ࡱ > bjbj x x 1 ) ) ) ) ) $ M M M P M g d M " o o o ! ! ! g g g g g g g Fj l R g ) C4 ! ! C4 C4 g ) ) o o D g OS OS OS C4 ) o ) o ` OS C4 g OS OS OS o
#J M M V OS ` g 0 g OS :m /P b :m OS OS :m ) EU ! B ' x OS u, 0 : ! ! ! g g R ! ! ! g C4 C4 C4 C4 :m ! ! ! ! ! ! ! ! ! : Supplemental Tables (for on-line supplement references for included studies are found in main text.
Supplemental Table 1a. Overview of settings of 32 studies Included in Individual Patient Data Meta-analysis of MDR-TB
First Author
(Contact Person)
ReferenceYears of Study*LocationCatchment Area
Source of MDR-TB casesType of Drug Regimen
(with second line drugs unless marked)Number of subjects with MDR-TB eligible for present meta-analysis**Avendao (Avendao) ADDIN REFMGR.CITE Avendano M20004182Multidrug-resistant tuberculosis: long term follow-up of 40 non-HIV-infected patientsJournal4182Multidrug-resistant tuberculosis: long term follow-up of 40 non-HIV-infected patientsAvendano MGoldstein RS2000tuberculosisNot in File383389Can Respir J7Can Respir J1[16]2000-2009Canada
(Toronto)HospitalReferral centreIndividualized72 Burgos (Burgos) ADDIN REFMGR.CITE Burgos M20054184Treatment of multidrug-resistant tuberculosis in San Francisco: an outpatient-based approachJournal4184Treatment of multidrug-resistant tuberculosis in San Francisco: an outpatient-based approachBurgos MGonzalez LCPaz EAGournis EPaz AKawamura LMSchecter GHopewell PCDaley CL2005treatmenttuberculosisSan FranciscoNot in File968975Clinical Infectious Diseases40Clinical Infectious Diseases1[17]1983-2000USA
(San Francisco)CityTB Section of San Francisco Department of Public HealthIndividualized45Chan (Strand) ADDIN REFMGR.CITE ADDIN EN.CITE.DATA [18,19]1984-1998USA
(Colorado)HospitalNational Jewish Medical and Research CenterIndividualized194Chiang (Enarson) ADDIN REFMGR.CITE Chiang CY20064151Outcome of pulmonary multidrug-resistant tuberculosis: a 6-yr follow-up studyJournal4151Outcome of pulmonary multidrug-resistant tuberculosis: a 6-yr follow-up studyChiang CYEnarson DAYu MCBai KJHuang RMHsu CJSuo JLin TP2006tuberculosisNot in File980985Eur Respir J28Eur Respir J1[20]1992-1996Taiwan
(Taipei)City
(network)Mycobacteriology Laboratory of the Chronic Disease Control Bureau (linked with network of public health nurses in townships & villages)Individualized125Cox (Cox) ADDIN REFMGR.CITE Cox HS20074153Multidrug-resistant tuberculosis treatment outcomes in Karakalpakstan, Uzbekistan: treatment complexity and XDR-TB among treatment failuresJournal4153Multidrug-resistant tuberculosis treatment outcomes in Karakalpakstan, Uzbekistan: treatment complexity and XDR-TB among treatment failuresCox HSStobdan KAllamuratova SSizaire VTigay ZNRusch-Gerdes SKarimovich HAKebede YMills C2007tuberculosistreatmentTreatment OutcomeNot in Filee1126PLoS2PLoS1[21]
2003-2005
Uzbekistan
Community
(multi-center)
Nukus City hospital and outpatient clinics and DOTS clinics in Chimbay districtIndividualized77
De Riemer (Garcia-Garcia) ADDIN REFMGR.CITE DeRiemer K20054186Does DOTS work in populations with drug-resistant tuberculosis?Journal4186Does DOTS work in populations with drug-resistant tuberculosis?DeRiemer KGarcia-Garcia LBodadilla-del-Valle MPalacinos-Martinez MMartinez-Gamboa ASmall PMSifuentes-Osornio JPonce-de-Leon A2005DOTworkpopulationNot in File123945Lancet365The LancetLancet1[22]1994-2009Mexico
(Veracruz)Community
(multi-center)National TB ProgramStandardized
(43 patients received first-line drugs only)47Escudero (Pena) ADDIN REFMGR.CITE Escudero E20064154Multidrug-resistant tuberculosis without HIV infection: success with individualised therapyJournal4154Multidrug-resistant tuberculosis without HIV infection: success with individualised therapyEscudero EPena JMAlvarez-Sala RVazquez JJOrtega A2006tuberculosisHIVinfectionNot in File409414Int J Tuberc Lung Dis10Int J Tuberc Lung Dis1[23]1998-2000Spain
(Madrid)HospitalUniversity HospitalIndividualized18Geerligs (van der Werf) ADDIN REFMGR.CITE Geerligs WA20004145Multidrug-resistant tuberculosis: long-term treatment outcome in the NetherlandsJournal4145Multidrug-resistant tuberculosis: long-term treatment outcome in the NetherlandsGeerligs WAvan Altena Rdelange WCMvan Soolingen Dvan der Werf TS2000tuberculosistreatmentTreatment OutcomeNot in File758764Int J Tuberc Lung Dis4Int J Tuberc Lung Dis1[24]
1987-1988, 1998-2008The Netherlands
Community
(multi-center)Two specialized referral centers for TBIndividualized43
Granich/ Banerjee (Flood) ADDIN REFMGR.CITE ADDIN EN.CITE.DATA [25,26]1994-2006 (paper goes to 2003)USA
(California)State (California)State TB Program dataIndividualized100Holtz (Van der Walt) ADDIN REFMGR.CITE Holtz TH20064157Risk factors associated with default from multidrug-resistant tuberculosis treatment, South Africa, 1999-2001Journal4157Risk factors associated with default from multidrug-resistant tuberculosis treatment, South Africa, 1999-2001Holtz THLancaster JLaserson KFWells CDThorpe LWeyer K2006RiskRisk FactorstuberculosistreatmentSouth AfricaAfricaNot in File649655Int J Tuberc Lung Dis10Int J Tuberc Lung Dis1[27]2000-2004South Africa
(All centres)Country
(multi-center)National TB ProgramStandardized2174DH Kim (Shim) ADDIN REFMGR.CITE Kim DH20084158Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosisJournal4158Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosisKim DHKim HJPark SKKong SKim YSKim THKim EKLee KMLee SSPark JSKoh WJLee CHKim JYShim TS2008treatmentTreatment OutcomesurvivalNot in File10751082Am J Respir Crit Care Med178Am J Respir Crit Care Med1[28]2000-2002South Korea
(Seoul)Country
(multi-center)National TB Hospitals, Korean National TB Association Chest Clinics & eight randomly selected university hospitalsIndividualized1288HR Kim (Yim) ADDIN REFMGR.CITE Kim HR20074159Impact of extensive drug resistance on treatment outcomes in non-HIV-infected patients with multidrug-resistant tuberculosisJournal4159Impact of extensive drug resistance on treatment outcomes in non-HIV-infected patients with multidrug-resistant tuberculosisKim HRHwang SSKim HJLee SMYoo CGKim YWHan SKShim YSYim JJ2007drug resistanceresistancetreatmentTreatment OutcometuberculosisNot in File12901295Clin.Infect.Dis45Clin.Infect.Dis1[29]1980-2007South Korea
(Seoul)HospitalUniversity-affiliated tertiary care referral hospital (Seoul National University Hospital)Individualized182Kwon (Koh) ADDIN REFMGR.CITE Kwon YS20084160Treatment outcomes for HIV-uninfected patients with multidrug-resistant and extensively drug-resistant tuberculosis Journal4160Treatment outcomes for HIV-uninfected patients with multidrug-resistant and extensively drug-resistant tuberculosis Kwon YSKim YHSuh GYChung MKim HKwon OJChoi YSKim KKim JShim YMKoh WJ2008treatmentTreatment OutcometuberculosisNot in File496502Clin.Infect.Dis47Clin.Infect.Dis1[30]1995-2005South Korea
(Seoul)HospitalUniversity-affiliated Tertiary Care Hospital (Samsung Medical Center)Individualized129Leimane/Holtz/Riekstina ADDIN REFMGR.CITE ADDIN EN.CITE.DATA [3133]2000-2004Latvia
(Stopinu Novads)ClinicNational TB Control ProgramIndividualized945Lockman (Viiklepp) ADDIN REFMGR.CITE Lockman S20014179Clinical outcomes of Estonian patients with primary multidrug-resistant versus drug-susceptible tuberculosisJournal4179Clinical outcomes of Estonian patients with primary multidrug-resistant versus drug-susceptible tuberculosisLockman SKruuner ABinkin NLevina KWang YCDanilovitsh MHoffner SETappero JW2001primaryIn File37380Clin.Infect.Dis32Clin.Infect.Dis1[34]2000-2002Estonia
(All centres)
CountryNational TB ProgramIndividualized218Masjedi (Tabarsi) ADDIN REFMGR.CITE Masjedi MR20084162Outcome of treatment of MDR-TB patients with standardised regimens, Iran, 2002-2006Journal4162Outcome of treatment of MDR-TB patients with standardised regimens, Iran, 2002-2006Masjedi MRTabarsi PChitsaz PBaghaei PMiraeidi MAmiri MVFarnia PJavanmard Pmansouri DVelayati AA2008treatmentMDR-TBNot in File750755Int J Tuberc Lung Dis12Int J Tuberc Lung Dis1[35]2002-2006IranCountry
(multi-center)National Mycobacteriological Reference LaboratoryStandardized27Migliori (Centis) ADDIN REFMGR.CITE ADDIN EN.CITE.DATA [36,37]2001-2004
ItalyCountry
(multi-centre)TB Clinical Reference Centers in ItalyIndividualized83Mitnick (Mitnick) ADDIN REFMGR.CITE ADDIN EN.CITE.DATA [38,39]1996-2002Peru
(Lima)City
(multi-centre)Peruvian National TB ProgrammeIndividualized654Munsiff/Li (Ahuja) ADDIN REFMGR.CITE Munsiff SS20064165Public-private collaboration for multidrug-resistant tuberculosis control in New York cityJournal4165Public-private collaboration for multidrug-resistant tuberculosis control in New York cityMunsiff SSAhuja SDLi JDriver CR2006tuberculosiscontrolNew YorkNot in File639648Int J Tuberc Lung Dis10Int J Tuberc Lung Dis1Li J20044161Use of therapeutic drug monitoring for multidrug-resistant tuberculosis patientsJournal4161Use of therapeutic drug monitoring for multidrug-resistant tuberculosis patientsLi JBurzynski JNLee YABerg DDriver CRRidzon RMunsiff SS2004Drug MonitoringtuberculosisNot in File17701776Chest126Chest1[40,41]1992-1997USA
(New York)City and StateLocal and State TB ProgramIndividualized671Narita (Narita) ADDIN REFMGR.CITE Narita M20014192Treatment experience of multidrug-resistant tuberculosis in Florida, 1994-1997Journal4192Treatment experience of multidrug-resistant tuberculosis in Florida, 1994-1997Narita MAlonso PLazardo MHollender EPitchenik AAshkin D2001treatmenttuberculosisFloridaIn File343348Chest120Chest1[42]1993-1997USA
(Florida)StateFlorida State TB LaboratoryIndividualized66ORiordan (Pasvol) ADDIN REFMGR.CITE O'Riordan P20084166Rapid molecular detection of rifampicin resistance facilitates early diagnosis and treatment of multidrug-resistant tuberculosis: case control studyJournal4166Rapid molecular detection of rifampicin resistance facilitates early diagnosis and treatment of multidrug-resistant tuberculosis: case control studyO'Riordan PSchwab ULogan SCooke GWilkinson RJDavidson RNBassett PWall RPasvol GFlanagan KL2008resistanceEarly DiagnosisdiagnosistreatmenttuberculosiscontrolNot in Filee3173Plos ONE3Plos ONE1[43]1982-2004UK
( London)HospitalNorthwick Park Hospital (local population, Health Care Unit at Londons Heathrow & Gatwick Airport, and tertiary referrals from other hospitals)Individualized28Palmero (Palmero) ADDIN REFMGR.CITE Palmero DJ20044193Treatment and follow-up of HIV-negative multidrug-resistant tuberculosis patients in an infectious diseases reference hospital, Buenos Aires, ArgentinaJournal4193Treatment and follow-up of HIV-negative multidrug-resistant tuberculosis patients in an infectious diseases reference hospital, Buenos Aires, ArgentinaPalmero DJAmbroggi MBrea ADe Lucas MFulgenzi AMartinez DMosca CMusella RNariello MGonzalez CAbbate E2004treatmenttuberculosisinfectiousdiseaseIn File778784Int J Tuberc Lung Dis8Int J Tuberc Lung Dis1[44]1996-1999Argentina
(Buenos Aires)HospitalNational Reference Hospital for Infectious Diseases (Hospital Muiz)Individualized112Park (Seung) ADDIN REFMGR.CITE Park SK20044167Self-administered, standardized regimens for multidrug-resistant tuberculosis in South KoreaJournal4167Self-administered, standardized regimens for multidrug-resistant tuberculosis in South KoreaPark SKLee WCLee DHMitnick CDHan LSeung KJ2004tuberculosisNot in File361368Int J Tuberc Lung Dis8Int J Tuberc Lung Dis1[45]1998-2002South Korea
(Masan)HospitalNational TB Hospital (National Masan Tuberculosis Hospital)Standardized131Perez-Guzman (Vargas) ADDIN REFMGR.CITE Prez-Guzmn C20024194Results of a 12-month regimen for drug-resistant pulmonary tuberculosisJournal4194Results of a 12-month regimen for drug-resistant pulmonary tuberculosisPérez-Guzmán CVargas MHMartinez-Rossier LATorres-Cruz AVillarreal-Velarde H2002In File11021109Int J Tuberc Lung Dis6Int J Tuberc Lung Dis1[46] 1994-1995MexicoHospitalPulmonary TB Clinics of the Instituto Nacional de Enfermedades RespiratoriasIndividualized33Quy (Dang/Cobelens) ADDIN REFMGR.CITE Quy HT20064169Treatment outcomes by drug resistance and HIV status among tuberculosis patients in Ho Chi Minh City, VietnamJournal4169Treatment outcomes by drug resistance and HIV status among tuberculosis patients in Ho Chi Minh City, VietnamQuy HTCobelens FGJLan NTNBuu TNLamBregts CSBBorgdorff MW2006treatmentTreatment Outcomedrug resistanceresistanceHIVtuberculosisCitiesNot in File4551Int J Tuberc Lung Dis10Int J Tuberc Lung Dis1[47]1998-2000Vietnam
(Ho Chi Minh City)City
(multi-center)National TB Control ProgramStandardized
(First-line drugs only)157Schaaf (Schaaf) ADDIN REFMGR.CITE Schaaf HS20034171Culture confirmed multidrug resistant tuberculosis: diagnostic delay, clinical features, and outcomeJournal4171Culture confirmed multidrug resistant tuberculosis: diagnostic delay, clinical features, and outcomeSchaaf HSShean KDonald PR2003cultureresistanttuberculosisdiagnosticdelayNot in File11061111Arch.Dis.Child88Arch.Dis.Child1[48]1998-2002South Africa
(Western Cape, Capetown Metropole, West Coast)Multi-regional
(multi-center)MDR-TB clinics &
Local hospitalsIndividualized36Shin (Shin) ADDIN REFMGR.CITE Shin SS20064197Treatment outcomes in an integrated civilian and prison MDR-TB treatment program in RussiaJournal4197Treatment outcomes in an integrated civilian and prison MDR-TB treatment program in RussiaShin SSPasechnikov ADGelmanova IYPeremitin GGStrelis AKAndreev YGGolubchikova VTTonkel TPYanova GVNikiforov MYedibayev AMukherjee JSFurin JJBarry DJFarmer PERich MLKeshavjee S2006treatmentTreatment OutcomeprisonMDR-TBIn File402408Int J Tuberc Lung Dis10Int J Tuberc Lung Dis1[49]2000-2004Russian Federation (Tomsk)Oblast
(multi-center)Tomsk Oblast TB Services, Tomsk Penitentiary Services and Tomsk TB HospitalIndividualized535Shiraishi (Shiraishi) ADDIN REFMGR.CITE Shiraishi Y20044172Resectional surgery combined with chemotherapy remains the treatment of choice for multidrug-resistant tuberculosis Journal4172Resectional surgery combined with chemotherapy remains the treatment of choice for multidrug-resistant tuberculosis Shiraishi YNakalima YKatsuragi NKurai MTakahashi N2004surgerychemotherapytreatmenttuberculosisNot in File523528J Thorac Cardiovasc Surg128J Thorac Cardiovasc Surg1[50]2000-2007Japan
(Tokyo)HospitalFukujuji HospitalIndividualized61Tupasi (Quelapio) ADDIN REFMGR.CITE ADDIN EN.CITE.DATA [51,52]1999-2003Philippines
ClinicMakati Medical Center Dots ClinicIndividualized159Uffredi (Robert) ADDIN REFMGR.CITE Uffredi ML20074173An intervention programme for the management of multidrug-resistant tuberculosis in FranceJournal4173An intervention programme for the management of multidrug-resistant tuberculosis in FranceUffredi MLTruffot-Pernot CDautzenberg BRenard MJarlier VRobert J2007tuberculosisNot in File434439Intl J Antimicrob Agents29Intl J Antimicrob Agents1[53]1998-1999France
(Paris)Multi-regional
National Reference
CenterIndividualized41Van Deun (Aung Maug) ADDIN REFMGR.CITE Van Deun A20044174Results of a standardised regimen for multidrug-resistant tuberculosis in BangladeshJournal4174Results of a standardised regimen for multidrug-resistant tuberculosis in BangladeshVan Deun ASalim MAHDas APKBastian IPortaels F2004tuberculosisNot in File560567Int J Tuberc Lung Dis8Int J Tuberc Lung Dis1Van Deun A20104290Short, highly effective and inexpensive standardized treatment of multidrug-resistant tuberculosisJournal4290Short, highly effective and inexpensive standardized treatment of multidrug-resistant tuberculosisVan Deun AMaug AKJSalim MAHDas PKSarker MRDaru PRieder HL2010shorttreatmenttuberculosisIn File684692Am J Respir Crit Care Med182Am J Respir Crit Care Med1[54,55]1997-2010BangladeshCountry
(multi-center)Bangladesh National TB Program (& Damien Foundation)Standardized603Yew (Leung) ADDIN REFMGR.CITE ADDIN EN.CITE.DATA [56,57]1990-1997Hong KongHospitalTertiary Referral Hospital for TB (Grantham Hospital)Individualized99
*Defined by start date of MDR-TB treatment.
** The data sets initially included 25 patients or more with MDR TB. After excluding patients with extra pulmonary disease, XDR, or who were missing information about treatment or outcomes there were fewer patients from each study in some cases less than 25.
Supplemental Table 1b. Overview of 35 studies excluded from Individual Patient Data Meta-analysis of MDR-TB
For excluded studies (Table S1b), references are included here)
First authorPublication yearYear(s) of treatment and follow-upCountry Patients (N)Cured (%)NotesBartu,V20072001-2004Czech Republic4553%Bashar, M20011987-1997USA - NYC28NAOutcomes aggregated for MDR TB and TB patientsBloch, AB19991993USA44736%Bonnet, M20051997-2002Russia, Georgia, Azerbaijan, Uzbekistan, Turkmenistan, Kazakhstan28271%Outcomes of MDR TB and all TB patients aggregated except at Kemerovo and Abkhasia sitesConinx, R19991995-1998Azerbaijan6025%Corlan, E1997NARomania32NAOutcomes aggregated for MDR and mono-resistant TB Drobniewski, F20021996-1997UK90NAEker, B20082004-2006Germany17759%Espinal, MA20001994-1996 Dominican Republic, Hong Kong, Italy, Russia, South Korea, Peru35341%Fischl, MA19921988-1990USA40NANo outcomes. All patients were HIV+ Flament-Saillour, M19991994-1996France4042%Gandhi, NR20062005-2006South Africa168NANo Outcomes. Surveillance studyGoble, M19931973-1983USA119NANo outcomes Hersi, A19991989-1998Canada2433%Kim, HJ20011988-1996South Korea101148%Kritski, AL19971986-1990Brazil7727%Cured = remained disease-free after mean 20.5 months Lan, NTN20011991-1994Vietnam4214 (33%)Lee, CN19961987-1989Taiwan3617 (47%)Mangunnegoro, H19991995-1996Indonesia5839 (67%)Migliori, GB20021995-1999Russia7618 (24%)Nathanson, E20061999-2001Estonia, Latvia, Peru, Philippines, Russia104770%Olle-Goig, JE20051983-1993Bolivia14329%Park, MM19961983-1994USA - NYC17356% Cured = number alive who completed treatment Pathan, AJ1996NAPakistan2318 (78%)Prete, S19921986-1989France2314 (61%)Sosna, J19991985-1994Israel5721 (37%)Sung, SW19991994-1998South Korea2726 (92%)all patients also underwent pulmonary resection Surucuoglu, S20051997-2003Turkey2614 (54%)Tahalogu, K20011992-1999Turkey158121 (77%)Takeda, S20051988-2003Japan2623 (89%)all patients also underwent pulmonary resection Telzak, EE19951991-1995USA - NYC2516 (64%)Trn, T20051992-2004Turkey263204 (78%)Turett, GS19951991-1993USA - NYC3824 (63%)Cured = number with microbiological and clinical response to treatmentVan Leuven, M19971990-1995South Africa624 (7%)all patients also underwent pulmonary resection Ward, HA20051989-2000Vietnam4438 (86%)Total (N)5340
References for Table S1b (Excluded Studies)
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(2) Bashar M, Alcabes P, Rom WN, Condos R. Increased incidence of multidrug-resistant tuberculosis in diabetic patients on the Bellvue Chest Service, 1987 to 1997. Chest 2001;120(5):1514-9.
(3) Bloch AB, Cauthen GM, Simone PM, Kelly GD, Dansbury KG, Castro KG. Completion of tuberculosis therapy for patients reported in the United States in 1993. Int J Tuberc Lung Dis 1999;3(4):273-80.
(4) Bonnet M, Sizaire V, Kebede Y, Janin A, Doshtetov D, Mirzoian B, Arzumanian A, Muminov T, Iona E, Rigouts L, Rusch-Gerdes S, Varaine F. Does one size fit all? Drug resistance and standard treatments: results of six tuberculosis programmes in former Soviet countries. Int J Tuberc Lung Dis 2005;9(10):1147-54.
(5) Coninx R, Mathieu C, Debacker M, Mirzoev F, Ismaelov A, de Haller R, Meddings DR. First-line tuberculosis therapy and drug-resistant Mycobacterium tuberculosis in prisons. The Lancet 1999;353:969-73.
(6) Corlan E, Marica C, Macavei C, Stanford JL, Standford CA. Immunotherapy with Mycobacterium vaccae in the treatment of tuberculosis in Romania. 2. chronic or relaped disease. Respiratory Medicine 1997:91:21-9.
(7) Drobniewski F, Elktringham I, Graham C, Magee JG, Smith EG, Watt B. A national study of clinical and laboratory factors affecting the survival of patients with multiple drug resistant tuberculosis in the UK. Thorax 2002;57:810-6.
(8) Ecker Barbara, Ortman J, Migliori GB, Sotgiu G, Muetterlein R, Centis R, Hoffmann H, Kirsten D, Schaberg T, Ruesch-Gerdes S, Lange C, for the German TBNET Group. Multidrug- and extensively drug-resistant tuberculosis, Germany. Emerging Infectious Diseases 2008;14(11):1700-6.
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(11) Flament-saillour M, Robert J, Jarlier V, Grosset J. Outcome of multi-drug-resistant tuberculosis in France a nationwide case-control study. Am J Respir Crit Car Med 1999;160:587-93.
(12) Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. The Lancet 2006;368:1575-80.
(13) Goble M, Iseman MD, Madsen LA, Waite D, Ackerson L, Horsburgh, Jr. R. Treatement of 171 patients with pulmonary tuberculosis resistant to Isoniazid and Rifampin. N Engl J Med 1993; 328(8):527-32.
(14) Hersi A, Elwood K, Cowie R, Kunimoto D, Long R. Multidrug-resistant tuberculosis in Alberta and British Columbia, 1989 to 1998. Can Respir J 199;6(2):155-60.
(15) Kim HJ, Hong YP, Kim SJ, Lew WJ, Lee EG. Ambulatory treatment of multidrug-resistant pulmonary tuberculosis patients at a chest clinic. Int J Tuberc Lung Dis 2001;5(12):1129-36.
(16) Kritski AL, Rodrigues de Jesus LS, Andrade MK, Werneck-Barroso E, Vieira MAMS, Haffner A, Riley LW. Retreatment tuberculosis cases factors associated with drug resistance and adverse outcomes. Chest 1997;111:1162-7.
(17) Lan NTN, Iademarco MF, Binkin NJ, Tung LB, Quy HT, Co NV. A case series: initial outcome of persons with multidrug-resistant tuberculosis after treatment with the WHO standard retreatment regimen in Ho Chi Minh City, Vietnam. Int J Tuberc Lung Dis 2001;5(6):575-8.
(18) Lee CN, Lin TP, Chang MF, Jimenez MV, Dolfi L, Olliario P. Rifabutin as salvage therapy for cases of chronic multidrug-resistant pulmonary tuberculosis in Taiwan. Journal of Chemotherapy 1996;8(2):137-43.
(19) Mangunnegoro H, Hudoyo A. Efficacy of low-dose Ofloxacin in the treatment of multidrug-resistant tuberculosis in Indonesia. Chemotherapy 1999;45(suppl 2):19-25.
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(21) Nathanson E, Weezenbeek CL, Rich ML, Gupta R, Bayona J, Blondal K, Caminero JA, Cegielski JP, Danilovits M, Espinal MA, Hollo V, Jaramillo E, Leimane V, Mitnick CD, Mukherjee JS, Nunn P, Pasechnikov A, Tupasi T, Wells C, Raviglione MC. Multidrug-resistant tuberculosis management in resource-limited settings. Emerging Infectious Diseases 2006;12(9):11389-97.
(22) Oll-Goig JE, Sandy R. Outcomes of individualised treatment for multidrug-resistant tuberculosis before DOTS-Plus. Int J Tuberc Dis 2005;9(7):765-70.
(23) Park MM, Davis AL, Schluger NW, Cohen H, Rom WN. Outcome of MDR-TB patients, 1983-1993. Am J Respir Crit Care Med 1996;153:317-24.
(24) Pathan AJ, Khan AA. Treatment of short course chemotherapy (SHRZE) failure cases with Kanamycin, Ethionamide and Cycloserine. Pakistans J Med Sci 1996;12(2):101-6.
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(26) Sonsa J, Schulimzon T, Roznman J, Lidgi M, Lavy A, Ben-Dov IZ, Ben-Dov I. Drug-resistant pulmonary tuberculosis in Israel, a society of immigrants: 1985-1994. Int J Tuberc Lung Dis 3(8):689-94.
(27) Sung SW, Kang CH, Kim YT, Han SK, Shim Y-S, Kim JH. Surgery increased the chance of cure in multi-drug resistant pulmonary tuberculosis. European Journal of Cardio-thoracic Surgery 1999;16:197-93.
(28) Surucuoglu S, Ozkutuk N, Celik P, Gazi H, Dinc G, Kurutepe S, Koroglu G, Havlucu Y, Tuncay G. Drug-resistant pulmonary tuberculosis in western Turkey: prevalence, clinical characterisitcs and treatment outocme. Ann Saudi Med 2005;25(4):313-8.
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(31) Telzak EE, Sepkowitz K, Alpert P, Mannheimer S, Medard F, El-Sadr W, Blum S, Gagliardi A, Salomon N, Turrett G. Multidrug-resistant tuberculosis in patients without HIV infection. N Engl J Med 1995;333(14):907-11.
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(33) Turett GS, Telzak EE, Torian LV, Blum S, Alland D, Weisfuse I, Fazal BA. Improved outcomes for patients with multidrug-resistant tuberculosis. Clinical Infectious Diseases 1995;21:1238-44.
(34) Van Leuven M, De Groot M, Shean KP, Von Oppel UO, Willcox PA. Pulmonary resection as an adjunct in the treatment of multiple drug-resistant tuberculosis. Ann Thorac Surg 1997;63:1368-73.
(35) Ward HA, Marciniuk DD, Hoeppner VH, Jones W. Treatment outcomes of multidrug-resistant tuberculosis among Vietnamese immigrants. Int J Tuberc Lung Dis 2005;9(2):164-9.
PAGE
IPD Meta-analysis on MDR-TB treatment outcomes
PAGE 10
First Author (Contact Person - if different)CureTreatment CompletedTreatment DefaultTreatment FailureTreatment Relapse
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