Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center

Morgan, Rebecca A.; Karl, Julie A.; Bussan, Hailey E.; Heimbruch, Katelyn E.; O’Connor, David H.; Dudley, Dawn M.

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Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center

Supporting Files

March 28 2018
By Morgan, Rebecca A. ; Karl, Julie A. ; Bussan, Hailey E. ; ...

File Language:

English

Details

Alternative Title:

Immunogenetics
Personal Author:

Morgan, Rebecca A. ; Karl, Julie A. ; Bussan, Hailey E. ; Heimbruch, Katelyn E. ; O’Connor, David H. ; Dudley, Dawn M.
Description:

Baboons are valuable models for complex human diseases due to their genetic and physiologic similarities to humans. Deep sequencing methods to characterize full-length major histocompatibility complex (MHC) class I (MHC-I) alleles in different nonhuman primate populations were used to identify novel MHC-I alleles in baboons. We combined data from Illumina MiSeq sequencing and Roche/454 sequencing to characterize novel full-length MHC-I transcripts in a cohort of olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center (SNPRC). We characterized 57 novel full-length alleles from 24 baboons and found limited genetic diversity at the MHC-I A locus, with significant sharing of two MHC-I A lineages between 22 out of the 24 animals characterized. These shared alleles provide the basis for development of tools such as MHC:peptide tetramers for studying cellular immune responses in this important animal model.
Subjects:

Alleles Animals Article Baboon Gene Frequency Genes, MHC Class I Genetic Variation Haplotypes High-Throughput Nucleotide Sequencing Histocompatibility Antigens Class I Illumina MiSeq Sequencing Major Histocompatibility Complex Major Histocompatibility Complex I Papio Anubis Papio Anubis Cynocephalus Papio Cynocephalus Papio Hamadryas Phylogeny Primates Roche/454 Pyrosequencing
Source:

Immunogenetics. 70(7):449-458
Pubmed ID:

29594415
Pubmed Central ID:

PMC8130456
Document Type:

Journal Article
Funding:

HHSN272201600007C/AI/NIAID NIH HHS/United States ; P51 OD011106/OD/NIH HHS/United States ; P51 RR000167/RR/NCRR NIH HHS/United States ; P51 OD011106/CD/ODCDC CDC HHS/United States
Volume:

70
Issue:

7
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:d3453651e60b0b0c1bdbfb3a35a5e6a8f465bce41044ec1b8318e4c32f408dec
Download URL:

https://stacks.cdc.gov/view/cdc/106348/cdc_106348_DS1.pdf
File Type:

[PDF - 576.39 KB ]

File Language:

English

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