Details:

Alternative Title:
AIDS Res Treat
Personal Author:
Siberry, George K. ; Frederick, Toni ; Emmanuel, Patricia ; Paul, Mary E. ; Bohannon, Beverly ; ... More +
Siberry, George K. ; Frederick, Toni ; Emmanuel, Patricia ; Paul, Mary E. ; Bohannon, Beverly ; Wheeling, Travis ; Barton, Theresa ; Rathore, Mobeen H. ; Dominguez, Kenneth L. Less -
Description:
Background. Methicillin-resistant Staphylococcus aureus (MRSA) infection incidence has increased in healthy US children. Our objective was to evaluate MRSA incidence and correlates in HIV-infected youth. Methods. The CDC-sponsored LEGACY study is a US multicenter chart abstraction study of HIV-infected youth. We identified MRSA infections among participants with ≥1 visit during 2006. We used bivariate and multivariable analyses to compare sociodemographic and HIV clinical factors between MRSA cases and noncases. Results. Fourteen MRSA infections (1 invasive, 12 soft tissue, 1 indeterminate) occurred among 1,813 subjects (11.1 infections/1,000 patient-years (PY), 95% CI: 11.06-11.14). Most (86%) isolates were clindamycin susceptible. Compared with noncases, MRSA cases were more likely older (17 versus 14 years), black (100% versus 69%), behaviorally HIV infected (43% versus 17%), and in Maryland (43% versus 7%) and had viral loads (VL) >1000 copies/mL (86% versus 51%) and lower mean CD4% (18% versus 27%) (all P < 0.05). In multivariate analysis, independent risk factors were Maryland care site (adjusted odds ratio (aOR) = 9.0), VL >1000 copies/mL (aOR = 5.9), and black race (aOR undefined). Conclusions. MRSA occurred at a rate of 11.1 infections/1,000 PY in HIV-infected youth but invasive disease was uncommon. Geographic location, black race, and increased VL, but not immunosuppression, were independently associated with MRSA risk.
Subject:
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Research Article

Source:
AIDS Res Treat. 2012; 2012.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:ae858ce3ad4b24661d8dbce3ba3615962d13ccba9d1904a0301d85e57d281637
File Type:

Supporting Files

• 	ART2012-627974.nxml	txt
  	license.txt	txt

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