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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="1.3" xml:lang="en" article-type="research-article"><?properties manuscript?><processing-meta base-tagset="archiving" mathml-version="3.0" table-model="xhtml" tagset-family="jats"><restricted-by>pmc</restricted-by></processing-meta><front><journal-meta><journal-id journal-id-type="nlm-journal-id">101573920</journal-id><journal-id journal-id-type="pubmed-jr-id">39705</journal-id><journal-id journal-id-type="nlm-ta">J Acad Nutr Diet</journal-id><journal-id journal-id-type="iso-abbrev">J Acad Nutr Diet</journal-id><journal-title-group><journal-title>Journal of the Academy of Nutrition and Dietetics</journal-title></journal-title-group><issn pub-type="ppub">2212-2672</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24742901</article-id><article-id pub-id-type="pmc">9237821</article-id><article-id pub-id-type="doi">10.1016/j.jand.2014.02.015</article-id><article-id pub-id-type="manuscript">HHSPA1812769</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Imbalance of Sodium and Potassium Intake: Implications for Dietetic Practice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Levings</surname><given-names>Jessica Lee</given-names></name><degrees>MS, RD</degrees><role>federal contractor/policy analyst</role></contrib><contrib contrib-type="author"><name><surname>Gunn</surname><given-names>Janelle Peralez</given-names></name><degrees>MPH, RD</degrees><role>public health analyst</role></contrib><aff id="A1">Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.</aff></contrib-group><pub-date pub-type="nihms-submitted"><day>24</day><month>6</month><year>2022</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>16</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>6</month><year>2022</year></pub-date><volume>114</volume><issue>6</issue><fpage>838</fpage><lpage>841</lpage></article-meta></front><body><p id="P1">Americans are consuming too much sodium and too little potassium. Decreasing sodium intake and increasing potassium intake can reduce the risk of high blood pressure, heart disease, and stroke, and can help control blood pressure. Registered dietitians (RD&#x02019;s) may play a role in preventing disease by counseling clients about the importance of reducing sodium intake and increasing potassium intake. This paper discusses the impact of sodium and potassium intake on health and explains the role of the registered dietitian nutritionist (RDN) when counseling clients about reducing sodium intake and increasing potassium intake.</p><sec id="S1"><title>AMERICAN INTAKE OF SODIUM AND POTASSIUM</title><p id="P2">Currently, about 90% of Americans consume excess sodium<sup><xref rid="R1" ref-type="bibr">1</xref></sup> and virtually everyone consumes inadequate potassium.<sup><xref rid="R2" ref-type="bibr">2</xref></sup> Randomized Control Trials and epidemiologic studies have demonstrated that higher sodium intake and lower potassium intake are modifiable risk factors for elevated blood pressure and hypertension,<sup><xref rid="R3" ref-type="bibr">3</xref>&#x02013;<xref rid="R11" ref-type="bibr">11</xref></sup> in addition to excess body weight, non-adherence to a Dietary Approaches to Stop Hypertension (DASH) eating plan, lack of physical activity, and excess alcohol consumption.<sup><xref rid="R12" ref-type="bibr">12</xref></sup> Non-modifiable risk factors include age and family history.<sup><xref rid="R12" ref-type="bibr">12</xref></sup> High blood pressure is a leading risk factor for heart disease and stroke which are both leading causes of death in the United States.<sup><xref rid="R13" ref-type="bibr">13</xref></sup> Reducing sodium intake and increasing potassium intake has been found to lower blood pressure. Further, higher intakes of potassium can attenuate the adverse effects of sodium on blood pressure, especially at high rather than low levels of sodium intake.<sup><xref rid="R11" ref-type="bibr">11</xref></sup> Other benefits of increased dietary potassium intake include a reduced risk of developing kidney stones and decreased bone loss.<sup><xref rid="R14" ref-type="bibr">14</xref></sup></p><p id="P3">About 90% of sodium added to processed foods is in the form of sodium chloride (salt).<sup><xref rid="R11" ref-type="bibr">11</xref></sup> Potassium is added to processed foods and supplements as potassium chloride. Potassium is also found inherently in foods as potassium citrate and to a lesser extent as potassium phosphate. Unlike potassium chloride, inherent forms of potassium favorably affect acid base balance as bicarbonate precursors.<sup><xref rid="R14" ref-type="bibr">14</xref></sup> While clinical trials indicate that potassium chloride intake can reduce blood pressure,<sup><xref rid="R15" ref-type="bibr">15</xref>&#x02013;<xref rid="R17" ref-type="bibr">17</xref></sup> observational trials indicate that inherent sources of potassium (mainly from sodium bicarbonate) may also prevent bone loss and cardiovascular disease (CVD).<sup><xref rid="R11" ref-type="bibr">11</xref></sup></p><sec id="S2"><title>Recommended Intake</title><p id="P4">The <italic toggle="yes">2010 Dietary Guidelines for Americans</italic> recommend Americans age 2 years and older reduce daily sodium intake to less than 2,300 mg and further reduce intake to 1,500 mg among persons who are 51 and older and those of any age who are African American or have hypertension, diabetes, or chronic kidney disease.<sup><xref rid="R18" ref-type="bibr">18</xref></sup> Average sodium intake for Americans ages two and older is currently much higher; about 3,400 mg per day excluding salt added at the table.<sup><xref rid="R19" ref-type="bibr">19</xref></sup> Recent research found that 79% of children aged 1&#x02013;3 years and 87% aged 4&#x02013;5 years also consume too much sodium, with an average intake of 2,504 mg per day for the older group. According to the study, black children aged 1&#x02013;5 years consume more sodium than children in any other racial or ethnic group.<sup><xref rid="R20" ref-type="bibr">20</xref></sup> The Institute of Medicine recommends that Americans age 14 and older consume 4,700 mg of potassium daily,<sup><xref rid="R11" ref-type="bibr">11</xref></sup> however current intake by all age groups is considerably lower; approximately 2,600 mg per day.<sup><xref rid="R19" ref-type="bibr">19</xref></sup> Among children, aged 1&#x02013;5, less than 10% are consuming enough potassium each day.<sup><xref rid="R20" ref-type="bibr">20</xref></sup> Similar to sodium, blacks and people with hypertension are more responsive to variations in potassium intake compared to their nonblack and non-hypertensive counterparts.<sup><xref rid="R11" ref-type="bibr">11</xref></sup></p></sec><sec id="S3"><title>Food Sources</title><p id="P5">While both sodium and potassium are naturally present in a variety of foods, more than 75% of sodium intake is from sodium added to processed foods.<sup><xref rid="R21" ref-type="bibr">21</xref></sup> Only10 food categories: bread and rolls, cold cuts/cured meats, pizza, fresh and processed poultry, soups, sandwiches (such as cheeseburgers), cheese, pasta mixed dishes (eg, spaghetti with meat sauce), meat mixed dishes (eg, meat loaf with tomato sauce), and savory snacks (eg, chips and pretzels), contribute nearly 44% of sodium intake.<sup><xref rid="R22" ref-type="bibr">22</xref></sup> Natural sources of potassium are most notably found in vegetables, fruits, and milk and milk products. However, in 2010, the top five food category contributors to potassium were reduced fat (2% and 1%) milk, coffee, chicken and chicken mixed dishes, beef and beef mixed dishes, and 100% orange/grapefruit juice.<sup><xref rid="R2" ref-type="bibr">2</xref></sup></p></sec><sec id="S4"><title>The Sodium-Potassium Ratio</title><p id="P6">Emerging research indicates that the ratio of sodium to potassium intake is a greater risk factor for hypertension and CVD than either electrolyte alone;<sup><xref rid="R10" ref-type="bibr">10</xref>,<xref rid="R23" ref-type="bibr">23</xref>&#x02013;<xref rid="R26" ref-type="bibr">26</xref></sup> however the ideal sodium to potassium ratio has not yet been defined. A recent analysis by Yang and colleagues<sup><xref rid="R27" ref-type="bibr">27</xref></sup> found that a higher ratio of sodium to potassium is associated with significantly increased risk of CVD and all-cause mortality. The average ratio of sodium to potassium for adults aged &#x02265;20 years has been found to be 1.41; the ratio of sodium to potassium is also significantly associated with systolic blood pressure.<sup><xref rid="R28" ref-type="bibr">28</xref></sup> According to the Institute of Medicine, the median ratio of sodium to potassium under 1 year of age is less than one, rises throughout childhood and adulthood, and then drops slightly in middle- and older-aged adults.<sup><xref rid="R14" ref-type="bibr">14</xref></sup> The steady rise in the ratio of sodium to potassium starting at an early age reflects an increase in sodium intake and decrease in potassium intake resulting from a Western diet heavily reliant on processed foods high in added sodium and low in added potassium.<sup><xref rid="R14" ref-type="bibr">14</xref></sup></p></sec></sec><sec id="S5"><title>IMPLICATIONS FOR DIETETICS PRACTICE</title><p id="P7">While sodium is a required nutrient to be listed on the Nutrition Facts label, labeling of potassium is voluntary.<sup><xref rid="R29" ref-type="bibr">29</xref></sup> Further, many food sources of potassium such as fresh fruits and vegetables are not required to bear any nutrition label. Packaged foods that meet nutrient criteria for &#x0201c;low sodium&#x0201d; and are considered a good source of potassium can bear the health claim: &#x0201c;Diets containing foods that are good sources of potassium and low in sodium may reduce the risk of high blood pressure and stroke.&#x0201d;<sup><xref rid="R30" ref-type="bibr">30</xref></sup> Foods that bear this claim are required to list potassium content on the food label. Encouraging clients to consume a greater variety of foods containing inherent sources of potassium, such as bananas, potatoes and sweet potatoes, low- and no-fat yogurt, dried apricots, spinach, and dried or no salt added/low sodium canned beans (other than green beans) can assist in decreasing sodium intake while increasing intake of natural sources of potassium.</p><p id="P8">Sodium content can vary significantly across different brands of the same product. For example, chicken noodle soup can vary in sodium by as much as 840 mg per serving.<sup><xref rid="R31" ref-type="bibr">31</xref></sup> Counseling patients on reading nutrition labels and choosing foods lower in sodium, as well as seeking out foods labeled &#x0201c;low sodium&#x0201d;, &#x0201c;no salt added&#x0201d;, or that bear the health claim for sodium and potassium can help patients reduce sodium intake. In addition, research has found that consuming a diet consistent with the DASH diet can help lower blood pressure while providing nutrient adequacy for sodium, potassium, and other nutrients. Studies have found that daily DASH diets containing 2,300 mg of sodium can lower blood pressure and DASH diets meeting 1,500 mg of sodium can further reduce blood pressure.<sup><xref rid="R32" ref-type="bibr">32</xref></sup> However, adults with self reported diabetes and hypertension have been found to have higher sodium intake (153% of DASH target vs. 146.6%) compared to those without either condition.<sup><xref rid="R33" ref-type="bibr">33</xref></sup> Ethnicity also impacts adherence to a DASH diet, with research indicating that blacks are less adherent to the DASH diet compared with whites.<sup><xref rid="R34" ref-type="bibr">34</xref></sup></p><p id="P9">Potassium chloride is increasingly used as a salt substitute or as a component or ingredient of a &#x0201c;lite salt&#x0201d;; efforts to reduce sodium intake may increase the reliance on potassium chloride as a salt substitute in the food supply.<sup><xref rid="R35" ref-type="bibr">35</xref></sup> Although potassium intake recommendations encourage increased potassium intake, these recommendations are made for the generally healthy population. Persons with medical conditions such as diabetes, chronic kidney disease, end-stage renal disease, severe heart failure, and adrenal insufficiency, individuals with impaired urinary potassium excretion, and individuals taking medications that result in an increase in serum potassium, such as angiotensin-converting enzyme inhibitors and potassium-sparing diuretics may not benefit from increased potassium intake.2 RDNs can assist patients and clients in determining if a potassium chloride-based salt substitute is right for them based on current medication use and disease history.</p><p id="P10">While the current food supply can cause difficulty in meeting sodium intake recommendations, gradual reductions of sodium in the food supply over time will make this more feasible, while allowing greater choice for consumers. According to recent research, approximately six in 10 Americans regularly purchase or would purchase reduced/lower sodium foods;<sup><xref rid="R36" ref-type="bibr">36</xref>,<xref rid="R37" ref-type="bibr">37</xref></sup> however, the majority report limiting added salt to food as their primary means of reducing sodium intake. RDNs can help bridge this knowledge gap through counseling patients and clients on the major sources of sodium (processed food), stressing the importance of comparing food labels and choosing foods lower in sodium as a means to reduce intake, and offering strategies to adhere to the DASH eating plan. RDNs can assist patients with understanding and overcoming adherence barriers to the DASH eating plan, and assist other health professionals by communicating successful strategies their patients have used to overcome adherence barriers.</p><p id="P11">Although blood pressure is more greatly affected by a joint decrease in sodium and increase in potassium, this combination is difficult given the current food supply. While consumers can choose to consume more potassium-rich foods, the amount of sodium currently in the food supply makes sodium reduction more challenging. Future research could assess the ratio of sodium to potassium given the impact on blood pressure. Patient education by RDNs supporting decreased sodium intake and increased potassium intake would also be beneficial, especially for black and hypertensive populations.</p></sec></body><back><ref-list><title>References</title><ref id="R1"><label>1.</label><mixed-citation publication-type="journal"><collab>Centers for Disease Control and Prevention</collab>. <article-title>Usual Sodium Intakes Compared with Current Dietary Guidelines &#x02013; United States, 2005 &#x02013; 2008</article-title>. <source>MMWR</source> (<year>2011</year>); <volume>60</volume>(<issue>41</issue>):<fpage>1413</fpage>&#x02013;<lpage>1417</lpage>.<pub-id pub-id-type="pmid">22012113</pub-id></mixed-citation></ref><ref id="R2"><label>2.</label><mixed-citation publication-type="webpage"><name><surname>Department of Health</surname><given-names>US</given-names></name> and <name><surname>Human Services</surname><given-names>US</given-names></name>
<article-title>Department of Agriculture. Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010</article-title>. <source>Part D. Section 6: Sodium, Potassium, and Water</source>. <comment>Available at <ext-link xlink:href="http://www.cnpp.usda.gov/Publications/DietaryGuidelines/2010/DGAC/Report/D-6-SodiumPotassiumWater.pdf" ext-link-type="uri">www.cnpp.usda.gov/Publications/DietaryGuidelines/2010/DGAC/Report/D-6-SodiumPotassiumWater.pdf</ext-link></comment>.</mixed-citation></ref><ref id="R3"><label>3.</label><mixed-citation publication-type="journal"><collab>Intersalt Cooperative Research Group</collab>. <article-title>Intersalt: an international study of electrolyte excretion and blood pressure: results for 24 hour urinary sodium and potassium excretion</article-title>. <source>BMJ</source>. <year>1988</year>;<volume>297</volume>(<issue>6644</issue>):<fpage>319</fpage>&#x02013;<lpage>328</lpage>.<pub-id pub-id-type="pmid">3416162</pub-id></mixed-citation></ref><ref id="R4"><label>4.</label><mixed-citation publication-type="journal"><name><surname>Strazzullo</surname><given-names>P</given-names></name>, <name><surname>D&#x02019;Elia</surname><given-names>L</given-names></name>, <name><surname>Kandala</surname><given-names>NB</given-names></name>, <name><surname>Cappuccio</surname><given-names>FP</given-names></name>. <article-title>Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies</article-title>. <source>BMJ</source>. <year>2009</year>;<volume>339</volume>:<fpage>b4567</fpage>.<pub-id pub-id-type="pmid">19934192</pub-id></mixed-citation></ref><ref id="R5"><label>5.</label><mixed-citation publication-type="journal"><name><surname>Sica</surname><given-names>DA</given-names></name>, <name><surname>Struthers</surname><given-names>AD</given-names></name>, <name><surname>Cushman</surname><given-names>WC</given-names></name>, <name><surname>Wood</surname><given-names>M</given-names></name>, <name><surname>Banas</surname><given-names>JS</given-names><suffix>Jr</suffix></name>, <name><surname>Epstein</surname><given-names>M</given-names></name>. <article-title>Importance of potassium in cardiovascular disease</article-title>. <source>J Clin Hypertens (Greenwich)</source>. <year>2002</year>;<volume>4</volume>(<issue>3</issue>):<fpage>198</fpage>&#x02013;<lpage>206</lpage>.<pub-id pub-id-type="pmid">12045369</pub-id></mixed-citation></ref><ref id="R6"><label>6.</label><mixed-citation publication-type="journal"><name><surname>Whelton</surname><given-names>PK</given-names></name>, <name><surname>He</surname><given-names>J</given-names></name>, <name><surname>Cutler</surname><given-names>JA</given-names></name>, <etal/>
<article-title>Effects of oral potassium on blood pressure: metaanalysis of randomized controlled clinical trials</article-title>. <source>JAMA</source>. <year>1997</year>;<volume>277</volume>(<issue>20</issue>):<fpage>1624</fpage>&#x02013;<lpage>1632</lpage>.<pub-id pub-id-type="pmid">9168293</pub-id></mixed-citation></ref><ref id="R7"><label>7.</label><mixed-citation publication-type="journal"><collab>Trials of Hypertension Prevention Collaborative Research Group</collab>. <article-title>Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure: the Trials of Hypertension Prevention, phase II</article-title>. <source>Arch Intern Med</source>. <year>1997</year>;<volume>157</volume>(<issue>6</issue>):<fpage>657</fpage>&#x02013;<lpage>667</lpage>.<pub-id pub-id-type="pmid">9080920</pub-id></mixed-citation></ref><ref id="R8"><label>8.</label><mixed-citation publication-type="journal"><name><surname>Cook</surname><given-names>NR</given-names></name>, <name><surname>Cutler</surname><given-names>JA</given-names></name>, <name><surname>Obarzanek</surname><given-names>E</given-names></name>, <etal/>
<article-title>Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)</article-title>. <source>BMJ</source>. <year>2007</year>;<volume>334</volume>(<issue>7599</issue>):<fpage>885</fpage>&#x02013;<lpage>888</lpage>.<pub-id pub-id-type="pmid">17449506</pub-id></mixed-citation></ref><ref id="R9"><label>9.</label><mixed-citation publication-type="journal"><name><surname>Iso</surname><given-names>H</given-names></name>, <name><surname>Stampfer</surname><given-names>MJ</given-names></name>, <name><surname>Manson</surname><given-names>JE</given-names></name>, <etal/>
<article-title>Prospective study of calcium, potassium, and magnesium intake and risk of stroke in women</article-title>. <source>Stroke</source> (<year>1999</year>) <volume>30</volume>(<issue>9</issue>):<fpage>1772</fpage>&#x02013;<lpage>1779</lpage>.<pub-id pub-id-type="pmid">10471422</pub-id></mixed-citation></ref><ref id="R10"><label>10.</label><mixed-citation publication-type="journal"><name><surname>Cook</surname><given-names>NR</given-names></name>, <name><surname>Obarzanek</surname><given-names>E</given-names></name>, <name><surname>Cutler</surname><given-names>JA</given-names></name>, <etal/>; <article-title>Trials of Hypertension Prevention Collaborative Research Group. Joint effects of sodium and potassium intake on subsequent cardiovascular disease: the Trials of Hypertension Prevention follow-up study</article-title>. <source>Arch Intern Med</source>. <year>2009</year>;<volume>169</volume>(<issue>1</issue>):<fpage>32</fpage>&#x02013;<lpage>40</lpage>.<pub-id pub-id-type="pmid">19139321</pub-id></mixed-citation></ref><ref id="R11"><label>11.</label><mixed-citation publication-type="book"><collab>IOM (Institute of Medicine)</collab>. <year>2005</year>. <source>Dietary Reference Intakes for water, potassium, sodium, chloride, and sulfate</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>The National Academies Press</publisher-name>. Pp. <fpage>269</fpage>&#x02013;<lpage>423</lpage>.</mixed-citation></ref><ref id="R12"><label>12.</label><mixed-citation publication-type="webpage"><collab>U.S. Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, National High Blood Pressure Education Program</collab>. <article-title>The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (2003)</article-title>. <source>NIH Publication No. 03 &#x02013; 5233</source>. <comment>Available</comment>: <comment><ext-link xlink:href="http://www.nhlbi.nih.gov/guidelines/hypertension/express.pdf" ext-link-type="uri">http://www.nhlbi.nih.gov/guidelines/hypertension/express.pdf</ext-link></comment>.</mixed-citation></ref><ref id="R13"><label>13.</label><mixed-citation publication-type="journal"><name><surname>Minino</surname><given-names>AM</given-names></name>, <name><surname>Xu</surname><given-names>J</given-names></name>, <name><surname>Kochanek</surname><given-names>KD</given-names></name>, <name><surname>Murphy</surname><given-names>SL</given-names></name>. <article-title>Deaths: final data for 2008</article-title>. <source>Natl Vital Stat Rep</source>. <year>2011</year>;<volume>59</volume>(<issue>10</issue>). <comment>Available at <ext-link xlink:href="http://www.cdc.gov/nchs/data/nvsr/nvsr59/nvsr59_10.pdf" ext-link-type="uri">http://www.cdc.gov/nchs/data/nvsr/nvsr59/nvsr59_10.pdf</ext-link></comment>.</mixed-citation></ref><ref id="R14"><label>14.</label><mixed-citation publication-type="book"><collab>IOM (Institute of Medicine)</collab>. <year>2005</year>. <source>Dietary Reference Intakes for water, potassium, sodium, chloride, and sulfate</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>The National Academies Press</publisher-name>. Pp. <fpage>186</fpage>&#x02013;<lpage>268</lpage>.</mixed-citation></ref><ref id="R15"><label>15.</label><mixed-citation publication-type="journal"><name><surname>Geleijnse</surname><given-names>JM</given-names></name>, <name><surname>Kok</surname><given-names>FJ</given-names></name>, <name><surname>Grobbee</surname><given-names>DE</given-names></name>. <year>2003</year>. <article-title>Blood pressure response to changes in sodium and potassium intake: A metaregression analysis of randomised trials</article-title>. <source>J Hum Hypertens</source>
<volume>17</volume>:<fpage>471</fpage>&#x02013;<lpage>480</lpage>.<pub-id pub-id-type="pmid">12821954</pub-id></mixed-citation></ref><ref id="R16"><label>16.</label><mixed-citation publication-type="journal"><name><surname>Whelton</surname><given-names>PK</given-names></name>, <name><surname>He</surname><given-names>J</given-names></name>, <name><surname>Cutler</surname><given-names>JA</given-names></name>, <name><surname>Brancati</surname><given-names>FL</given-names></name>, <name><surname>Appel</surname><given-names>LJ</given-names></name>, <name><surname>Follmann</surname><given-names>D</given-names></name>, <name><surname>Klag</surname><given-names>MJ</given-names></name>. <year>1997</year>. <article-title>Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials</article-title>. <source>J Am Med Assoc</source>
<volume>277</volume>:<fpage>1624</fpage>&#x02013;<lpage>1632</lpage>.</mixed-citation></ref><ref id="R17"><label>17.</label><mixed-citation publication-type="journal"><name><surname>Cappuccio</surname><given-names>FP</given-names></name>, <name><surname>MacGregor</surname><given-names>GA</given-names></name>. <year>1991</year>. <article-title>Does potassium supplementation lower blood pressure? A meta-analysis of published trials</article-title>. <source>J Hypertens</source>
<volume>9</volume>:<fpage>465</fpage>&#x02013;<lpage>473</lpage>.<pub-id pub-id-type="pmid">1649867</pub-id></mixed-citation></ref><ref id="R18"><label>18.</label><mixed-citation publication-type="book"><collab>US Department of Health and Human Services, US Department of Agriculture</collab>. <source>Dietary guidelines for Americans, 2010</source>. <edition>7th ed.</edition>
<publisher-loc>Washington DC</publisher-loc>: <publisher-name>US Department of Health and Human Services, US Department of Agriculture</publisher-name>; <year>2011</year>. <comment>Available at <ext-link xlink:href="http://health.gov/dietaryguidelines/2010.asp" ext-link-type="uri">http://health.gov/dietaryguidelines/2010.asp</ext-link></comment>. <date-in-citation>Accessed October 18, 2011</date-in-citation>.</mixed-citation></ref><ref id="R19"><label>19.</label><mixed-citation publication-type="webpage"><collab>US Department of Agriculture, Agriculture Research Service</collab>. <source>What We Eat in America 2009 &#x02013; 2010</source>. <comment>Available at <ext-link xlink:href="http://www.ars.usda.gov/Services/docs.htm?docid=18349" ext-link-type="uri">http://www.ars.usda.gov/Services/docs.htm?docid=18349</ext-link></comment>.</mixed-citation></ref><ref id="R20"><label>20.</label><mixed-citation publication-type="journal"><name><surname>Tian</surname><given-names>N</given-names></name>, <name><surname>Zhang</surname><given-names>Z</given-names></name>, <name><surname>Loustalot</surname><given-names>F</given-names></name>, <name><surname>Yang</surname><given-names>Q</given-names></name>, <name><surname>Cogswell</surname><given-names>ME</given-names></name>. <article-title>Sodium and potassium intake among infants and preschool children, United States, 2001&#x02013;2008</article-title>. <source>Am J Clin Nutr</source>
<year>2013</year>;<volume>98</volume>(<issue>4</issue>):<fpage>1113</fpage>&#x02013;<lpage>1122</lpage>.<pub-id pub-id-type="pmid">23966425</pub-id></mixed-citation></ref><ref id="R21"><label>21.</label><mixed-citation publication-type="journal"><name><surname>Mattes</surname><given-names>RD</given-names></name>, <name><surname>Donnelly</surname><given-names>D</given-names></name>. <article-title>Relative contributions of dietary sodium sources</article-title>. <source>J Am Coll Nutr</source>
<year>1991</year>;<volume>10</volume>:<fpage>383</fpage>&#x02013;<lpage>93</lpage>.<pub-id pub-id-type="pmid">1910064</pub-id></mixed-citation></ref><ref id="R22"><label>22.</label><mixed-citation publication-type="journal"><collab>Centers for Disease Control and Prevention</collab>. <article-title>Vital Signs: Food Categories Contributing the Most to Sodium Consumption &#x02014; United States, 2007&#x02013;2008</article-title>. <source>MMWR</source>, <year>2012</year>;<volume>61</volume>(<issue>05</issue>):<fpage>1</fpage>&#x02013;<lpage>7</lpage>.</mixed-citation></ref><ref id="R23"><label>23.</label><mixed-citation publication-type="journal"><name><surname>Geleijnse</surname><given-names>JM</given-names></name>, <name><surname>Witteman</surname><given-names>JCM</given-names></name>, <name><surname>Stijnen</surname><given-names>T</given-names></name>, <name><surname>Kloos</surname><given-names>MW</given-names></name>, <name><surname>Hofman</surname><given-names>A</given-names></name>, <name><surname>Grobbee</surname><given-names>DE</given-names></name>. <article-title>Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study</article-title>. <source>Eur J Epidemiol</source>. <year>2007</year>;<volume>22</volume>(<issue>11</issue>):<fpage>763</fpage>&#x02013;<lpage>770</lpage>.<pub-id pub-id-type="pmid">17902026</pub-id></mixed-citation></ref><ref id="R24"><label>24.</label><mixed-citation publication-type="journal"><name><surname>Adrogu&#x000e9;</surname><given-names>HJ</given-names></name>, <name><surname>Madias</surname><given-names>NE</given-names></name>. <article-title>Shared primacy of sodium and potassium on cardiovascular risk</article-title>. <source>Am J Kidney Dis</source>. <year>2009</year>;<volume>54</volume>(<issue>4</issue>):<fpage>598</fpage>&#x02013;<lpage>601</lpage>.<pub-id pub-id-type="pmid">19577349</pub-id></mixed-citation></ref><ref id="R25"><label>25.</label><mixed-citation publication-type="journal"><name><surname>Adrogu&#x000e9;</surname><given-names>HJ</given-names></name>, <name><surname>Madias</surname><given-names>NE</given-names></name>. <article-title>Sodium and potassium in the pathogenesis of hypertension</article-title>. <source>N Engl J Med</source>. <year>2007</year>;<volume>356</volume>(<issue>19</issue>):<fpage>1966</fpage>&#x02013;<lpage>1978</lpage>.<pub-id pub-id-type="pmid">17494929</pub-id></mixed-citation></ref><ref id="R26"><label>26.</label><mixed-citation publication-type="journal"><name><surname>Umesawa</surname><given-names>M</given-names></name>, <name><surname>Iso</surname><given-names>H</given-names></name>, <name><surname>Date</surname><given-names>C</given-names></name>, <etal/>; <collab>JACC Study Group</collab>. <article-title>Relations between dietary sodium and potassium intakes and mortality from cardiovascular disease: the Japan Collaborative Cohort Study for Evaluation of Cancer Risks</article-title>. <source>Am J Clin Nutr</source>. <year>2008</year>;<volume>88</volume>(<issue>1</issue>):<fpage>195</fpage>&#x02013;<lpage>202</lpage>.<pub-id pub-id-type="pmid">18614741</pub-id></mixed-citation></ref><ref id="R27"><label>27.</label><mixed-citation publication-type="journal"><name><surname>Yang</surname><given-names>Q</given-names></name>, <name><surname>Zhang</surname><given-names>Z</given-names></name>, <name><surname>Kuklina</surname><given-names>EV</given-names></name>, <name><surname>Fang</surname><given-names>J</given-names></name>, <name><surname>Ayala</surname><given-names>C</given-names></name>, <name><surname>Hong</surname><given-names>Y</given-names></name>, <name><surname>Loustalot</surname><given-names>F</given-names></name>, <name><surname>Dai</surname><given-names>S</given-names></name>, <name><surname>Gunn</surname><given-names>JP</given-names></name>, <name><surname>Tian</surname><given-names>N</given-names></name>, <name><surname>Cogswell</surname><given-names>ME</given-names></name>, <name><surname>Merritt</surname><given-names>R</given-names></name>. <article-title>Sodium intake and blood pressure among US children and adolescents, by weight status</article-title>. <source>Pediatrics</source>
<year>2012</year>; <volume>130</volume>(<issue>4</issue>): <fpage>611</fpage>&#x02013;<lpage>619</lpage>.<pub-id pub-id-type="pmid">22987869</pub-id></mixed-citation></ref><ref id="R28"><label>28.</label><mixed-citation publication-type="journal"><name><surname>Zhang</surname><given-names>Z</given-names></name>, <name><surname>Cogswell</surname><given-names>ME</given-names></name>, <name><surname>Gillespie</surname><given-names>C</given-names></name>, <name><surname>Fang</surname><given-names>J</given-names></name>, <name><surname>Loustalot</surname><given-names>F</given-names></name>, <etal/> (<year>2013</year>) <article-title>Association between Usual Sodium and Potassium Intake and Blood Pressure and Hypertension among U.S. Adults: NHANES 2005&#x02013;2010</article-title>. <source>PLoS ONE</source>
<volume>8</volume>(<issue>10</issue>): <fpage>e75289</fpage>. doi:<pub-id pub-id-type="doi">10.1371/journal.pone.0075289</pub-id><pub-id pub-id-type="pmid">24130700</pub-id></mixed-citation></ref><ref id="R29"><label>29.</label><mixed-citation publication-type="journal"><collab>Office of the Federal Register</collab>. <article-title>Food Labeling; Mandatory Status of Nutrition Labeling and Nutrient Content Revision</article-title>. <source>Final Rule. 58 CFR 2079</source> (<year>1993</year>).</mixed-citation></ref><ref id="R30"><label>30.</label><mixed-citation publication-type="confproc"><source>Public Law105&#x02013;115</source>, <conf-name>105th Congress</conf-name>.</mixed-citation></ref><ref id="R31"><label>31.</label><mixed-citation publication-type="webpage"><collab>Centers for Disease Control and Prevention</collab>. <source>Vital Signs: Where&#x02019;s the Sodium?</source>
<comment>Available</comment>: <comment><ext-link xlink:href="http://www.cdc.gov/vitalsigns/Sodium/index.html" ext-link-type="uri">http://www.cdc.gov/vitalsigns/Sodium/index.html</ext-link></comment>.</mixed-citation></ref><ref id="R32"><label>32.</label><mixed-citation publication-type="journal"><name><surname>Morton</surname><given-names>S</given-names></name>, <name><surname>Saydah</surname><given-names>S</given-names></name>, <name><surname>Cleary</surname><given-names>S</given-names></name>, <article-title>Consistency with the Dietary Approaches to Stop Hypertension Diet among Adults with Diabetes</article-title>. <source>J Acad Nutr Diet</source>
<year>2012</year>; <volume>112</volume>(<issue>11</issue>):<fpage>1798</fpage>&#x02013;<lpage>1805</lpage>.<pub-id pub-id-type="pmid">23102178</pub-id></mixed-citation></ref><ref id="R33"><label>33.</label><mixed-citation publication-type="journal"><name><surname>Epstein</surname><given-names>DE</given-names></name>, <name><surname>Sherwood</surname><given-names>A</given-names></name>, <name><surname>Smith</surname><given-names>PJ</given-names></name>, <name><surname>Craighead</surname><given-names>L</given-names></name>, <name><surname>Caccia</surname><given-names>C</given-names></name>, <name><surname>Lin</surname><given-names>PH</given-names></name>, <etal/>
<article-title>Determinants and consequences of adherence to the dietary approaches to stop hypertension diet in African-American and white adults with high blood pressure: results from the ENCORE trial</article-title>. <source>J Acad Nutr Diet</source>. <year>2012</year>;<volume>112</volume>(<issue>11</issue>):<fpage>1763</fpage>&#x02013;<lpage>73</lpage>.<pub-id pub-id-type="pmid">23000025</pub-id></mixed-citation></ref><ref id="R34"><label>34.</label><mixed-citation publication-type="webpage"><collab>National Heart Lung and Blood Institute, National Institutes of Health</collab>. <source>Your Guide to Lowering Your Blood Pressure with DASH</source>. <date-in-citation>Accessed May 14, 2012</date-in-citation>. Available at: <comment><ext-link xlink:href="http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/introduction.html" ext-link-type="uri">http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/introduction.html</ext-link></comment>.</mixed-citation></ref><ref id="R35"><label>35.</label><mixed-citation publication-type="book"><collab>Institute of Medicine</collab>. <source>Strategies to reduce sodium intake in the United States</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>The National Academies Press</publisher-name>; <year>2010</year>.</mixed-citation></ref><ref id="R36"><label>36.</label><mixed-citation publication-type="webpage"><collab>International Food Information Council</collab>. <source>2011 Food and Health Survey</source>. <date-in-citation>Accessed March 13, 2012</date-in-citation>. Available at: <comment><ext-link xlink:href="http://www.foodinsight.org/Content/3840/2011%20IFIC%20FDTN%20Food%20and%20Health%20Survey.pdf" ext-link-type="uri">http://www.foodinsight.org/Content/3840/2011%20IFIC%20FDTN%20Food%20and%20Health%20Survey.pdf</ext-link></comment>.</mixed-citation></ref><ref id="R37"><label>37.</label><mixed-citation publication-type="webpage"><collab>Mintel Oxygen Report</collab>. <source>Attitudes Toward Sodium - US</source>. (<year>2012</year>) <comment>Available at</comment>: <comment><ext-link xlink:href="http://www.mintel.com/press-centre/press-releases/849/fifteen-percent-of-dieters-are-concerned-about-salt-intake" ext-link-type="uri">http://www.mintel.com/press-centre/press-releases/849/fifteen-percent-of-dieters-are-concerned-about-salt-intake</ext-link></comment>.</mixed-citation></ref></ref-list></back></article>