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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

CITE Title : Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex Personal Author(s) : Konermann, Silvana;Brigham, Mark D.;Trevino, Alexandro E.;Joung, Julia;Abudayyeh, Omar O.;Barcena, Clea;Hsu, Patrick D.;Habib, Naomi;Gootenberg, Jonathan S.;Nishimasu, Hiroshi;Nureki, Osamu;Zhang, Feng; Published Date : Dec 10 2014 Source : Nature. 517(7536):583-588. URL : https://stacks.cdc.gov/view/cdc/30833 Konermann, Silvana et al. (2014). Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. 517(7536). Konermann, Silvana et al. "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" 517, no. 7536 (2014) Konermann, Silvana et al. "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex" vol. 517, no. 7536, 2014 Export RIS Citation Information.

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Konermann, Silvana ;

Brigham, Mark D.

Dec 10 2014 | Nature. 517(7536):583-588.

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Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe struc...
Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems

CITE Title : Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems Personal Author(s) : Shmakov, Sergey;Abudayyeh, Omar O.;Makarova, Kira S.;Wolf, Yuri I;Gootenberg, Jonathan S.;Semenova, Ekaterina;Minakhin, Leonid;Joung, Julia;Konermann, Silvana;Severinov, Konstantin;Zhang, Feng;Koonin, Eugene V.; Published Date : Oct 22 2015 Source : Mol Cell. 60(3):385-397. URL : https://stacks.cdc.gov/view/cdc/37888 Shmakov, Sergey et al. (2015). Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems. 60(3). Shmakov, Sergey et al. "Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems" 60, no. 3 (2015) Shmakov, Sergey et al. "Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems" vol. 60, no. 3, 2015 Export RIS Citation Information.

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Shmakov, Sergey ;

Abudayyeh, Omar O.

Oct 22 2015 | Mol Cell. 60(3):385-397.

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Microbial CRISPR-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with single protein effectors. Currently, on...
In vivo genome editing using Staphylococcus aureus Cas9

CITE Title : In vivo genome editing using Staphylococcus aureus Cas9 Personal Author(s) : Ran, F. Ann;Cong, Le;Yan, Winston X.;Scott, David A.;Gootenberg, Jonathan S.;Kriz, Andrea J.;Zetsche, Bernd;Shalem, Ophir;Wu, Xuebing;Makarova, Kira S.;Koonin, Eugene;Sharp, Phillip A.;Zhang, Feng; Published Date : Apr 01 2015 Source : Nature. 520(7546):186-191. URL : https://stacks.cdc.gov/view/cdc/30379 Ran, F. Ann et al. (2015). In vivo genome editing using Staphylococcus aureus Cas9. 520(7546). Ran, F. Ann et al. "In vivo genome editing using Staphylococcus aureus Cas9" 520, no. 7546 (2015) Ran, F. Ann et al. "In vivo genome editing using Staphylococcus aureus Cas9" vol. 520, no. 7546, 2015 Export RIS Citation Information.

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Ran, F. Ann ;

Cong, Le

Apr 01 2015 | Nature. 520(7546):186-191.

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The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus py...
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

CITE Title : Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity Personal Author(s) : Ran, F. Ann;Hsu, Patrick D.;Lin, Chie-Yu;Gootenberg, Jonathan S.;Konermann, Silvana;Trevino, Alexandro;Scott, David A.;Inoue, Azusa;Matoba, Shogo;Zhang, Yi;Zhang, Feng; Published Date : Aug 29 2013 Source : Cell. 2013; 154(6):1380-1389. URL : https://stacks.cdc.gov/view/cdc/29797 Ran, F. Ann et al. (2013). Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. 154(6). Ran, F. Ann et al. "Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity" 154, no. 6 (2013) Ran, F. Ann et al. "Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity" vol. 154, no. 6, 2013 Export RIS Citation Information.

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Ran, F. Ann ;

Hsu, Patrick D.

Aug 29 2013 | Cell. 2013; 154(6):1380-1389.

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Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas ...
Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease

CITE Title : Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease Personal Author(s) : Dahlman, James E.;Abudayyeh, Omar O.;Joung, Julia;Gootenberg, Jonathan S.;Zhang, Feng;Konermann, Silvana; Published Date : 11 2015;11-2015; Source : Nat Biotechnol. 33(11):1159-1161 URL : https://stacks.cdc.gov/view/cdc/37904 Dahlman, James E. et al. (2015). Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease. 33(11). Dahlman, James E. et al. "Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease" 33, no. 11 (2015) Dahlman, James E. et al. "Orthogonal gene knock out and activation with a catalytically active Cas9 nuclease" vol. 33, no. 11, 2015 Export RIS Citation Information.

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Dahlman, James E. ;

Abudayyeh, Omar O.

11 2015 | Nat Biotechnol. 33(11):1159-1161

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We have developed a CRISPR-based method that uses catalytically active Cas9 and distinct single guide (sgRNA) constructs to knock out and activate dif...
Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system

CITE Title : Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system Personal Author(s) : Zetsche, Bernd;Gootenberg, Jonathan S.;Abudayyeh, Omar O.;Slaymaker, Ian M.;Makarova, Kira S.;Essletzbichler, Patrick;Volz, Sara;Joung, Julia;van der Oost, John;Regev, Aviv;Koonin, Eugene V.;Zhang, Feng; Published Date : 10 22 2015;10-22-; Source : Cell. 163(3):759-771 URL : https://stacks.cdc.gov/view/cdc/37605 Zetsche, Bernd et al. (2015). Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system. 163(3). Zetsche, Bernd et al. "Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system" 163, no. 3 (2015) Zetsche, Bernd et al. "Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas system" vol. 163, no. 3, 2015 Export RIS Citation Information.

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Zetsche, Bernd ;

Gootenberg, Jonathan S.

10 22 2015 | Cell. 163(3):759-771

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The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Cl...
Structure and Engineering of Francisella novicida Cas9

CITE Title : Structure and Engineering of Francisella novicida Cas9 Personal Author(s) : Hirano, Hisato;Gootenberg, Jonathan S.;Horii, Takuro;Abudayyeh, Omar O.;Kimura, Mika;Hsu, Patrick D.;Nakane, Takanori;Ishitani, Ryuichiro;Hatada, Izuho;Zhang, Feng;Nishimasu, Hiroshi;Nureki, Osamu; Published Date : Feb 11 2016 Source : Cell. 164(5):950-961. URL : https://stacks.cdc.gov/view/cdc/40093 Hirano, Hisato et al. (2016). Structure and Engineering of Francisella novicida Cas9. 164(5). Hirano, Hisato et al. "Structure and Engineering of Francisella novicida Cas9" 164, no. 5 (2016) Hirano, Hisato et al. "Structure and Engineering of Francisella novicida Cas9" vol. 164, no. 5, 2016 Export RIS Citation Information.

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Hirano, Hisato ;

Gootenberg, Jonathan S.

Feb 11 2016 | Cell. 164(5):950-961.

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The RNA-guided endonuclease Cas9 cleaves double-stranded DNA targets complementary to the guide RNA and has been applied to programmable genome editin...
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

CITE Title : C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector Personal Author(s) : Abudayyeh, Omar O.;Gootenberg, Jonathan S.;Konermann, Silvana;Joung, Julia;Slaymaker, Ian M.;Cox, David B.T.;Shmakov, Sergey;Makarova, Kira S.;Semenova, Ekaterina;Minakhin, Leonid;Severinov, Konstantin;Regev, Aviv;Lander, Eric S.;Koonin, Eugene V.;Zhang, Feng; Published Date : Jun 02 2016 Source : Science. 353(6299):aaf5573. URL : https://stacks.cdc.gov/view/cdc/42943 Abudayyeh, Omar O. et al. (2016). C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. 353(6299). Abudayyeh, Omar O. et al. "C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector" 353, no. 6299 (2016) Abudayyeh, Omar O. et al. "C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector" vol. 353, no. 6299, 2016 Export RIS Citation Information.

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Abudayyeh, Omar O. ;

Gootenberg, Jonathan S.

Jun 02 2016 | Science. 353(6299):aaf5573.

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The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against fo...