = 1) = (<italic toggle="yes">R</italic> &#x02212; 1)<italic toggle="yes">p</italic>(<italic toggle="yes">Y</italic> = 1) with <inline-formula><mml:math id="M11" display="inline"><mml:mrow><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>A</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo stretchy="false">&#x02223;</mml:mo><mml:mi>Y</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mrow><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>A</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac></mml:mrow></mml:math></inline-formula>. In order to remove the bias, it requires the conditional distribution of A given Y is the same as the distribution of A, denoted by <italic toggle="yes">A</italic> &#x022a5; <italic toggle="yes">Y</italic> and adjustment methods based on PS are often employed (<xref rid="R36" ref-type="bibr">Valliant 2020</xref>).</p><p id="P18">More specifically in PS-based adjustment methods, the population mean <italic toggle="yes">&#x003bc;</italic> of the outcome Y, is estimated by
<disp-formula id="FD1">
<label>(1)</label>
<mml:math id="M1" display="block"><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mo>=</mml:mo><mml:mfrac><mml:mn>1</mml:mn><mml:mrow><mml:msub><mml:mo>&#x02211;</mml:mo><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:msub><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac><mml:munder><mml:mo>&#x02211;</mml:mo><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:munder><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:msub><mml:mi>y</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>,</mml:mo></mml:mrow></mml:math>
</disp-formula>
where <italic toggle="yes">S<sub>c</sub></italic> denotes the set of sample units in the target sample of size <italic toggle="yes">n<sub>c</sub></italic>; <italic toggle="yes">y<sub>i</sub></italic> for <italic toggle="yes">j</italic> &#x02208; <italic toggle="yes">S<sub>c</sub></italic> and <italic toggle="yes">x</italic> are, respectively, realized values of the outcome Y and <italic toggle="yes">X</italic>; the pseudo-weights <italic toggle="yes">w<sub>j</sub></italic>(<italic toggle="yes">x</italic>) for <italic toggle="yes">j</italic> &#x02208; <italic toggle="yes">S<sub>c</sub></italic> is constructed to balance the distribution in covariates between the target sample and the reference survey. Note X can be a single covariate or a vector of covariates from <italic toggle="yes">X</italic><sub>1</sub>-<italic toggle="yes">X</italic><sub>3</sub>, and are available in both the target sample and the reference survey, while the outcome variable <italic toggle="yes">Y</italic> is available in the target sample <italic toggle="yes">S<sub>c</sub></italic> only.</p><p id="P19">Various PS-based adjustment methods, including PS weighting and PS matching methods, have been developed under the following assumptions. First, the reference survey sample (in our real data example, the NHIS), through weighting, properly represents the target population of interest. Second, all finite population units have a positive participation rate (i.e., each individual in the population has a positive propensity to volunteer to participate in RANDS panel). Third, conditional exchangeability holds with no unmeasured confounders, that is, the probability for each individual in the FP to participate in the target sample is not related to his/her outcome, after adjusting for all measured variables. It is a common practice that the variables in the target sample are measured using same question wordings as in the reference survey to avoid potential reporting or measurement error.</p><p id="P20">While PS weighting and PS matching methods have similar assumptions, PS <italic toggle="yes">weighting</italic> methods construct the pseudo-weight by the inverse of the inclusion probability conditional on <italic toggle="yes">x</italic>, i.e., <inline-formula><mml:math id="M12" display="inline"><mml:mrow><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mfrac><mml:mn>1</mml:mn><mml:mrow><mml:mi>e</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac></mml:mrow></mml:math></inline-formula> for <italic toggle="yes">j</italic> &#x02208; <italic toggle="yes">S<sub>c</sub></italic>, with <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic>) = <italic toggle="yes">p</italic>(<italic toggle="yes">A</italic> = 1&#x02223;<italic toggle="yes">x</italic>), the target sample inclusion probability conditional on <italic toggle="yes">x</italic>. It can also be verified that <italic toggle="yes">A</italic> &#x022a5; <italic toggle="yes">x</italic>&#x02223;<italic toggle="yes">e</italic>(<italic toggle="yes">x</italic>). In contrast, PS <italic toggle="yes">matching</italic> methods distribute the survey sample weights to target sample units that have similar predicted propensity scores. For example, the KW method (<xref rid="R39" ref-type="bibr">Wang et al. 2021</xref>) first assigns the sample weight of each survey unit, say unit <italic toggle="yes">i</italic>, to cohort members proportionally according to kernel distances, defined by propensity scores <inline-formula><mml:math id="M13" display="inline"><mml:mrow><mml:mi>K</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mfrac><mml:mrow><mml:mi>e</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mi>i</mml:mi></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:mo>&#x02212;</mml:mo><mml:mi>e</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mi>h</mml:mi></mml:mfrac><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula> for <italic toggle="yes">j</italic> &#x02208; <italic toggle="yes">S<sub>c</sub></italic>, where <italic toggle="yes">K</italic>(.) a kernel function such as the standard normal density function, and <italic toggle="yes">h</italic> is the bandwidth selected by Silverman&#x02019;s rule of thumb method (<xref rid="R35" ref-type="bibr">Silverman, 1986</xref>). As such, most of the sample weight for survey unit <italic toggle="yes">i</italic> is assigned to those cohort members with similar propensity scores. The assigned portions from survey members to cohort member <italic toggle="yes">j</italic> are then summed up to form the pseudo-weight <italic toggle="yes">w<sub>j</sub></italic>.</p><p id="P21">In <xref rid="S3" ref-type="sec">sections 2.1</xref>-<xref rid="S4" ref-type="sec">2.2</xref>, we assume that <italic toggle="yes">X</italic><sub>1</sub>, <italic toggle="yes">X</italic><sub>2</sub>, and <italic toggle="yes">X</italic><sub>3</sub> are mutually independent in the FP and study how the PS-based adjustment methods reduce the bias and variance through the incorporation of different types of variables in the propensity models. We further consider real situations in <xref rid="S5" ref-type="sec">section 2.3</xref> when different types of variables are correlated in the FP using DAG. Although DAG is a graphical tool developed for causal interpretation, we used it to rule out possible confounding and identify conditioning covariate set for <italic toggle="yes">Y</italic> &#x022a5; <italic toggle="yes">A</italic>. The actual causation is not important in this context. <xref rid="S6" ref-type="sec">Section 2.4</xref> summarizes some practical guidelines for identifying the variable types in real data and choosing between PS-based methods to construct pseudo-weights when covariates interactively affect the target sample participation and the outcome.</p><sec id="S3"><label>2.1</label><title>Bias of <inline-formula><mml:math id="M14" display="inline"><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula> by various types of covariates</title><p id="P22">It is readily shown in <xref rid="F1" ref-type="fig">Figure 1a</xref> that the confounders <italic toggle="yes">X</italic><sub>1</sub> induce the bias when we use the simple sample mean to estimate the population mean <italic toggle="yes">p</italic>(<italic toggle="yes">Y</italic> = 1). Intuitively, the information can be exchanged between the two nodes of A and Y through <italic toggle="yes">X</italic><sub>1</sub>, but not <italic toggle="yes">X</italic><sub>2</sub> or <italic toggle="yes">X</italic><sub>3</sub>. This result is consistent with the bias calculation below. For selection variables (<italic toggle="yes">X</italic> = <italic toggle="yes">X</italic><sub>3</sub>) or predictors (<italic toggle="yes">X</italic> = <italic toggle="yes">X</italic><sub>2</sub>), we have <inline-formula><mml:math id="M15" display="inline"><mml:mrow><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:msub><mml:mo>&#x02211;</mml:mo><mml:mi>x</mml:mi></mml:msub><mml:mo stretchy="false">[</mml:mo><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>Y</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo stretchy="false">&#x02223;</mml:mo><mml:mi>X</mml:mi><mml:mo>=</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>A</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo stretchy="false">&#x02223;</mml:mo><mml:mi>X</mml:mi><mml:mo>=</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>X</mml:mi><mml:mo>=</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mo stretchy="false">]</mml:mo></mml:mrow><mml:mrow><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>Y</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo stretchy="false">)</mml:mo><mml:msub><mml:mo>&#x02211;</mml:mo><mml:mi>x</mml:mi></mml:msub><mml:mo stretchy="false">[</mml:mo><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>A</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo stretchy="false">&#x02223;</mml:mo><mml:mi>X</mml:mi><mml:mo>=</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>X</mml:mi><mml:mo>=</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mo stretchy="false">]</mml:mo></mml:mrow></mml:mfrac><mml:mo>=</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:math></inline-formula> and hence <italic toggle="yes">Bias</italic> = 0. For confounders, however, <italic toggle="yes">Bias</italic> &#x02260; 0 To correct for the bias induced by <italic toggle="yes">X</italic><sub>1</sub>, PS-based adjustment methods create pseudo-weights and reweight the target sample such that the weighted sample distribution of the confounder <italic toggle="yes">X</italic><sub>1</sub> is same as that in the FP, i.e., <italic toggle="yes">X</italic><sub>1</sub> &#x022a5; <italic toggle="yes">A</italic> as shown in <xref rid="F1" ref-type="fig">Figure 1b</xref>. The dotted line denotes the path <italic toggle="yes">X</italic><sub>1</sub>-A is blocked (i.e., there is no information exchange between the two nodes) by reweighting the target sample and hence <italic toggle="yes">A</italic> &#x022a5; <italic toggle="yes">Y</italic>.</p><p id="P23">As a result, the estimator <inline-formula><mml:math id="M16" display="inline"><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula> with the set of pseudo-weights <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>), where <italic toggle="yes">x</italic><sub>1</sub> is the realized value of the confounder <italic toggle="yes">X</italic><sub>1</sub>, is approximately unbiased. Analogously, it is readily shown that the estimator <inline-formula><mml:math id="M17" display="inline"><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover></mml:math></inline-formula> with pseudo-weights defined by the inverse of sample inclusion probabilities that balance the <italic toggle="yes">x</italic><sub>1</sub> distribution between the target sample and the FP, including <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>), <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>), or <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>3</sub>), is also unbiased. Note that the three sets of pseudo-weights of <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>), <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>), or <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>3</sub>) balance the <italic toggle="yes">x</italic><sub>1</sub> distribution and also the distribution of <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>3</sub>, or <italic toggle="yes">x</italic><sub>2</sub> and <italic toggle="yes">x</italic><sub>3</sub>, respectively, between the target sample <italic toggle="yes">S<sub>c</sub></italic> and the FP (<xref rid="R34" ref-type="bibr">Rosenbaum and Rubin, 1983</xref>).</p><p id="P24">In contrast, pseudo-weights of <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>2</sub>), <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>3</sub>) or <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>3</sub>) do not balance the <italic toggle="yes">X</italic><sub>1</sub> distribution and therefore the corresponding weighted estimators in <xref rid="FD1" ref-type="disp-formula">(1)</xref> are biased.</p></sec><sec id="S4"><label>2.2</label><title>Variance of <inline-formula><mml:math id="M18" display="inline"><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula> by various types of covariates</title><p id="P25">Among the four unbiased estimators based on <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic><sub>1</sub>), <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>), <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>), and <italic toggle="yes">e</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>3</sub>), we compare their efficiencies. We first compare the variance of <inline-formula><mml:math id="M19" display="inline"><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula> with <italic toggle="yes">x</italic> the realized value of <italic toggle="yes">X</italic> = <italic toggle="yes">X</italic><sub>1</sub> versus <italic toggle="yes">X</italic> = (<italic toggle="yes">X</italic><sub>1</sub>, <italic toggle="yes">X</italic><sub>3</sub>), denoted by <inline-formula><mml:math id="M20" display="inline"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula> and <inline-formula><mml:math id="M21" display="inline"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula>, respectively. We write
<disp-formula id="FD2">
<mml:math id="M2" display="block"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mfrac><mml:mn>1</mml:mn><mml:mrow><mml:msub><mml:mo>&#x02211;</mml:mo><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:msub><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac><mml:mo>&#x02211;</mml:mo><mml:mtable><mml:mtr><mml:mtd columnalign="left"><mml:mrow/></mml:mtd></mml:mtr><mml:mtr><mml:mtd columnalign="left"><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:mtd></mml:mtr></mml:mtable><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:msub><mml:mi>y</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>,</mml:mo><mml:mtext>and</mml:mtext></mml:mrow></mml:math>
</disp-formula>
<disp-formula id="FD3">
<mml:math id="M3" display="block"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mfrac><mml:mn>1</mml:mn><mml:mrow><mml:msub><mml:mo>&#x02211;</mml:mo><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:msub><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac><mml:mo>&#x02211;</mml:mo><mml:mtable><mml:mtr><mml:mtd columnalign="left"><mml:mrow/></mml:mtd></mml:mtr><mml:mtr><mml:mtd columnalign="left"><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:mtd></mml:mtr></mml:mtable><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:msub><mml:mi>y</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:math>
</disp-formula></p><p id="P26">Note the selection variable is independent of the outcome and thus the pseudo-weights based on <italic toggle="yes">x</italic><sub>3</sub> are non-informative of the outcome Y. The corresponding pseudo-weighted mean, although adding no bias, loses efficiency due to the differential non-informative pseudo-weights. Taking the adjusted logistic propensity pseudo-weights (denoted by ALP in <xref rid="R39" ref-type="bibr">Wang et al. 2021</xref>) as an example, under the logistic regression propensity model
<disp-formula id="FD4">
<label>(2)</label>
<mml:math id="M4" display="block"><mml:mrow><mml:mi>log</mml:mi><mml:mfrac><mml:mrow><mml:msub><mml:mi>p</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mo>&#x02212;</mml:mo><mml:msub><mml:mi>p</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow></mml:mfrac><mml:mo>=</mml:mo><mml:mi>log</mml:mi><mml:mspace width="thinmathspace"/><mml:msub><mml:mi>&#x003c0;</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:msubsup><mml:mi>&#x003b2;</mml:mi><mml:mi>x</mml:mi><mml:mi>T</mml:mi></mml:msubsup><mml:msub><mml:mi>x</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>,</mml:mo></mml:mrow></mml:math>
</disp-formula>
where <inline-formula><mml:math id="M22" display="inline"><mml:mrow><mml:msub><mml:mi>p</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mi>p</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msubsup><mml:mi>S</mml:mi><mml:mi>c</mml:mi><mml:mo>&#x02217;</mml:mo></mml:msubsup><mml:mo stretchy="false">&#x02223;</mml:mo><mml:mi>F</mml:mi><mml:msup><mml:mi>P</mml:mi><mml:mo>&#x02217;</mml:mo></mml:msup><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula> and <inline-formula><mml:math id="M23" display="inline"><mml:mrow><mml:mi>F</mml:mi><mml:msup><mml:mi>P</mml:mi><mml:mo>&#x02217;</mml:mo></mml:msup><mml:mo>=</mml:mo><mml:msubsup><mml:mi>S</mml:mi><mml:mi>c</mml:mi><mml:mo>&#x02217;</mml:mo></mml:msubsup><mml:mo>&#x0222a;</mml:mo><mml:mi>F</mml:mi><mml:mi>P</mml:mi></mml:mrow></mml:math></inline-formula> denotes the pseudopopulation by combining <inline-formula><mml:math id="M24" display="inline"><mml:mrow><mml:msubsup><mml:mi>S</mml:mi><mml:mi>c</mml:mi><mml:mo>&#x02217;</mml:mo></mml:msubsup></mml:mrow></mml:math></inline-formula> (i.e., a copy of the target sample <italic toggle="yes">S<sub>c</sub></italic>) and the FP, and <italic toggle="yes">&#x003b2;</italic><sub><italic toggle="yes">x</italic></sub> is the regression coefficient associated with <italic toggle="yes">x</italic>. The ALP pseudo-weight <italic toggle="yes">w</italic><sub><italic toggle="yes">j</italic></sub>(<italic toggle="yes">x</italic>) is constructed as <inline-formula><mml:math id="M25" display="inline"><mml:mrow><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:mi>x</mml:mi><mml:mo stretchy="false">)</mml:mo><mml:mo>=</mml:mo><mml:msup><mml:mtext>exp</mml:mtext><mml:mrow><mml:mo>&#x02212;</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:msup><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:msubsup><mml:mi>&#x003b2;</mml:mi><mml:mi>x</mml:mi><mml:mi>T</mml:mi></mml:msubsup><mml:msub><mml:mi>x</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula> for <italic toggle="yes">j</italic> &#x02208; <italic toggle="yes">S<sub>c</sub></italic>.</p><p id="P27">For simple illustration, assume <xref rid="FD4" ref-type="disp-formula">model (2)</xref> includes main effects of covariates, so <italic toggle="yes">w<sub>j</sub></italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>) = <italic toggle="yes">w<sub>j</sub></italic>(<italic toggle="yes">x</italic><sub>1</sub>)<italic toggle="yes">w<sub>j</sub></italic>(<italic toggle="yes">x</italic><sub>3</sub>) and <italic toggle="yes">w<sub>j</sub></italic>(<italic toggle="yes">x</italic><sub>3</sub>) are noninformative weights since <italic toggle="yes">x</italic><sub>3</sub> &#x022a5; <italic toggle="yes">y</italic>. Under the assumption that the variance of the observations is approximately constant (<xref rid="R17" ref-type="bibr">Kish, 1992</xref>), the proportional increase in variance from weighting, denoted by L, is approximated to be
<disp-formula id="FD5">
<mml:math id="M5" display="block"><mml:mrow><mml:mi>L</mml:mi><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo stretchy="true">^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo stretchy="true">^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:mfrac><mml:mo>&#x02212;</mml:mo><mml:mn>1</mml:mn><mml:mo>=</mml:mo><mml:mi>C</mml:mi><mml:msup><mml:mi>V</mml:mi><mml:mn>2</mml:mn></mml:msup><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>&#x0003e;</mml:mo><mml:mn>0</mml:mn><mml:mo>,</mml:mo></mml:mrow></mml:math>
</disp-formula>
where CV is the coefficient of variation of the <italic toggle="yes">w<sub>j</sub></italic>(<italic toggle="yes">x</italic><sub>3</sub>) weights. Thus, <inline-formula><mml:math id="M26" display="inline"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>&#x0003e;</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula>.</p><p id="P28">Note that the model parameter <italic toggle="yes">&#x003b2;<sub>x</sub></italic> = 0 in (<xref rid="FD4" ref-type="disp-formula">2</xref>) if <italic toggle="yes">x</italic> is an outcome predictor, which does not predict the target sample membership A, such as <italic toggle="yes">x</italic><sub>2</sub> in <xref rid="F1" ref-type="fig">Figure 1a</xref>. As a result, <inline-formula><mml:math id="M27" display="inline"><mml:mrow><mml:mi>w</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:mo>=</mml:mo><mml:msup><mml:mtext>exp</mml:mtext><mml:mrow><mml:mo>&#x02212;</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:msup><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:msubsup><mml:mi>&#x003b2;</mml:mi><mml:mrow><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub></mml:mrow><mml:mi>T</mml:mi></mml:msubsup><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>+</mml:mo><mml:mn>0</mml:mn></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mi>w</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula> and thus
<disp-formula id="FD6">
<mml:math id="M6" display="block"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:mo>=</mml:mo><mml:mfrac><mml:mn>1</mml:mn><mml:mrow><mml:msub><mml:mo>&#x02211;</mml:mo><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:msub><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac><mml:mo>&#x02211;</mml:mo><mml:mtable><mml:mtr><mml:mtd columnalign="left"><mml:mrow/></mml:mtd></mml:mtr><mml:mtr><mml:mtd columnalign="left"><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:mtd></mml:mtr></mml:mtable><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:msub><mml:mi>y</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:mo>=</mml:mo><mml:mfrac><mml:mn>1</mml:mn><mml:mrow><mml:msub><mml:mo>&#x02211;</mml:mo><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:msub><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac><mml:mo>&#x02211;</mml:mo><mml:mtable><mml:mtr><mml:mtd columnalign="left"><mml:mrow/></mml:mtd></mml:mtr><mml:mtr><mml:mtd columnalign="left"><mml:mrow><mml:mi>j</mml:mi><mml:mo>&#x02208;</mml:mo><mml:msub><mml:mi>S</mml:mi><mml:mi>c</mml:mi></mml:msub></mml:mrow></mml:mtd></mml:mtr></mml:mtable><mml:msub><mml:mi>w</mml:mi><mml:mi>j</mml:mi></mml:msub><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo><mml:msub><mml:mi>y</mml:mi><mml:mi>j</mml:mi></mml:msub></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>.</mml:mo></mml:mrow></mml:math>
</disp-formula></p><p id="P29">Along the same line of justification, <inline-formula><mml:math id="M28" display="inline"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow></mml:mrow></mml:math></inline-formula>. In conclusion,
<disp-formula id="FD7">
<mml:math id="M7" display="block"><mml:mrow><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>&#x0003c;</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>=</mml:mo><mml:mi>V</mml:mi><mml:mrow><mml:mo stretchy="true">(</mml:mo><mml:mrow><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>1</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mo>,</mml:mo><mml:msub><mml:mi>x</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mo stretchy="true">)</mml:mo></mml:mrow><mml:mo>.</mml:mo></mml:mrow></mml:math>
</disp-formula></p><p id="P30">In summary, to achieve unbiasedness and efficiency of pseudo-weighted mean estimators, the propensity model that considers confounders (<italic toggle="yes">X</italic><sub>1</sub>) alone, or together with outcome predictors (<italic toggle="yes">X</italic><sub>2</sub>), should be used to construct the pseudo-weights in <xref rid="FD1" ref-type="disp-formula">eq(1)</xref>. The resulting mean estimates are unbiased and most efficient. The inclusion of selection variables in the propensity model, in addition to all confounders, adds no more bias, however, will inflate the variances of the estimates. In contrast, the inclusion of outcome predictors does not inflate the variance while retaining the unbiasedness of the FP mean estimates. A short version of the recommendation for PS-based pseudo-weights construction: include all confounders but avoid selection variables in the propensity model.</p><p id="P31">The above justification assumes the logistic regression <xref rid="FD4" ref-type="disp-formula">model (2)</xref> with main effects is true. More rigorous justification is needed when different types of covariates are correlated; propensity models are mis-specified (that is, the logistic regression <xref rid="FD4" ref-type="disp-formula">model (2)</xref> is not the true model); and the pseudo-weights (i.e., propensity model coefficients) are unknown and have to be estimated.</p></sec><sec id="S5"><label>2.3</label><title>Correlation between covariates</title><p id="P32">We now consider more realistic scenarios in which the confounders, the outcome predictors, and the selection variables can be correlated to each other. <xref rid="F2" ref-type="fig">Figure 2</xref> shows cases where correlation exists between the pairs <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub>, <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub>, and <italic toggle="yes">X</italic><sub>2</sub> and <italic toggle="yes">X</italic><sub>3</sub>, respectively. In addition, any two or all three pairs can be correlated simultaneously in the FP.</p><p id="P33">For unbiased estimation of the FP mean of Y using the target sample (A=1), we need to block all paths connecting A and Y such that <italic toggle="yes">Y</italic> &#x022a5; <italic toggle="yes">A</italic>. We focus on paths that point to A since in the propensity model we construct weights for the target sample units (with A=1) so that the weighted target sample and the FP have same distributions in certain covariates X, i.e. A&#x022a5;X&#x02223;e(X).</p><p id="P34">As shown by the dotted lines in <xref rid="F2" ref-type="fig">Figure 2</xref>, two paths in <xref rid="F2" ref-type="fig">Figure 2a</xref> and <xref rid="F2" ref-type="fig">2c</xref>, and one path in <xref rid="F2" ref-type="fig">Figure 2b</xref> are identified and need to be blocked, i.e., prevent information flow between A and Y, in order to achieve <italic toggle="yes">Y</italic> &#x022a5; <italic toggle="yes">A</italic>. The backdoor criteria (<xref rid="R31" ref-type="bibr">Pearl, 2009</xref>) is a way to rule out confounding via conditioning, and allows identifying the causal effect from A to Y (equal to zero in <xref rid="F2" ref-type="fig">Figure 2</xref>, i.e., <italic toggle="yes">Y</italic> &#x022a5; <italic toggle="yes">A</italic>) after conditioning a set of covariates that block the backdoor paths between A and Y. Here the identified paths in <xref rid="F2" ref-type="fig">Figure 2</xref> are backdoor paths because the arrows point into <italic toggle="yes">A</italic> (not the opposite direction if arrows point from <italic toggle="yes">A</italic> towards <italic toggle="yes">X</italic><sub>1</sub>-<italic toggle="yes">X</italic><sub>3</sub>). By the backdoor criteria, <italic toggle="yes">X</italic><sub>1</sub> blocks the identified paths in <xref rid="F2" ref-type="fig">Figure 2a</xref>-<xref rid="F2" ref-type="fig">b</xref>. As follows, we construct PS-based pseudo-weights <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>) so that the <italic toggle="yes">X</italic><sub>1</sub> distribution in the weighted target sample is same as that in the FP in <xref rid="F2" ref-type="fig">Figure 2a</xref>-<xref rid="F2" ref-type="fig">b</xref> when <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub> or <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub> are correlated (i.e., <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub> &#x02260; 0 or <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub> &#x02260; 0). Thus, the <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>)-weighted target sample mean of Y is an unbiased estimator of the FP mean. In <xref rid="F2" ref-type="fig">Figure 2c</xref>, <italic toggle="yes">X</italic><sub>2</sub> or <italic toggle="yes">X</italic><sub>3</sub>, in addition to <italic toggle="yes">X</italic><sub>1</sub>, block the two identified paths (<xref rid="R31" ref-type="bibr">Pearl, 2009</xref>). Following the same logic, pseudo-weights that balance the distributions in <italic toggle="yes">X</italic><sub>2</sub> or <italic toggle="yes">X</italic><sub>3</sub>, in addition to <italic toggle="yes">X</italic><sub>1</sub>, denoted by <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>) or <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>), should be constructed for the target sample units when the pair of <italic toggle="yes">X</italic><sub>2</sub> and <italic toggle="yes">X</italic><sub>3</sub> are correlated in <xref rid="F2" ref-type="fig">Figure 2c</xref> (<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub> &#x02260; 0). This result also applies to cases when any two pairs or all three pairs of covariates are simultaneously correlated in the FP, and the <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>)- or <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>)-pseudo-weighted target sample means are approximately unbiased.</p><p id="P35">In summary, similar to the scenario shown in <xref rid="F2" ref-type="fig">Figure 2</xref>, in order to block the dotted paths when covariates interactively affect the outcome, PS-based adjustment methods can be applied to construct pseudo-weights that balance the distributions of <italic toggle="yes">X</italic><sub>1</sub> (<xref rid="F2" ref-type="fig">Figure 2a</xref>-<xref rid="F2" ref-type="fig">b</xref>) and (<italic toggle="yes">X</italic><sub>1</sub>, <italic toggle="yes">X</italic><sub>2</sub>) or (<italic toggle="yes">X</italic><sub>1</sub>, <italic toggle="yes">X</italic><sub>3</sub>) (<xref rid="F2" ref-type="fig">Figure 2c</xref>) in the pseudo-weighted sample and the FP.</p></sec><sec id="S6"><label>2.4</label><title>Practical guidelines</title><p id="P36">In practice, the variable types (confounder, predictor, selection variable) need to be identified for propensity model construction. Since we are not concerned about model interpretation, parametric models with complex functional forms or nonparametric models can be fitted. In our RANDS example (<xref rid="S11" ref-type="sec">Section 4</xref>), both the outcome and propensity models were selected by automatic backward selection methods. Starting from the full model containing all factors and their pairwise interaction terms, we removed the interaction term with the largest p-value and re-fit the model. We continued the iterations until all p-values of the interaction terms were less than 0.05. For each interaction, complex survey designs were accounted for in the logistic regression analysis using the svyglm() function in the R survey package (<xref rid="R25" ref-type="bibr">Lumley, 2020</xref>). The main effects with p-values greater than 0.05 were removed only if they were not involved in any of significant interaction terms. As results, each type of variables is identified: confounders are common terms in both the selected propensity and the outcome models; the selection variables (or predictors) are those selected in the propensity (or outcome) model only. Note that each type of variables may contain multiple variables as well as their nonlinear or nonadditive functions (e.g., pairwise interactions) in the final outcome and the propensity models.</p><p id="P37">Alternative model selection criteria can be employed, such as Akaike Information Criterion (AIC) or Bayesian Information Criterion (BIC) (<xref rid="R24" ref-type="bibr">Lumley and Scott, 2015</xref>) to identify variable types. <xref rid="R41" ref-type="bibr">Yang et al. (2020)</xref> and <xref rid="R7" ref-type="bibr">Chen, Valliant, and Elliott (2018)</xref> have also proposed variable selection methods, including penalized estimating equations or LASSO regression, which can be used to identify variable types for inclusion in the PS model. In the case where the outcome of interest is not available in the reference probability sample or the outcome has not yet been collected in the target sample, subject matter literature and knowledge may have to be used to assign the covariate types. Variable type identification is critical in practice and comparing different model selection methods to create the final models is of future research interest.</p><p id="P38">The true propensity model of the underlying selection mechanism of the target sample (A=1) is often unknown but complicated, which may involve covariate terms of higher orders of nonlinearity and/or nonadditivity. For example, <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub> (or <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub>) can interactively affect the outcome Y (or selection indicator A), the scenario considered in simulation study 3 (to be shown in <xref rid="S7" ref-type="sec">section 3</xref>). In order to estimate the propensity scores accurately to achieve the covariate balance so that the condition of <italic toggle="yes">Y</italic> &#x022a5; <italic toggle="yes">A</italic> holds, data analysts need to be careful in choosing the PS-based adjustment methods among PS weighting or matching methods based on parametric models such as logistic regression and nonparametric methods such as machine learning.</p><p id="P39">For example, PS weighting methods (such as the ALP) can be sensitive to model misspecification (<xref rid="R37" ref-type="bibr">Wang et al., 2020a</xref>). ALP-weighted target sample distributions match the FP distributions when the assumed propensity model is true. For instance, ALP pseudo-weights that are constructed based on the propensity model of A on <italic toggle="yes">X</italic><sub>1</sub>, <italic toggle="yes">X</italic><sub>3</sub>, and their interaction <italic toggle="yes">X</italic><sub>1</sub> * <italic toggle="yes">X</italic><sub>3</sub>, produce unbiased estimators. The estimators, however, are biased if the model is misspecified, for example, the interaction term is omitted from the propensity model.</p><p id="P40">In contrast, PS <italic toggle="yes">matching</italic> methods construct weights by matching target sample units with reference sample units using the estimated propensity scores, followed by distributing reference sample weights to target sample units with similar propensities. It has been well recognized that PS matching, compared to PS weighting methods, is more robust to model misspecification (<xref rid="R37" ref-type="bibr">Wang et al., 2020a</xref>). In our limited simulation studies, it is shown that the balance in covariate distributions between the KW-weighted sample and the FP can be achieved as long as the blocking variables, that is, <italic toggle="yes">X</italic><sub>1</sub> in <xref rid="F2" ref-type="fig">Figure 2a</xref>-<xref rid="F2" ref-type="fig">b</xref>; <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub> or <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub> in <xref rid="F2" ref-type="fig">Figure 2c</xref>, are included (with or without <italic toggle="yes">X</italic><sub>1</sub> * <italic toggle="yes">X</italic><sub>3</sub> interaction) in the propensity model (as shown in <xref rid="F3" ref-type="fig">Figure 3</xref>). For complicated propensity models with higher orders of interactions and/or nonlinearity, including only the main effects of the blocking variables in the propensity model by KW methods might not be sufficient. Nonparametric modeling such as machine learning methods may be promising (<xref rid="R16" ref-type="bibr">Kern et al., 2020</xref>) in identifying nonlinear or nonadditive relationships of covariates with the target sample selection.</p></sec></sec><sec id="S7"><label>3.</label><title>Simulation</title><p id="P41">Simulation studies were conducted to evaluate the performance of the mean estimator from <xref rid="FD1" ref-type="disp-formula">(1)</xref> with the pseudo-weights constructed by the ALP and the KW methods based on propensity models that consider different types of covariates.</p><sec id="S8"><title>Population Generation</title><p id="P42">We generate a finite population <italic toggle="yes">FP</italic> = {<italic toggle="yes">X</italic><sub>1<italic toggle="yes">i</italic></sub>, <italic toggle="yes">X</italic><sub>2<italic toggle="yes">i</italic></sub>, <italic toggle="yes">X</italic><sub>3<italic toggle="yes">i</italic></sub>, <italic toggle="yes">Y<sub>i</sub></italic> for <italic toggle="yes">i</italic> = 1, &#x02026; <italic toggle="yes">N</italic>} with population size <italic toggle="yes">N</italic> = 20,000. Three covariates <italic toggle="yes">X</italic><sub>1</sub>, <italic toggle="yes">X</italic><sub>2</sub>, and <italic toggle="yes">X</italic><sub>3</sub> follow standard trivariate normal distributions with pairwise correlations <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>. A binary outcome Y is generated following the Bernoulli distribution with a mean of
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</disp-formula></p><p id="P43">We specify (<italic toggle="yes">&#x003b1;</italic><sub>0</sub>, <italic toggle="yes">&#x003b1;</italic><sub>1</sub>, <italic toggle="yes">&#x003b1;</italic><sub>2</sub>) = (&#x02212;1, .5, .5) so that <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>2</sub> are associated with <italic toggle="yes">Y</italic> as in <xref rid="F1" ref-type="fig">Figure 1</xref>, but vary <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = 0.5 or 0 with and without the interaction term. As a result, the FP mean <inline-formula><mml:math id="M29" display="inline"><mml:mrow><mml:mover accent="true"><mml:mi>Y</mml:mi><mml:mo>&#x000af;</mml:mo></mml:mover><mml:mo>&#x02248;</mml:mo><mml:mn>0.29</mml:mn></mml:mrow></mml:math></inline-formula>.</p></sec><sec id="S9"><title>Selection of the target sample (with A=1)</title><p id="P44">A sample of size <italic toggle="yes">n<sub>c</sub></italic> = 1,000, denoted by <italic toggle="yes">S<sub>c</sub></italic>, is selected from the FP, using the design of probability proportional to size (PPS) sampling with measure of size (<italic toggle="yes">mos</italic>): <italic toggle="yes">mos</italic> = exp(<italic toggle="yes">&#x003b2;</italic><sub>0</sub> + <italic toggle="yes">&#x003b2;</italic><sub>1</sub><italic toggle="yes">X</italic><sub>1</sub> + <italic toggle="yes">&#x003b2;</italic><sub>3</sub><italic toggle="yes">X</italic><sub>3</sub> + <italic toggle="yes">&#x003b2;</italic><sub>13</sub><italic toggle="yes">X</italic><sub>1</sub><italic toggle="yes">X</italic><sub>3</sub>) so that the inclusion probability is
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</disp-formula></p><p id="P45">We specify <italic toggle="yes">&#x003b2;</italic> = (<italic toggle="yes">&#x003b2;</italic><sub>0</sub>, <italic toggle="yes">&#x003b2;</italic><sub>1</sub>, <italic toggle="yes">&#x003b2;</italic><sub>3</sub>) = (&#x02212;1, .5, .5) so that <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>3</sub> are associated with <italic toggle="yes">A</italic> as in <xref rid="F1" ref-type="fig">Figure 1</xref>. In addition, we vary <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = .5 or 0 with or without the interactive effect in the propensity model. We have the target sample participation rate of <italic toggle="yes">E</italic>(<italic toggle="yes">A</italic>) = .05.</p><p id="P46">The inclusion probabilities (i.e., sample weights) are masked in the analysis and treated as unknown (i.e., equal sample weights of 1 used). Note that the target sample without weights is not representative of the population.</p></sec><sec id="S10"><title>Selection of a probability sample</title><p id="P47">An independent probability sample of size <italic toggle="yes">n<sub>s</sub></italic> = 500, denoted by <italic toggle="yes">S<sub>s</sub></italic>, is selected using the same sampling design as the target sample selection. The selected probability sample has known selection probabilities. The weighted probability sample is used as the reference survey, representing the underlying FP in the propensity analysis.</p><p id="P48">Pseudo-weighted means, i.e., (<xref rid="FD1" ref-type="disp-formula">1</xref>), with estimated pseudo-weights constructed under different propensity models, including the confounders (<italic toggle="yes">X</italic><sub>1</sub>), outcome predictors (<italic toggle="yes">X</italic><sub>2</sub>), the selection variables (<italic toggle="yes">X</italic><sub>3</sub>), and/or their interactions, were compared. Three simulation studies are conducted with results presented in <xref rid="T1" ref-type="table">Tables 1</xref>-<xref rid="T2" ref-type="table">2</xref> and <xref rid="F3" ref-type="fig">Figure 3</xref>. Simulation 1 considers a simple scenario of independent covariates in the FP (with <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub> = <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub> = <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub> = 0) without interaction effects of covariates on the outcome or the target sample inclusion (i.e., <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = 0). Simulation 2 varies the covariate correlation in the FP by (<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (.6,0,0), (0,.6,0), (0,0,.6), (.6,.6,0), (.6,0,.6), (0,.6,.6), or (.6,.6,.6) , while keeping <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = 0. Simulation 3 further complicates the underlying outcome model and the propensity model by including the interaction terms with <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = 0.5.</p><p id="P49"><xref rid="T1" ref-type="table">Tables 1</xref>-<xref rid="T2" ref-type="table">2</xref> show the bias, empirical variance (EmpVar), and MSE of the KW estimate, over B=500 iterations, from simulations 1-2, respectively, and
<disp-formula id="FD10">
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where <inline-formula><mml:math id="M30" display="inline"><mml:mrow><mml:msup><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mrow><mml:mo stretchy="false">(</mml:mo><mml:mi>b</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math></inline-formula> is the KW estimate of the population mean using the b<sup>th</sup> simulated target sample under various analytical propensity models. The w(<italic toggle="yes">x</italic><sub>1</sub>), w(<italic toggle="yes">x</italic><sub>12</sub>), and w(<italic toggle="yes">x</italic><sub>13</sub>) denote the propensity models including main effects of, respectively, <italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>3</sub>. Models including <italic toggle="yes">x</italic><sub>2</sub> only, <italic toggle="yes">x</italic><sub>3</sub> only, and <italic toggle="yes">x</italic><sub>2</sub> and <italic toggle="yes">x</italic><sub>3</sub> are denoted as w(<italic toggle="yes">x</italic><sub>2</sub>), w(<italic toggle="yes">x</italic><sub>3</sub>), and w(<italic toggle="yes">x</italic><sub>23</sub>), respectively.</p><p id="P50">Three observations are made in <xref rid="T1" ref-type="table">Table 1</xref>. <italic toggle="yes">Firstly</italic>, consistent with our expectations, all propensity models that include the confounder <italic toggle="yes">x</italic><sub>1</sub>, i.e. w(<italic toggle="yes">x</italic><sub>1</sub>), w(<italic toggle="yes">x</italic><sub>12</sub>), w(<italic toggle="yes">x</italic><sub>13</sub>), produce approximately unbiased estimates of the FP mean of Y; the estimates are badly biased under the propensity models which include <italic toggle="yes">x</italic><sub>2</sub> only, <italic toggle="yes">x</italic><sub>3</sub> only, or <italic toggle="yes">x</italic><sub>2</sub> and <italic toggle="yes">x</italic><sub>3</sub>. <italic toggle="yes">Secondly</italic>, the propensity model w(<italic toggle="yes">x</italic><sub>3</sub>) yields inflated variance estimates compared to w(<italic toggle="yes">x</italic><sub>1</sub>) or w(<italic toggle="yes">x</italic><sub>2</sub>), and w(<italic toggle="yes">x</italic><sub>2</sub>) has the smallest empirical variances. <italic toggle="yes">Thirdly</italic>, among the three approximately unbiased estimators, w(<italic toggle="yes">x</italic><sub>1</sub>) yields the most efficient estimates relative to w(<italic toggle="yes">x</italic><sub>12</sub>) or w(<italic toggle="yes">x</italic><sub>13</sub>).</p><p id="P51"><xref rid="T2" ref-type="table">Table 2</xref> presents results from simulation 2 with varying covariate correlations. Three observations are made. <italic toggle="yes">Firstly</italic>, pseudo-weights that balance the distributions in <italic toggle="yes">x</italic><sub>2</sub> or <italic toggle="yes">x</italic><sub>3</sub>, in addition to <italic toggle="yes">x</italic><sub>1</sub>, produced approximately unbiased estimates across various correlations; see the shaded two columns of w(<italic toggle="yes">x</italic><sub>12</sub>) and w(<italic toggle="yes">x</italic><sub>13</sub>). <italic toggle="yes">Secondly</italic>, among the two, w(<italic toggle="yes">x</italic><sub>12</sub>) and w(<italic toggle="yes">x</italic><sub>13</sub>), the empirical variance estimates and MSEs under w(<italic toggle="yes">x</italic><sub>12</sub>) tend to be smaller than those under w(<italic toggle="yes">x</italic><sub>13</sub>). <italic toggle="yes">Thirdly</italic>, the inclusion of only the confounder <italic toggle="yes">x</italic><sub>1</sub> in the propensity model, i.e., <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>), although efficient, may induce bias, especially when correlation exists between <italic toggle="yes">x</italic><sub>2</sub> and <italic toggle="yes">x</italic><sub>3</sub>.</p><p id="P52">Simulation 3 compares biases of estimated population means by the KW matching method and the ALP weighting method when the underlying outcome and propensity models include the interaction terms, i.e., <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = 0.5 (see <xref rid="F3" ref-type="fig">Figure 3</xref>). Four analytic propensity models, including <italic toggle="yes">X</italic><sub>2</sub> or <italic toggle="yes">X</italic><sub>3</sub> in addition to the confounder <italic toggle="yes">x</italic><sub>1</sub>, are considered and they are 1) w(<italic toggle="yes">x</italic><sub>12</sub>), <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub> main effects only, 2) w(<italic toggle="yes">x</italic><sub>13</sub>), <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub> main effects only, 3) w(<italic toggle="yes">x</italic><sub>1</sub> * <italic toggle="yes">x</italic><sub>2</sub>), <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub> main effects and their interaction, and 4) w(<italic toggle="yes">x</italic><sub>1</sub> * <italic toggle="yes">x</italic><sub>3</sub>), including <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub> main effects and their interaction. Recall KW is a type of PS matching method and expected to be more robust to model misspecification compared to the ALP method. As expected, the KW method consistently yields approximately unbiased estimates across four propensity models with or without interaction terms. In the contrast, the ALP approach directly uses the inverse of the participation rates estimated from the assumed propensity model as pseudo-weights, and the ALP estimates are approximately unbiased only under the true propensity model w(<italic toggle="yes">x</italic><sub>1</sub> * <italic toggle="yes">x</italic><sub>3</sub>). Furthermore, it can be observed that biases of the ALP estimates are consistently closer to zero than the KW under the true model. Results with covariate correlations (<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (.6,0,0), (0,0,.6), (.6,0,.6) and (0,.6,.6) showed a similar pattern and hence are not shown.</p></sec></sec><sec id="S11"><label>4.</label><title>Real data analysis</title><p id="P53">RANDS, a series of web-based probability panel surveys conducted at NCHS (<ext-link xlink:href="https://www.cdc.gov/nchs/rands" ext-link-type="uri">https://www.cdc.gov/nchs/rands</ext-link>), has been used for methodological research and, more recently, for providing early experimental estimates on the COVID-19 pandemic. RANDS has the capability to collect data quickly and is less costly than traditional national household surveys, but is subject to potential selection bias due to low response rates. Adjustment methods to construct pseudo-weights, including propensity-score based methods, are applied to balance the covariate distributions in the target sample and the FP, and are an important component of the RANDS program. We consider the simulation findings from this paper for selecting PS-model covariates to estimate the national prevalence of asthma compared to NCHS&#x02019; NHIS.</p><p id="P54">Data from the third round of RANDS (RANDS 3) is evaluated. RANDS 3 was collected in 2019 using NORC&#x02019;s AmeriSpeak&#x000ae; Panel (<ext-link xlink:href="https://amerispeak.norc.org" ext-link-type="uri">https://amerispeak.norc.org</ext-link>) and included responses from 2,646 panelists aged 18 years and older. RANDS 3 panelists were surveyed via web and were asked questions related to general and mental health, medical conditions, opioid use, and pain. The RANDS 3 cumulative response rate was 18.1%. The RANDS 3 original panel weights were developed by the inverse of the probability of inclusion in the AmeriSpeak&#x000ae; Panel, subject to nonresponse adjustment and poststratification adjustment to external population totals of age, sex, education, race/ethnicity, housing tenure, telephone status, and Census Division (<xref rid="R28" ref-type="bibr">National Center for Health Statistics, 2020</xref>). The original panel-weighted estimate of diagnosed asthma (ever been told you had asthma) in RANDS 3 was 16.86% (standard error = 0.98%). For comparison, the unweighted estimate of diagnosed asthma in RANDS 3 was 16.40% (standard error = 0.72%). The 2019 NHIS (n=31,997) is evaluated as the gold standard. The NHIS (<ext-link xlink:href="https://www.cdc.gov/nchs/nhis" ext-link-type="uri">https://www.cdc.gov/nchs/nhis</ext-link>) is a cross-sectional household interview survey that collects information on a broad range of health topics, primarily through face-to-face interviews. The NHIS sample adult file, which is a collection of responses from one randomly selected adult per selected household, was used to evaluate the prevalence of ever having asthma among adults. The percentage of adults who ever had asthma based on the 2019 NHIS (n=31,997) was 13.46% (standard error = 0.25%).</p><p id="P55">Common covariates available in RANDS 3 and the 2019 NHIS that were potentially related to diagnosed asthma or the selection indicator were considered (see <xref rid="T3" ref-type="table">Table 3</xref>). All percent estimates in <xref rid="T3" ref-type="table">Table 3</xref> (when expressed as proportions) meet the NCHS data presentation standards for proportions (<xref rid="R30" ref-type="bibr">Parker et al., 2017</xref>). As observed, demographic variables of age, sex and race/ethnicity have similar weighted distributions in the RANDS and NHIS. This result is as expected, since these variables are poststratification variables used to construct the sample (or original panel) weights in both NHIS and RANDS. As observed, persons with higher levels of education, with selected health conditions (i.e., diagnosed high cholesterol, diagnosed chronic obstructive pulmonary disease (COPD), emphysema, or chronic bronchitis, diagnosed diabetes, and diagnosed hypertension), who are current or former smokers, or who are not married (with the exception of those who are widowed) participated in RANDS at a higher rate compared to the NHIS. Since the percent of missing values across all considered variables was relatively low for both data sources, ranging from 0%-0.68% for RANDS and 0%-2.64% for NHIS (unweighted), missing values were excluded for evaluation.</p><p id="P56">To check for correlation between covariates, bivariate correlations were assessed on the weighted NHIS data. Bivariate correlations for all selected covariates were statistically significant. Prior to evaluating the propensity models, the survey weights for both data sets were normalized to their respective sample sizes (n=2,646 for RANDS, n=31,997 for NHIS) as suggested by <xref rid="R21" ref-type="bibr">Li et al. (2011)</xref> and <xref rid="R39" ref-type="bibr">Wang et al. (2021)</xref>. The KW method was implemented for demonstration to construct RANDS pseudo-weights that adjust for potential selection bias due to differential non-response and under-coverage of some groups on the sample frame using the NHIS data as the reference dataset.</p><p id="P57">A full propensity model (denoted by model.all) that includes all covariates and their pairwise interactions was used to create pseudo-weights. Due to the large number of parameters in the full model, estimated propensity scores can be unstable. As a result, some form of stepwise propensity model selection methods have been conducted in different studies (<xref rid="R40" ref-type="bibr">Weitzen et al., 2004</xref>; <xref rid="R2" ref-type="bibr">Austin 2008</xref>; <xref rid="R37" ref-type="bibr">Wang et al., 2020a</xref>), using the combined target sample and the reference sample to identify significant terms out of the full propensity model. In the framework of our paper, the combination of the confounders and selection predictors (i.e., model.x13 which contains <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub>), which can be main effects of covariates or their nonlinear/nonadditive combinations such as pairwise interactions, are recommended as terms for inclusion. Based on the simulation results, we expect that the pseudo-weighted mean under model.x13 would be unbiased but with higher variability when compared with the estimates under model.x12 that includes the confounders and outcome predictors.</p><p id="P58">Accordingly, we conducted the outcome model selection using backward selection on the reference survey (e.g., the 2019 NHIS), to identify terms which were confounders or outcome predictors. We defined the selected model as model.x12.n (contains <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub>) with &#x0201c;n&#x0201d; indicating that the outcome predictors were identified using the NHIS. However, it is often the case that the reference probability surveys have no collected information on the outcome variable. In this case, we have only the target sample (e.g., RANDS) available for outcome model selection. With the assumption of the conditional noninformative sampling of the target sample, it is expected the unweighted regression of the outcome would produce unbiased estimates of regression coefficients (<xref rid="R18" ref-type="bibr">Korn and Graubard, 1999</xref>). As follows, outcome model variable selection was conducted based on the unweighted outcome regression of the RANDS data, and the selected model included both confounders and outcome predictors, denoted by model.x12.r (contains <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub>) indicating that the outcome predictors were identified using RANDS. The common terms in model.x13 and model.x12 (denoted by either x12.n or x12.r based on the information available) are confounders, and the corresponding propensity model is denoted by model.x1. The identified covariate types under each model are reported in the <xref rid="APP1" ref-type="app">Appendix</xref>. Due to the correlation between x1, x2 and x3, we expect estimates under model.x1, albeit efficient, may not remove as much bias as under the model.x12 or model.x13.</p><p id="P59">The outcome models utilized the observations in the NHIS or the RANDS, whereas the propensity model utilized the observations in the combined NHIS and RANDS data, from which the estimated propensities were obtained and used for construction of the KW pseudo-weight for each individual in RANDS. Note that RANDS has panel weights, which were computed as an overall sampling weight for the selection of each panel member from the sampling frame and the selection of the panel member into RANDS. We considered two scenarios of 1) panel weights or 2) no panel weights for the propensity analysis.</p><p id="P60">Various propensity models that included different types of covariates were evaluated by the coefficient of variation (CV) of the KW pseudo-weights (<italic toggle="yes">CV</italic> = <italic toggle="yes">sd</italic>(<italic toggle="yes">KW</italic>)/<italic toggle="yes">mean</italic>(<italic toggle="yes">KW</italic>) with <italic toggle="yes">sd</italic> denoting standard deviation), relative bias (<inline-formula><mml:math id="M31" display="inline"><mml:mrow><mml:mtext>relBias</mml:mtext><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo stretchy="true">^</mml:mo></mml:mover><mml:mrow><mml:mi>R</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi><mml:mi>D</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub><mml:mo>&#x02212;</mml:mo><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo stretchy="true">^</mml:mo></mml:mover><mml:mrow><mml:mi>N</mml:mi><mml:mi>H</mml:mi><mml:mi>I</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo stretchy="true">^</mml:mo></mml:mover><mml:mrow><mml:mi>N</mml:mi><mml:mi>H</mml:mi><mml:mi>I</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:mfrac><mml:mo>&#x000d7;</mml:mo><mml:mn>100</mml:mn><mml:mo>%</mml:mo></mml:mrow></mml:math></inline-formula>), standard error (se), and mean squared error (<inline-formula><mml:math id="M32" display="inline"><mml:mrow><mml:mtext>MSE</mml:mtext><mml:mo>=</mml:mo><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mrow><mml:mi>R</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi><mml:mi>D</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub><mml:mo>&#x02212;</mml:mo><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mrow><mml:mi>N</mml:mi><mml:mi>H</mml:mi><mml:mi>I</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub><mml:msup><mml:mo stretchy="false">)</mml:mo><mml:mn>2</mml:mn></mml:msup><mml:mo>+</mml:mo><mml:mi>s</mml:mi><mml:msup><mml:mi>e</mml:mi><mml:mn>2</mml:mn></mml:msup><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mrow><mml:mi>R</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi><mml:mi>D</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula>). The relative bias was calculated as the estimated asthma prevalence in RANDS relative to the NHIS estimate where the RANDS estimate, <inline-formula><mml:math id="M33" display="inline"><mml:mrow><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mrow><mml:mi>R</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi><mml:mi>D</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math></inline-formula>, was calculated using the KW pseudo-weights produced from the various propensity models. The standard error <inline-formula><mml:math id="M34" display="inline"><mml:mrow><mml:mi>s</mml:mi><mml:mi>e</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:msub><mml:mover accent="true"><mml:mi>&#x003bc;</mml:mi><mml:mo>^</mml:mo></mml:mover><mml:mrow><mml:mi>R</mml:mi><mml:mi>A</mml:mi><mml:mi>N</mml:mi><mml:mi>D</mml:mi><mml:mi>S</mml:mi></mml:mrow></mml:msub><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:math></inline-formula> considered the variability due to estimating the propensity scores, sampling, kernel weighting, as well as differential pseudo-weights by the Taylor linearization method (<xref rid="R38" ref-type="bibr">Wang et al., 2020b</xref>). For comparison purposes, we also report the relative bias, standard error, and MSE of the original panel-weighted and unweighted estimates of asthma prevalence in RANDS 3. Results are presented in <xref rid="T4" ref-type="table">Table 4</xref>.</p><p id="P61">Four observations can be made from <xref rid="T3" ref-type="table">Table 3</xref>. <italic toggle="yes">Firstly</italic>, all 12 (panel-weighted or unweighted) propensity-adjusted estimates perform better, with a smaller MSE (or relative bias), compared to the original panel-weighted RANDS estimate of asthma prevalence without PS adjustment. When the RANDS panel weights are considered in the propensity analysis, the standard errors tend to be inflated, relative to those in the lower pane, due to more variable KW pseudo-weights with their CVs ranging from 1.07-1.13 (see the upper pane) <italic toggle="yes">vs.</italic> 0.69-0.83 (see the lower pane). Accordingly, observations 2-4 focus on the results in the lower panel when the panel weights are not used to construct KW pseudo-weights. <italic toggle="yes">Secondly</italic>, consistent with our expectations, the propensity models that contain confounders and selection variables, i.e. Model.x13, produce larger estimated variances compared with Model.x12 irrespective of the outcome predictors being selected from RANDS or the NHIS (e.g., se=0.97 vs. 0.81-0.84). <italic toggle="yes">Thirdly</italic>, comparing the estimates under the propensity models containing the confounders and outcome predictors that are selected using NHIS data (i.e. Model.x12.n) vs. the RANDS data (i.e. Model.x12.r), similar relative bias, se and MSE are observed (relBias = 11.38 vs. 11.37; se=0.81 vs. 0.84, MSE=3.01 vs. 3.04). <italic toggle="yes">Lastly</italic>, the relative biases under Model.x1 are somewhat larger than that under Model.x12 (relBias = 13.67 vs. 11.38 or 13.44 vs. 11.37). This result could be due to the existing correlation between the confounders and the outcome predictors. Adjusting for confounders only may not be sufficient for maximum bias reduction.</p><p id="P62">In brief, for the evaluation of diagnosed asthma using the RANDS data, we would recommend the pseudo-weights constructed under Model.x12.n with the confounders and predictors selected from the reference survey (e.g., NHIS). In situations where outcome variables are not collected in the reference survey but available only in the target sample (e.g., RANDS), Model.x12.r can be the alternative model to construct the KW pseudo-weights, assuming conditional noninformative sampling holds for the target sample.</p></sec><sec id="S12"><label>5.</label><title>Discussion</title><p id="P63">Identifying and collecting the best information on more timely target sample and on higher quality reference surveys can increase the ability of NSOs to produce timely estimates with lower bias from target samples. This paper examined how different types of variables that are included in a propensity model impact the performance of PS-based pseudo-weighted estimators for population mean estimation from a target sample. Means and variances of estimated population means under various mis-specified propensity models, including different types of variables with and without interactive effects, were evaluated analytically and numerically. Different levels of variable correlations in the finite population were also considered to reflect real data scenarios. We have the following findings: 1) confounders, the variables related to both the selection indicator and the outcome of interest, are important variables to include in the propensity model; 2) pseudo-weights that balance the distributions in the outcome predictor <italic toggle="yes">x</italic><sub>2</sub> or the selection variable <italic toggle="yes">x</italic><sub>3</sub>, in addition to the confounder <italic toggle="yes">x</italic><sub>1</sub>, denoted by <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>) or <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>), should be constructed for the target sample units so that the corresponding pseudo-weighted target sample mean is approximately unbiased; 3) compared to <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>3</sub>), the pseudo-weights <italic toggle="yes">w</italic>(<italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>) gain more efficiency in estimating population means. In contrast, the inclusion of selection variables, compared to the outcome predictors, in the propensity model tended to inflate the estimated variances. Intuitively, the outcome predictor is related to the outcome variable; including outcome predictors in the propensity score model distinguishes differences between the outcome in the reference and target samples, which results in weights related to outcome and therefore yields estimates with smaller variance estimates. Finally, findings are applied to real target data from RANDS, a survey that uses commercial probability panels, which has potential selection bias. Under the model with confounders and outcome predictors (Model.x12) or model with confounders and selection variables (Model.x13), the RANDS estimate of U.S. asthma prevalence had the greatest bias reduction (relative bias ranging from 11.37%-13.51% compared to the NHIS) when the panel weights are not used to construct KW pseudo-weights, compared to the original panel-weighted RANDS estimates (relative bias of 25.31%).</p><p id="P64">Results from this paper have several important applications in practice for NSOs that collect data from both target surveys and high-quality reference surveys. First, this study provides a principled approach to select covariates for the PS model. Rather than including all variables or selecting certain demographic variables, covariates are assessed based on their variable type (confounder, outcome predictor, selection variable) to be included in the PS model for population mean estimation. Second, guidance on how to design the questionnaire for a target survey with specific research questions (e.g., SARS-CoV2 seropositivity web survey by <xref rid="R15" ref-type="bibr">Kalish et al., 2021</xref>) is provided to survey practitioners. The attributes that are most effective in reducing bias/variances of estimates can be collected and used to reduce potential selection bias for the purpose of timely data collection and minimum response burden. Third, the findings from this study can be used for future development of a high-quality probability survey, including the planning of covariates to collect through paradata or the survey questionnaire with minimized measurement/reporting error, to be used as a high-quality reference survey by various nonprobability or web-based probability surveys with selection bias.</p><p id="P65">The proposed variable inclusion strategies have limitations that can be of interest for future research. First, the strategy is developed for single-outcome studies with research questions related to one outcome of interest, e.g., SARS-CoV2 seropositivity study (<xref rid="R15" ref-type="bibr">Kalish et al., 2021</xref>). The target sample was collected in a web survey with questions related to COVID-19 infection only. For studies with multiple key outcome variables, it would be of interest to study how the correlation among outcome variables, the overlap for each variable type across outcomes, and their interplays affect population mean estimation by different variable inclusion strategies. Second, in our simulation, we demonstrated the use of a PS matching method (KW) and a PS weighting method numerically. It showed that KW produced approximately unbiased estimates when the analytic propensity model is slightly mis-specified (without the interaction term) while the PS weighting methods require the true propensity model to obtain unbiased estimates. In practice, the underlying selection mechanism of the target sample is often complicated, involving higher orders of nonlinearity and/or nonadditivity. For complicated propensity models, only including main or interactive effects of blocking variables in the logistic model by KW methods may not be sufficient. Nonparametric modeling such as machine learning methods may be promising (<xref rid="R16" ref-type="bibr">Kern et al., 2020</xref>). Third, the focus of this paper was on evaluating the bias and variance reduction of Horvitz-Thompson estimators of FP mean by the types of covariates in the propensity model and thus we did not study how the pseudo-weights, when combined with different estimators, affect the FP mean estimation. Alternative analysis methods, such as doubly robust estimators (Chen, Li and Wu, 2018) or augmented estimation equations in the missing data imputation context (<xref rid="R33" ref-type="bibr">Robins, Rotnitzky and Zhao, 1994</xref>) can be employed, after identifying the appropriate type of variables to include in the propensity score model. Fourth, selection bias in target samples, compared to more rigorous probability samples, can be induced by low response, different question wording/ordering, topic salience for different types of questions (for example health and health conditions can have large selection bias as shown in <xref rid="T2" ref-type="table">Table 2</xref>). It would be interesting to study how the proposed variable inclusion strategy can be adapted to reduce the selection bias in target samples with different response rates, question order/wording and salience effects. Lastly, in our data example the backward selection is employed for identifying the type of variables. It would be interesting to employ and compare alternative variable selection methods such as AIC or BIC (<xref rid="R24" ref-type="bibr">Lumley and Scott, 2015</xref>) that incorporate complex sample designs for the model selection.</p></sec></body><back><ack id="S13"><title>Disclaimer:</title><p id="P66">The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the National Center for Health Statistics, Centers for Disease Control and Prevention.</p></ack><app-group><app id="APP1"><label>Appendix:</label><title>Real Data Analysis Covariate Types</title><p id="P67">Covariate types (X<sub>1</sub>, confounder; X<sub>2</sub>, predictor; X<sub>3</sub>, selection indicator) reported for each model covariate used in the real data analysis (<xref rid="S11" ref-type="sec">Section 4</xref>). Covariate interactions are denoted by *. Eleven predictors (age group; sex; race/ethnicity; marital status; education level; smoking status; diagnosed with high cholesterol; diagnosed with COPD, emphysema, or chronic bronchitis; diagnosed with diabetes; diagnosed with hypertension; and employment status) and their pairwise interactions were included in the initial propensity score models for all adjustments. The covariate types are reported by model set up including the inclusion of RANDS panel weights (panel weights) and exclusion of RANDS panel weights (no weights). Model.n indicates that the outcome predictors were identified using the NHIS; Model.r indicates that the outcome predictors were identified using RANDS.</p><table-wrap position="anchor" id="T5"><table frame="void" rules="none"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="bottom" rowspan="1" colspan="1"/><th align="left" valign="bottom" rowspan="1" colspan="1"/><th colspan="4" align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1">Covariate Type</th></tr><tr><th align="left" valign="bottom" rowspan="1" colspan="1"/><th align="left" valign="bottom" rowspan="1" colspan="1"/><th colspan="2" align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1">Panel weights</th><th colspan="2" align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1">No weights</th></tr><tr><th align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><th align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Variable</th><th align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Model.n</th><th align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Model.r</th><th align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Model.n</th><th align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Model.r</th></tr></thead><tbody><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">1</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years)</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">2</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">3</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">4</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">5</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Education level</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">6</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Smoking status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">7</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with high cholesterol</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">8</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">9</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">10</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">11</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">12</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Sex</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">13</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Race/Ethnicity</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">14</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Marital status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">15</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Education level</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">16</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Smoking status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">17</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Diagnosed with high cholesterol</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">18</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">19</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">20</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">21</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Age group (years) * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">22</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Race/Ethnicity</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">23</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Marital status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">24</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Education level</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">25</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Smoking status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">26</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Diagnosed with high cholesterol</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">27</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">28</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">29</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">30</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Sex * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">31</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Marital status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>1</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">32</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Education level</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">33</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Smoking status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">34</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Diagnosed with high cholesterol</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">35</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">36</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">37</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">38</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Race/Ethnicity * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">39</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status * Education level</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">40</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status * Smoking status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">41</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status * Diagnosed with high cholesterol</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">42</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status * Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">43</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">44</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">45</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Marital status * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">46</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Education level * Smoking status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">47</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Education level * Diagnosed with high cholesterol</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">48</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Education level * Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">49</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Education level * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">50</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Education level * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">51</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Education level * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">52</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Smoking status * Diagnosed with high cholesterol</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">53</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Smoking status * Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">54</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Smoking status * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">55</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Smoking status * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">56</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Smoking status * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">57</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with high cholesterol * Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">58</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with high cholesterol * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">59</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with high cholesterol * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">60</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with high cholesterol * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>3</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">61</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with COPD, emphysema, or chronic bronchitis * Diagnosed with diabetes</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">X<sub>2</sub></td></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">62</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with COPD, emphysema, or chronic bronchitis * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">63</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with COPD, emphysema, or chronic bronchitis * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">64</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with diabetes * Diagnosed with hypertension</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">65</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with diabetes * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/></tr><tr><td align="center" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">66</td><td align="left" valign="bottom" style="border-bottom: solid 1px" rowspan="1" colspan="1">Diagnosed with hypertension * Employment status</td><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1"/><td align="center" valign="middle" 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Blocking dotted path(s) to have <italic toggle="yes">Y</italic> &#x022a5; <italic toggle="yes">A</italic>.</p></caption><graphic xlink:href="nihms-1807439-f0002" position="float"/></fig><fig position="float" id="F3"><label>Figure 3.</label><caption><p id="P70">Bias of Kernel Weighting (KW) vs. Adjusted Logistic Propensity (ALP) Estimated under Various Propensity Models with w(<italic toggle="yes">x</italic><sub>12</sub>), w(<italic toggle="yes">x</italic><sub>13</sub>), w(<italic toggle="yes">x</italic><sub>1</sub> * <italic toggle="yes">x</italic><sub>2</sub>), and w(<italic toggle="yes">x</italic><sub>1</sub> * <italic toggle="yes">x</italic><sub>3</sub>) including, respectively, main effects of <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub>, main effects of <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub>, main and interactive effects of <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>2</sub>, and main and interactive effects of <italic toggle="yes">X</italic><sub>1</sub> and <italic toggle="yes">X</italic><sub>3</sub>, with (<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (0,0,0) (a), (0,.6,0) (b), (.6,.6,0) (c), and (.6,.6,.6) (d), to cover 0, 1, 2, and 3 pair(s) of covariate correlations in the FP, and interactive effects <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = 0.5. Propensity model with w(<italic toggle="yes">x</italic><sub>1</sub> * <italic toggle="yes">x</italic><sub>3</sub>) is the true model.</p></caption><graphic xlink:href="nihms-1807439-f0003" position="float"/></fig><table-wrap position="float" id="T1"><label>Table 1.</label><caption><p id="P71">Results from population mean estimation<sup><xref rid="TFN1" ref-type="table-fn">1</xref></sup> under various propensity score models<sup><xref rid="TFN2" ref-type="table-fn">2</xref></sup> with covariate correlations (<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (0, 0, 0) and interaction effects <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = 0.</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="top" rowspan="1" colspan="1"/><th align="left" valign="top" rowspan="1" colspan="1">Sample<sup><xref rid="TFN3" ref-type="table-fn">3</xref></sup></th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>1</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>2</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>3</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>12</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>13</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>23</sub>)</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">4.61</td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">4.50</td><td align="left" valign="top" rowspan="1" colspan="1">4.83</td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">0.41</td><td align="left" valign="top" rowspan="1" colspan="1">4.77</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">2.20</td><td align="left" valign="top" rowspan="1" colspan="1">2.68</td><td align="left" valign="top" rowspan="1" colspan="1">2.62</td><td align="left" valign="top" rowspan="1" colspan="1">2.96</td><td align="left" valign="top" rowspan="1" colspan="1">2.92</td><td align="left" valign="top" rowspan="1" colspan="1">3.43</td><td align="left" valign="top" rowspan="1" colspan="1">3.32</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">23.48</td><td align="left" valign="top" rowspan="1" colspan="1">2.75</td><td align="left" valign="top" rowspan="1" colspan="1">22.85</td><td align="left" valign="top" rowspan="1" colspan="1">26.31</td><td align="left" valign="top" rowspan="1" colspan="1">2.99</td><td align="left" valign="top" rowspan="1" colspan="1">3.60</td><td align="left" valign="top" rowspan="1" colspan="1">26.04</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>1</label><p id="P72">Kernel weighting estimator (<xref rid="R38" ref-type="bibr">Wang et al., 2020b</xref>) is applied for population mean estimation.</p></fn><fn id="TFN2"><label>2</label><p id="P73">w(<italic toggle="yes">x</italic><sub>1</sub>), w(<italic toggle="yes">x</italic><sub>2</sub>), w(<italic toggle="yes">x</italic><sub>3</sub>), w(<italic toggle="yes">x</italic><sub>12</sub>), w(<italic toggle="yes">x</italic><sub>13</sub>), and w(<italic toggle="yes">x</italic><sub>23</sub>) denote pseudo-weighted means with pseudo-weights constructed under the propensity model with main effect(s) of <italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>3</sub>, <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>3</sub>, and <italic toggle="yes">x</italic><sub>2</sub> and <italic toggle="yes">x</italic><sub>3</sub>, respectively.</p></fn><fn id="TFN3"><label>3</label><p id="P74">sample denotes the unweighted mean</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="T2"><label>Table 2.</label><caption><p id="P75">Results from population mean estimation<sup><xref rid="TFN4" ref-type="table-fn">1</xref></sup> under various propensity score models<sup><xref rid="TFN5" ref-type="table-fn">2</xref></sup> by covariate correlations with interaction effects <italic toggle="yes">&#x003b1;</italic><sub>12</sub> = <italic toggle="yes">&#x003b2;</italic><sub>13</sub> = 0.</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="top" rowspan="1" colspan="1"/><th align="left" valign="top" rowspan="1" colspan="1">Sample<sup><xref rid="TFN6" ref-type="table-fn">3</xref></sup></th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>1</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>2</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>3</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>12</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>13</sub>)</th><th align="left" valign="top" rowspan="1" colspan="1">w(<italic toggle="yes">x</italic><sub>23</sub>)</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="6" align="center" valign="top" rowspan="1">(<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (.6, 0, 0)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">7.35</td><td align="left" valign="top" rowspan="1" colspan="1">0.37</td><td align="left" valign="top" rowspan="1" colspan="1">2.98</td><td align="left" valign="top" rowspan="1" colspan="1">7.60</td><td align="left" valign="top" rowspan="1" colspan="1">0.37</td><td align="left" valign="top" rowspan="1" colspan="1">0.59</td><td align="left" valign="top" rowspan="1" colspan="1">3.25</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">2.15</td><td align="left" valign="top" rowspan="1" colspan="1">2.59</td><td align="left" valign="top" rowspan="1" colspan="1">2.64</td><td align="left" valign="top" rowspan="1" colspan="1">2.77</td><td align="left" valign="top" rowspan="1" colspan="1">2.66</td><td align="left" valign="top" rowspan="1" colspan="1">2.88</td><td align="left" valign="top" rowspan="1" colspan="1">2.84</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">56.14</td><td align="left" valign="top" rowspan="1" colspan="1">2.72</td><td align="left" valign="top" rowspan="1" colspan="1">11.52</td><td align="left" valign="top" rowspan="1" colspan="1">60.57</td><td align="left" valign="top" rowspan="1" colspan="1">2.79</td><td align="left" valign="top" rowspan="1" colspan="1">3.23</td><td align="left" valign="top" rowspan="1" colspan="1">13.42</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="6" align="center" valign="top" rowspan="1">(<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (0, .6, 0)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">7.27</td><td align="left" valign="top" rowspan="1" colspan="1">0.32</td><td align="left" valign="top" rowspan="1" colspan="1">7.16</td><td align="left" valign="top" rowspan="1" colspan="1">3.21</td><td align="left" valign="top" rowspan="1" colspan="1">0.30</td><td align="left" valign="top" rowspan="1" colspan="1">0.41</td><td align="left" valign="top" rowspan="1" colspan="1">3.12</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">2.17</td><td align="left" valign="top" rowspan="1" colspan="1">3.60</td><td align="left" valign="top" rowspan="1" colspan="1">2.39</td><td align="left" valign="top" rowspan="1" colspan="1">3.68</td><td align="left" valign="top" rowspan="1" colspan="1">3.53</td><td align="left" valign="top" rowspan="1" colspan="1">4.05</td><td align="left" valign="top" rowspan="1" colspan="1">3.66</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">54.98</td><td align="left" valign="top" rowspan="1" colspan="1">3.70</td><td align="left" valign="top" rowspan="1" colspan="1">53.67</td><td align="left" valign="top" rowspan="1" colspan="1">13.97</td><td align="left" valign="top" rowspan="1" colspan="1">3.62</td><td align="left" valign="top" rowspan="1" colspan="1">4.22</td><td align="left" valign="top" rowspan="1" colspan="1">13.39</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="6" align="center" valign="top" rowspan="1">(<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (0, 0, .6)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">7.55</td><td align="left" valign="top" rowspan="1" colspan="1">2.98</td><td align="left" valign="top" rowspan="1" colspan="1">4.65</td><td align="left" valign="top" rowspan="1" colspan="1">4.87</td><td align="left" valign="top" rowspan="1" colspan="1">0.26</td><td align="left" valign="top" rowspan="1" colspan="1">0.37</td><td align="left" valign="top" rowspan="1" colspan="1">4.83</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">2.01</td><td align="left" valign="top" rowspan="1" colspan="1">2.52</td><td align="left" valign="top" rowspan="1" colspan="1">2.38</td><td align="left" valign="top" rowspan="1" colspan="1">2.57</td><td align="left" valign="top" rowspan="1" colspan="1">2.66</td><td align="left" valign="top" rowspan="1" colspan="1">2.75</td><td align="left" valign="top" rowspan="1" colspan="1">2.66</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">59.00</td><td align="left" valign="top" rowspan="1" colspan="1">11.38</td><td align="left" valign="top" rowspan="1" colspan="1">24.00</td><td align="left" valign="top" rowspan="1" colspan="1">26.30</td><td align="left" valign="top" rowspan="1" colspan="1">2.73</td><td align="left" valign="top" rowspan="1" colspan="1">2.89</td><td align="left" valign="top" rowspan="1" colspan="1">26.03</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="6" align="center" valign="top" rowspan="1">(<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (.6, .6, 0)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">9.81</td><td align="left" valign="top" rowspan="1" colspan="1">&#x02212;1.04</td><td align="left" valign="top" rowspan="1" colspan="1">5.36</td><td align="left" valign="top" rowspan="1" colspan="1">6.09</td><td align="left" valign="top" rowspan="1" colspan="1">0.54</td><td align="left" valign="top" rowspan="1" colspan="1">0.54</td><td align="left" valign="top" rowspan="1" colspan="1">1.70</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">2.16</td><td align="left" valign="top" rowspan="1" colspan="1">3.45</td><td align="left" valign="top" rowspan="1" colspan="1">2.94</td><td align="left" valign="top" rowspan="1" colspan="1">3.79</td><td align="left" valign="top" rowspan="1" colspan="1">3.94</td><td align="left" valign="top" rowspan="1" colspan="1">3.98</td><td align="left" valign="top" rowspan="1" colspan="1">4.19</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">98.39</td><td align="left" valign="top" rowspan="1" colspan="1">4.52</td><td align="left" valign="top" rowspan="1" colspan="1">31.61</td><td align="left" valign="top" rowspan="1" colspan="1">40.93</td><td align="left" valign="top" rowspan="1" colspan="1">4.23</td><td align="left" valign="top" rowspan="1" colspan="1">4.27</td><td align="left" valign="top" rowspan="1" colspan="1">7.09</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="6" align="center" valign="top" rowspan="1">(<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (.6, 0, .6)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">10.27</td><td align="left" valign="top" rowspan="1" colspan="1">3.11</td><td align="left" valign="top" rowspan="1" colspan="1">1.67</td><td align="left" valign="top" rowspan="1" colspan="1">7.60</td><td align="left" valign="top" rowspan="1" colspan="1">0.50</td><td align="left" valign="top" rowspan="1" colspan="1">0.60</td><td align="left" valign="top" rowspan="1" colspan="1">2.36</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">2.33</td><td align="left" valign="top" rowspan="1" colspan="1">2.84</td><td align="left" valign="top" rowspan="1" colspan="1">2.96</td><td align="left" valign="top" rowspan="1" colspan="1">2.94</td><td align="left" valign="top" rowspan="1" colspan="1">2.93</td><td align="left" valign="top" rowspan="1" colspan="1">3.11</td><td align="left" valign="top" rowspan="1" colspan="1">3.00</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">107.86</td><td align="left" valign="top" rowspan="1" colspan="1">12.51</td><td align="left" valign="top" rowspan="1" colspan="1">5.76</td><td align="left" valign="top" rowspan="1" colspan="1">60.72</td><td align="left" valign="top" rowspan="1" colspan="1">3.18</td><td align="left" valign="top" rowspan="1" colspan="1">3.46</td><td align="left" valign="top" rowspan="1" colspan="1">8.58</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="6" align="center" valign="top" rowspan="1">(<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (0, .6, .6)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">10.09</td><td align="left" valign="top" rowspan="1" colspan="1">3.11</td><td align="left" valign="top" rowspan="1" colspan="1">7.24</td><td align="left" valign="top" rowspan="1" colspan="1">1.56</td><td align="left" valign="top" rowspan="1" colspan="1">0.33</td><td align="left" valign="top" rowspan="1" colspan="1">0.44</td><td align="left" valign="top" rowspan="1" colspan="1">2.34</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">1.98</td><td align="left" valign="top" rowspan="1" colspan="1">3.65</td><td align="left" valign="top" rowspan="1" colspan="1">2.63</td><td align="left" valign="top" rowspan="1" colspan="1">3.28</td><td align="left" valign="top" rowspan="1" colspan="1">3.45</td><td align="left" valign="top" rowspan="1" colspan="1">3.61</td><td align="left" valign="top" rowspan="1" colspan="1">3.48</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">103.83</td><td align="left" valign="top" rowspan="1" colspan="1">13.33</td><td align="left" valign="top" rowspan="1" colspan="1">54.98</td><td align="left" valign="top" rowspan="1" colspan="1">5.71</td><td align="left" valign="top" rowspan="1" colspan="1">3.55</td><td align="left" valign="top" rowspan="1" colspan="1">3.80</td><td align="left" valign="top" rowspan="1" colspan="1">8.97</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="6" align="center" valign="top" rowspan="1">(<italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>2</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>1</sub><italic toggle="yes">x</italic><sub>3</sub></sub>, <italic toggle="yes">&#x003c1;</italic><sub><italic toggle="yes">x</italic><sub>2</sub><italic toggle="yes">x</italic><sub>3</sub></sub>) = (.6, .6, .6)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bias (&#x000d7;10<sup>2</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">13.28</td><td align="left" valign="top" rowspan="1" colspan="1">1.73</td><td align="left" valign="top" rowspan="1" colspan="1">4.52</td><td align="left" valign="top" rowspan="1" colspan="1">4.81</td><td align="left" valign="top" rowspan="1" colspan="1">0.77</td><td align="left" valign="top" rowspan="1" colspan="1">0.89</td><td align="left" valign="top" rowspan="1" colspan="1">3.30</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">EmpVar (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">1.98</td><td align="left" valign="top" rowspan="1" colspan="1">3.93</td><td align="left" valign="top" rowspan="1" colspan="1">3.39</td><td align="left" valign="top" rowspan="1" colspan="1">3.88</td><td align="left" valign="top" rowspan="1" colspan="1">3.91</td><td align="left" valign="top" rowspan="1" colspan="1">4.29</td><td align="left" valign="top" rowspan="1" colspan="1">3.97</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">MSE (&#x000d7;10<sup>4</sup>)</td><td align="left" valign="top" rowspan="1" colspan="1">178.29</td><td align="left" valign="top" rowspan="1" colspan="1">6.91</td><td align="left" valign="top" rowspan="1" colspan="1">23.83</td><td align="left" valign="top" rowspan="1" colspan="1">26.99</td><td align="left" valign="top" rowspan="1" colspan="1">4.50</td><td align="left" valign="top" rowspan="1" colspan="1">5.07</td><td align="left" valign="top" rowspan="1" colspan="1">14.88</td></tr></tbody></table><table-wrap-foot><fn id="TFN4"><label>1</label><p id="P76">Kernel weighting estimator (<xref rid="R38" ref-type="bibr">Wang et al., 2020b</xref>) is applied for population mean estimation.</p></fn><fn id="TFN5"><label>2</label><p id="P77">w(<italic toggle="yes">x</italic><sub>1</sub>), w(<italic toggle="yes">x</italic><sub>2</sub>), w(<italic toggle="yes">x</italic><sub>3</sub>), w(<italic toggle="yes">x</italic><sub>12</sub>), w(<italic toggle="yes">x</italic><sub>13</sub>), and w(<italic toggle="yes">x</italic><sub>23</sub>) denote pseudo-weighted means with pseudo-weights constructed under the propensity model with main effect(s) of <italic toggle="yes">x</italic><sub>1</sub>, <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>3</sub>, <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>2</sub>, <italic toggle="yes">x</italic><sub>1</sub> and <italic toggle="yes">x</italic><sub>3</sub>, and <italic toggle="yes">x</italic><sub>2</sub> and <italic toggle="yes">x</italic><sub>3</sub>, respectively.</p></fn><fn id="TFN6"><label>3</label><p id="P78">sample denotes the unweighted mean.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="T3"><label>Table 3.</label><caption><p id="P79">Distribution of selected covariates and asthma in the Research and Development Survey (RANDS) 3 and the 2019 National Health Interview Survey (NHIS)</p></caption><table frame="void" rules="none"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Variable</th><th rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Subgroup</th><th align="left" valign="top" rowspan="1" colspan="1"/><th colspan="2" align="left" valign="middle" rowspan="1">RANDS (n=2,646)</th><th colspan="2" align="left" valign="middle" rowspan="1">NHIS (n=31,997)</th></tr><tr><th align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">N</th><th align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">%</th><th align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Wt %</th><th align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">n</th><th align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Wt %</th></tr></thead><tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1">
<bold>Outcome</bold>
</td><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Ever diagnosed with asthma</td><td align="left" valign="middle" rowspan="1" colspan="1">Yes</td><td align="left" valign="middle" rowspan="1" colspan="1">431</td><td align="left" valign="middle" rowspan="1" colspan="1">16.4</td><td align="left" valign="middle" rowspan="1" colspan="1">16.9</td><td align="left" valign="middle" rowspan="1" colspan="1">4,229</td><td align="left" valign="middle" rowspan="1" colspan="1">13.5</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">No</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">2,197</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">83.6</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">83.1</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">27,718</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">86.5</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">
<bold>Covariates</bold>
</td><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/><td align="left" valign="middle" rowspan="1" colspan="1"/></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Age group (years)</td><td align="left" valign="middle" rowspan="1" colspan="1">18-34</td><td align="left" valign="middle" rowspan="1" colspan="1">721</td><td align="left" valign="middle" rowspan="1" colspan="1">27.2</td><td align="left" valign="middle" rowspan="1" colspan="1">29.9</td><td align="left" valign="middle" rowspan="1" colspan="1">7,058</td><td align="left" valign="middle" rowspan="1" colspan="1">29.7</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">35-49</td><td align="left" valign="middle" rowspan="1" colspan="1">652</td><td align="left" valign="middle" rowspan="1" colspan="1">24.6</td><td align="left" valign="middle" rowspan="1" colspan="1">24.1</td><td align="left" valign="middle" rowspan="1" colspan="1">7,250</td><td align="left" valign="middle" rowspan="1" colspan="1">24.3</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">50-64</td><td align="left" valign="middle" rowspan="1" colspan="1">687</td><td align="left" valign="middle" rowspan="1" colspan="1">26.0</td><td align="left" valign="middle" rowspan="1" colspan="1">25.1</td><td align="left" valign="middle" rowspan="1" colspan="1">8,313</td><td align="left" valign="middle" rowspan="1" colspan="1">24.9</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">65+</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">586</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">22.1</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">20.9</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">9,376</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">21.1</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Sex</td><td align="left" valign="middle" rowspan="1" colspan="1">Male</td><td align="left" valign="middle" rowspan="1" colspan="1">1,318</td><td align="left" valign="middle" rowspan="1" colspan="1">49.8</td><td align="left" valign="middle" rowspan="1" colspan="1">48.3</td><td align="left" valign="middle" rowspan="1" colspan="1">14,733</td><td align="left" valign="middle" rowspan="1" colspan="1">48.3</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Female</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">1,328</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">50.2</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">51.7</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">17,261</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">51.7</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Race/Ethnicity</td><td align="left" valign="middle" rowspan="1" colspan="1">Non-Hispanic white</td><td align="left" valign="middle" rowspan="1" colspan="1">1,729</td><td align="left" valign="middle" rowspan="1" colspan="1">65.3</td><td align="left" valign="middle" rowspan="1" colspan="1">63.1</td><td align="left" valign="middle" rowspan="1" colspan="1">21,915</td><td align="left" valign="middle" rowspan="1" colspan="1">63.2</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Non-Hispanic black</td><td align="left" valign="middle" rowspan="1" colspan="1">273</td><td align="left" valign="middle" rowspan="1" colspan="1">10.3</td><td align="left" valign="middle" rowspan="1" colspan="1">11.9</td><td align="left" valign="middle" rowspan="1" colspan="1">3,483</td><td align="left" valign="middle" rowspan="1" colspan="1">11.8</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Non-Hispanic other</td><td align="left" valign="middle" rowspan="1" colspan="1">227</td><td align="left" valign="middle" rowspan="1" colspan="1">8.6</td><td align="left" valign="middle" rowspan="1" colspan="1">8.5</td><td align="left" valign="middle" rowspan="1" colspan="1">2,447</td><td align="left" valign="middle" rowspan="1" colspan="1">8.5</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Hispanic</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">417</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">15.8</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">16.5</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">4,152</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">16.5</td></tr><tr><td rowspan="6" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Marital status</td><td align="left" valign="middle" rowspan="1" colspan="1">Married</td><td align="left" valign="middle" rowspan="1" colspan="1">1,282</td><td align="left" valign="middle" rowspan="1" colspan="1">48.5</td><td align="left" valign="middle" rowspan="1" colspan="1">47.7</td><td align="left" valign="middle" rowspan="1" colspan="1">14,759</td><td align="left" valign="middle" rowspan="1" colspan="1">52.4</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Widowed</td><td align="left" valign="middle" rowspan="1" colspan="1">134</td><td align="left" valign="middle" rowspan="1" colspan="1">5.1</td><td align="left" valign="middle" rowspan="1" colspan="1">4.5</td><td align="left" valign="middle" rowspan="1" colspan="1">3,115</td><td align="left" valign="middle" rowspan="1" colspan="1">6.0</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Divorced</td><td align="left" valign="middle" rowspan="1" colspan="1">350</td><td align="left" valign="middle" rowspan="1" colspan="1">13.2</td><td align="left" valign="middle" rowspan="1" colspan="1">12.4</td><td align="left" valign="middle" rowspan="1" colspan="1">4,317</td><td align="left" valign="middle" rowspan="1" colspan="1">9.0</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Separated</td><td align="left" valign="middle" rowspan="1" colspan="1">50</td><td align="left" valign="middle" rowspan="1" colspan="1">1.9</td><td align="left" valign="middle" rowspan="1" colspan="1">1.8</td><td align="left" valign="middle" rowspan="1" colspan="1">456</td><td align="left" valign="middle" rowspan="1" colspan="1">1.2</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Never married</td><td align="left" valign="middle" rowspan="1" colspan="1">618</td><td align="left" valign="middle" rowspan="1" colspan="1">23.4</td><td align="left" valign="middle" rowspan="1" colspan="1">24.3</td><td align="left" valign="middle" rowspan="1" colspan="1">6,368</td><td align="left" valign="middle" rowspan="1" colspan="1">22.5</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Living with partner</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">212</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">8.0</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">9.3</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">2,136</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">8.9</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Education level</td><td align="left" valign="middle" rowspan="1" colspan="1">High school diploma or less</td><td align="left" valign="middle" rowspan="1" colspan="1">577</td><td align="left" valign="middle" rowspan="1" colspan="1">21.8</td><td align="left" valign="middle" rowspan="1" colspan="1">38.8</td><td align="left" valign="middle" rowspan="1" colspan="1">11,155</td><td align="left" valign="middle" rowspan="1" colspan="1">39.9</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Some college</td><td align="left" valign="middle" rowspan="1" colspan="1">1,222</td><td align="left" valign="middle" rowspan="1" colspan="1">46.2</td><td align="left" valign="middle" rowspan="1" colspan="1">27.7</td><td align="left" valign="middle" rowspan="1" colspan="1">9,386</td><td align="left" valign="middle" rowspan="1" colspan="1">31.1</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Bachelor's degree or more</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">847</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">32.0</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">33.5</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">11,277</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">29.0</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Smoking status<sup><xref rid="TFN13" ref-type="table-fn">1</xref></sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Current</td><td align="left" valign="middle" rowspan="1" colspan="1">409</td><td align="left" valign="middle" rowspan="1" colspan="1">15.5</td><td align="left" valign="middle" rowspan="1" colspan="1">17.2</td><td align="left" valign="middle" rowspan="1" colspan="1">4,296</td><td align="left" valign="middle" rowspan="1" colspan="1">14.0</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Former</td><td align="left" valign="middle" rowspan="1" colspan="1">811</td><td align="left" valign="middle" rowspan="1" colspan="1">30.8</td><td align="left" valign="middle" rowspan="1" colspan="1">28.9</td><td align="left" valign="middle" rowspan="1" colspan="1">7,973</td><td align="left" valign="middle" rowspan="1" colspan="1">22.5</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Never</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">1,411</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">53.6</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">53.9</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">18,931</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">63.5</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Diagnosed with high cholesterol</td><td align="left" valign="middle" rowspan="1" colspan="1">Yes</td><td align="left" valign="middle" rowspan="1" colspan="1">976</td><td align="left" valign="middle" rowspan="1" colspan="1">37.1</td><td align="left" valign="middle" rowspan="1" colspan="1">36.4</td><td align="left" valign="middle" rowspan="1" colspan="1">9,179</td><td align="left" valign="middle" rowspan="1" colspan="1">24.9</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">No</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">1,657</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">62.9</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">63.6</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">22,697</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">75.1</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Diagnosed with COPD, emphysema, or chronic bronchitis</td><td align="left" valign="middle" rowspan="1" colspan="1">Yes</td><td align="left" valign="middle" rowspan="1" colspan="1">213</td><td align="left" valign="middle" rowspan="1" colspan="1">8.1</td><td align="left" valign="middle" rowspan="1" colspan="1">8.4</td><td align="left" valign="middle" rowspan="1" colspan="1">1,787</td><td align="left" valign="middle" rowspan="1" colspan="1">4.6</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">No</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">2,420</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">91.9</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">91.6</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">30,158</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">95.4</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Diagnosed with diabetes<sup><xref rid="TFN14" ref-type="table-fn">2</xref></sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Yes</td><td align="left" valign="middle" rowspan="1" colspan="1">279</td><td align="left" valign="middle" rowspan="1" colspan="1">10.6</td><td align="left" valign="middle" rowspan="1" colspan="1">10.5</td><td align="left" valign="middle" rowspan="1" colspan="1">3,355</td><td align="left" valign="middle" rowspan="1" colspan="1">9.3</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">No</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">2,352</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">89.4</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">89.5</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">28,594</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">90.7</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Diagnosed with hypertension</td><td align="left" valign="middle" rowspan="1" colspan="1">Yes</td><td align="left" valign="middle" rowspan="1" colspan="1">989</td><td align="left" valign="middle" rowspan="1" colspan="1">37.5</td><td align="left" valign="middle" rowspan="1" colspan="1">37.0</td><td align="left" valign="middle" rowspan="1" colspan="1">11,480</td><td align="left" valign="middle" rowspan="1" colspan="1">31.7</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">No</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">1,648</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">62.5</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">63.0</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">20,458</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">68.3</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom: solid 1px" colspan="1">Employment status</td><td align="left" valign="middle" rowspan="1" colspan="1">Paid employee</td><td align="left" valign="middle" rowspan="1" colspan="1">1,630</td><td align="left" valign="middle" rowspan="1" colspan="1">61.6</td><td align="left" valign="middle" rowspan="1" colspan="1">58.6</td><td align="left" valign="middle" rowspan="1" colspan="1">18,810</td><td align="left" valign="middle" rowspan="1" colspan="1">64.6</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Looking for work</td><td align="left" valign="middle" rowspan="1" colspan="1">166</td><td align="left" valign="middle" rowspan="1" colspan="1">6.3</td><td align="left" valign="middle" rowspan="1" colspan="1">7.2</td><td align="left" valign="middle" rowspan="1" colspan="1">485</td><td align="left" valign="middle" rowspan="1" colspan="1">2.0</td></tr><tr><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">Not looking for work</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">850</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">32.1</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">34.2</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">11,919</td><td align="left" valign="middle" style="border-bottom: solid 1px" rowspan="1" colspan="1">33.4</td></tr></tbody></table><table-wrap-foot><fn id="TFN12"><p id="P80">Notes: n=unweighted sample size, %=unweighted percent, Wt % = weighted percent</p></fn><fn id="TFN13"><label>1</label><p id="P81">Smoking status: Current smoker is defined as someone who has smoked at least 100 cigarettes in their lifetime and now smokes every day or some days. Former smoker is defined as someone who has smoked at least 100 cigarettes in their lifetime and now does not smoke. Never smokers are defined as persons who have smoked less than 100 cigarettes in their lifetime.</p></fn><fn id="TFN14"><label>2</label><p id="P82">Diagnosed diabetes excludes pre-diabetes and gestational diabetes.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="T4"><label>Table 4.</label><caption><p id="P83">Analysis Results for estimation of the prevalence of diagnosed asthma for adults from RANDS 3 under various propensity models and RANDS 3 weights</p></caption><table frame="void" rules="none"><colgroup span="1"><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/><col align="left" valign="middle" span="1"/></colgroup><thead><tr><th align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Propensity model<sup><xref rid="TFN7" ref-type="table-fn">1</xref></sup></th><th align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">CV<sup><xref rid="TFN8" ref-type="table-fn">2</xref></sup>(KW)</th><th align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">relBias<sup><xref rid="TFN9" ref-type="table-fn">3</xref></sup> (%)</th><th align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">se<sup><xref rid="TFN10" ref-type="table-fn">4</xref></sup> (&#x000d7; 10<sup>2</sup>)</th><th align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">MSE<sup><xref rid="TFN11" ref-type="table-fn">5</xref></sup> (&#x000d7; 10<sup>4</sup>)</th></tr></thead><tbody><tr><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Original panel-weighted</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">0.91</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">25.31</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">0.98</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">12.56</td></tr><tr><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Unweighted</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">0</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">21.89</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">0.72</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">9.19</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="4" align="left" valign="top" rowspan="1">panel weights</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.all</td><td align="left" valign="top" rowspan="1" colspan="1">1.13</td><td align="left" valign="top" rowspan="1" colspan="1">17.55</td><td align="left" valign="top" rowspan="1" colspan="1">1.21</td><td align="left" valign="top" rowspan="1" colspan="1">7.04</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x13</td><td align="left" valign="top" rowspan="1" colspan="1">1.10</td><td align="left" valign="top" rowspan="1" colspan="1">13.35</td><td align="left" valign="top" rowspan="1" colspan="1">1.04</td><td align="left" valign="top" rowspan="1" colspan="1">4.31</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x12.n</td><td align="left" valign="top" rowspan="1" colspan="1">1.07</td><td align="left" valign="top" rowspan="1" colspan="1">11.41</td><td align="left" valign="top" rowspan="1" colspan="1">0.93</td><td align="left" valign="top" rowspan="1" colspan="1">3.23</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x1.n</td><td align="left" valign="top" rowspan="1" colspan="1">1.07</td><td align="left" valign="top" rowspan="1" colspan="1">12.38</td><td align="left" valign="top" rowspan="1" colspan="1">0.95</td><td align="left" valign="top" rowspan="1" colspan="1">3.67</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x12.r</td><td align="left" valign="top" rowspan="1" colspan="1">1.08</td><td align="left" valign="top" rowspan="1" colspan="1">12.85</td><td align="left" valign="top" rowspan="1" colspan="1">0.97</td><td align="left" valign="top" rowspan="1" colspan="1">3.94</td></tr><tr><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Model.x1.r</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">1.08</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">12.85</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">0.97</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">3.93</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"/><td colspan="4" align="left" valign="top" rowspan="1">no weights</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.all</td><td align="left" valign="top" rowspan="1" colspan="1">0.83</td><td align="left" valign="top" rowspan="1" colspan="1">14.02</td><td align="left" valign="top" rowspan="1" colspan="1">1.07</td><td align="left" valign="top" rowspan="1" colspan="1">4.70</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x13</td><td align="left" valign="top" rowspan="1" colspan="1">0.80</td><td align="left" valign="top" rowspan="1" colspan="1">13.51</td><td align="left" valign="top" rowspan="1" colspan="1">0.97</td><td align="left" valign="top" rowspan="1" colspan="1">4.24</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x12.n</td><td align="left" valign="top" rowspan="1" colspan="1">0.70</td><td align="left" valign="top" rowspan="1" colspan="1">11.38</td><td align="left" valign="top" rowspan="1" colspan="1">0.81</td><td align="left" valign="top" rowspan="1" colspan="1">3.01</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x1.n</td><td align="left" valign="top" rowspan="1" colspan="1">0.69</td><td align="left" valign="top" rowspan="1" colspan="1">13.67</td><td align="left" valign="top" rowspan="1" colspan="1">0.82</td><td align="left" valign="top" rowspan="1" colspan="1">4.06</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Model.x12.r</td><td align="left" valign="top" rowspan="1" colspan="1">0.73</td><td align="left" valign="top" rowspan="1" colspan="1">11.37</td><td align="left" valign="top" rowspan="1" colspan="1">0.84</td><td align="left" valign="top" rowspan="1" colspan="1">3.04</td></tr><tr><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">Model.x1.r</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">0.71</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">13.44</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">0.84</td><td align="left" valign="top" style="border-bottom: solid 1px" rowspan="1" colspan="1">3.98</td></tr></tbody></table><table-wrap-foot><fn id="TFN7"><label>1</label><p id="P84">Original panel-weighted denotes the RANDS 3 estimate using the original panel weights without PS adjustment; unweighted denotes the RANDS 3 estimate using weight = 1 without PS adjustment; model.all: the full propensity model with all main and pairwise interaction terms; Model.x13: the propensity model including selected terms of the confounders and selection predictors; Model.x12.n: propensity model including terms of the confounders and outcome predictors selected using the National Health Interview Survey (NHIS); Model.x12.r: propensity model including terms of the confounders and outcome predictors selected using the Research and Development Survey (RANDS). Panel weights indicates that the RANDS 3 original panel weights were used as the base weight for the PS adjustment. No weights indicates that the RANDS 3 original panel weights were not included in the PS adjustment.</p></fn><fn id="TFN8"><label>2</label><p id="P85"><inline-formula><mml:math id="M35" display="inline"><mml:mrow><mml:mi>C</mml:mi><mml:mi>V</mml:mi><mml:mo>=</mml:mo><mml:mfrac><mml:mrow><mml:mi>s</mml:mi><mml:mi>d</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>K</mml:mi><mml:mi>W</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow><mml:mrow><mml:mi>m</mml:mi><mml:mi>e</mml:mi><mml:mi>a</mml:mi><mml:mi>n</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>K</mml:mi><mml:mi>W</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:mrow></mml:mfrac></mml:mrow></mml:math></inline-formula>, for standard deviation <italic toggle="yes">sd</italic></p></fn><fn id="TFN9"><label>3</label><p id="P86">
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</inline-formula>
</p></fn><fn id="TFN10"><label>4</label><p id="P87">se=standard error of estimated mean</p></fn><fn id="TFN11"><label>5</label><p id="P88">
<inline-formula>
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</p></fn></table-wrap-foot></table-wrap></floats-group></article>