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Massively multiplexed nucleic acid detection with Cas13

CITE Title : Massively multiplexed nucleic acid detection with Cas13 Personal Author(s) : Ackerman, Cheri M.;Myhrvold, Cameron;Thakku, Sri Gowtham;Freije, Catherine A.;Metsky, Hayden C.;Yang, David K.;Ye, Simon H.;Boehm, Chloe K.;Kosoko-Thoroddsen, Tinna-Sólveig F.;Kehe, Jared;Nguyen, Tien G.;Carter, Amber;Kulesa, Anthony;Barnes, John R.;Dugan, Vivien G.;Hung, Deborah T.;Blainey, Paul C.;Sabeti, Pardis C.; Published Date : April 29 2020 Source : Nature. 582(7811):277-282 URL : https://stacks.cdc.gov/view/cdc/92508 Ackerman, Cheri M. et al. (2020). Massively multiplexed nucleic acid detection with Cas13. 582(7811). Ackerman, Cheri M. et al. "Massively multiplexed nucleic acid detection with Cas13" 582, no. 7811 (2020) Ackerman, Cheri M. et al. "Massively multiplexed nucleic acid detection with Cas13" vol. 582, no. 7811, 2020 Export RIS Citation Information.

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Ackerman, Cheri M. ;

Myhrvold, Cameron

April 29 2020 | Nature. 582(7811):277-282

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The great majority of globally circulating pathogens go undetected, undermining patient care and hindering outbreak preparedness and response. To enab...
GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

CITE Title : GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases Personal Author(s) : Tsai, Shengdar Q.;Zheng, Zongli;Nguyen, Nhu T.;Liebers, Matthew;Topkar, Ved V.;Thapar, Vishal;Wyvekens, Nicolas;Khayter, Cyd;Iafrate, A. John;Le, Long P.;Aryee, Martin J.;Joung, J. Keith; Published Date : Dec 16 2014 Source : Nat Biotechnol. 33(2):187-197 URL : https://stacks.cdc.gov/view/cdc/30281 Tsai, Shengdar Q. et al. (2014). GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. 33(2). Tsai, Shengdar Q. et al. "GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases" 33, no. 2 (2014) Tsai, Shengdar Q. et al. "GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases" vol. 33, no. 2, 2014 Export RIS Citation Information.

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Tsai, Shengdar Q. ;

Zheng, Zongli

Dec 16 2014 | Nat Biotechnol. 33(2):187-197

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CRISPR RNA-guided nucleases (RGNs) are widely used genome-editing reagents, but methods to delineate their genome-wide, off-target cleavage activities...
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

CITE Title : Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity Personal Author(s) : Ran, F. Ann;Hsu, Patrick D.;Lin, Chie-Yu;Gootenberg, Jonathan S.;Konermann, Silvana;Trevino, Alexandro;Scott, David A.;Inoue, Azusa;Matoba, Shogo;Zhang, Yi;Zhang, Feng; Published Date : Aug 29 2013 Source : Cell. 2013; 154(6):1380-1389. URL : https://stacks.cdc.gov/view/cdc/29797 Ran, F. Ann et al. (2013). Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. 154(6). Ran, F. Ann et al. "Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity" 154, no. 6 (2013) Ran, F. Ann et al. "Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity" vol. 154, no. 6, 2013 Export RIS Citation Information.

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Ran, F. Ann ;

Hsu, Patrick D.

Aug 29 2013 | Cell. 2013; 154(6):1380-1389.

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Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas ...
Crystal structure of Staphylococcus aureus Cas9

CITE Title : Crystal structure of Staphylococcus aureus Cas9 Personal Author(s) : Nishimasu, Hiroshi;Cong, Le;Yan, Winston X.;Ran, F. Ann;Zetsche, Bernd;Li, Yinqing;Kurabayashi, Arisa;Ishitani, Ryuichiro;Zhang, Feng;Nureki, Osamu; Published Date : Aug 27 2015 Source : Cell. 162(5):1113-1126. URL : https://stacks.cdc.gov/view/cdc/36575 Nishimasu, Hiroshi et al. (2015). Crystal structure of Staphylococcus aureus Cas9. 162(5). Nishimasu, Hiroshi et al. "Crystal structure of Staphylococcus aureus Cas9" 162, no. 5 (2015) Nishimasu, Hiroshi et al. "Crystal structure of Staphylococcus aureus Cas9" vol. 162, no. 5, 2015 Export RIS Citation Information.

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Nishimasu, Hiroshi ;

Cong, Le

Aug 27 2015 | Cell. 162(5):1113-1126.

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The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA....
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

CITE Title : BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Personal Author(s) : Canver, Matthew C.;Smith, Elenoe C.;Sher, Falak;Pinello, Luca;Sanjana, Neville E.;Shalem, Ophir;Chen, Diane D.;Schupp, Patrick G.;Vinjamur, Divya S.;Garcia, Sara P.;Luc, Sidinh;Kurita, Ryo;Nakamura, Yukio;Fujiwara, Yuko;Maeda, Takahiro;Yuan, Guo-Cheng;Feng, Zhang;Orkin, Stuart H.;Bauer, Daniel E.; Published Date : Sep 16 2015 Source : Nature. 527(7577):192-197. URL : https://stacks.cdc.gov/view/cdc/36479 Canver, Matthew C. et al. (2015). BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. 527(7577). Canver, Matthew C. et al. "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis" 527, no. 7577 (2015) Canver, Matthew C. et al. "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis" vol. 527, no. 7577, 2015 Export RIS Citation Information.

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Canver, Matthew C. ;

Smith, Elenoe C.

Sep 16 2015 | Nature. 527(7577):192-197.

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Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although...
DNA targeting specificity of RNA-guided Cas9 nucleases

CITE Title : DNA targeting specificity of RNA-guided Cas9 nucleases Personal Author(s) : Hsu, Patrick D.;Scott, David A.;Weinstein, Joshua A;Ran, F. Ann;Konermann, Silvana;Agarwala, Vineeta;Li, Yinqing;Fine, Eli J.;Wu, Xuebing;Shalem, Ophir;Cradick, Thomas J.;Marraffini, Luciano A.;Bao, Gang;Zhang, Feng; Published Date : Jul 21 2013 Source : Nat Biotechnol. 2013; 31(9):827-832. URL : https://stacks.cdc.gov/view/cdc/29899 Hsu, Patrick D. et al. (2013). DNA targeting specificity of RNA-guided Cas9 nucleases. 31(9). Hsu, Patrick D. et al. "DNA targeting specificity of RNA-guided Cas9 nucleases" 31, no. 9 (2013) Hsu, Patrick D. et al. "DNA targeting specificity of RNA-guided Cas9 nucleases" vol. 31, no. 9, 2013 Export RIS Citation Information.

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Hsu, Patrick D. ;

Scott, David A.

Jul 21 2013 | Nat Biotechnol. 2013; 31(9):827-832.

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The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to genomic loci by means of single-guide RNAs (sgRNAs) to enable genome ...
Rationally engineered Cas9 nucleases with improved specificity

CITE Title : Rationally engineered Cas9 nucleases with improved specificity Personal Author(s) : Slaymaker, Ian M.;Gao, Linyi;Zetsche, Bernd;Scott, David A.;Yan, Winston X.;Zhang, Feng; Published Date : Dec 01 2015 Source : Science. 351(6268):84-88. URL : https://stacks.cdc.gov/view/cdc/37554 Slaymaker, Ian M. et al. (2015). Rationally engineered Cas9 nucleases with improved specificity. 351(6268). Slaymaker, Ian M. et al. "Rationally engineered Cas9 nucleases with improved specificity" 351, no. 6268 (2015) Slaymaker, Ian M. et al. "Rationally engineered Cas9 nucleases with improved specificity" vol. 351, no. 6268, 2015 Export RIS Citation Information.

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Slaymaker, Ian M. ;

Gao, Linyi

Dec 01 2015 | Science. 351(6268):84-88.

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The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of g...
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

CITE Title : Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA Personal Author(s) : Nishimasu, Hiroshi;Ran, F. Ann;Hsu, Patrick D.;Konermann, Silvana;Shehata, Soraya;Dohmae, Naoshi;Ishitani, Ryuichiro;Zhang, Feng;Nureki, Osamu; Published Date : Feb 13 2014 Source : Cell. 156(5):935-949. URL : https://stacks.cdc.gov/view/cdc/30086 Nishimasu, Hiroshi et al. (2014). Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA. 156(5). Nishimasu, Hiroshi et al. "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA" 156, no. 5 (2014) Nishimasu, Hiroshi et al. "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA" vol. 156, no. 5, 2014 Export RIS Citation Information.

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Nishimasu, Hiroshi ;

Ran, F. Ann

Feb 13 2014 | Cell. 156(5):935-949.

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The CRISPR-associated endonuclease Cas9 can be targeted to specific genomic loci by single guide RNAs (sgRNAs). Here, we report the crystal structure ...
CRISPR RNA-guided activation of endogenous human genes

CITE Title : CRISPR RNA-guided activation of endogenous human genes Personal Author(s) : Maeder, Morgan L;Linder, Samantha J;Cascio, Vincent M;Fu, Yanfang;Ho, Quan H;Joung, J Keith; Published Date : Jul 25 2013 Source : Nat Methods. 10(10):977-979. URL : https://stacks.cdc.gov/view/cdc/22527 Maeder, Morgan L et al. (2013). CRISPR RNA-guided activation of endogenous human genes. 10(10). Maeder, Morgan L et al. "CRISPR RNA-guided activation of endogenous human genes" 10, no. 10 (2013) Maeder, Morgan L et al. "CRISPR RNA-guided activation of endogenous human genes" vol. 10, no. 10, 2013 Export RIS Citation Information.

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Maeder, Morgan L ;

Linder, Samantha J

Jul 25 2013 | Nat Methods. 10(10):977-979.

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Short guide RNAs (gRNAs) can direct catalytically inactive CRISPR-associated 9 nuclease (dCas9) to repress endogenous genes in bacteria and human cell...