Long-term Consistency in Rotavirus Vaccine Protection: RV5 and RV1 Vaccine Effectiveness in US Children, 2012–2013

Payne, Daniel C.; Selvarangan, Rangaraj; Azimi, Parvin H.; Boom, Julie A.; Englund, Janet A.; Staat, Mary Allen; Halasa, Natasha B.; Weinberg, Geoffrey A.; Szilagyi, Peter G.; Chappell, James; McNeal, Monica; Klein, Eileen J.; Sahni, Leila C.; Johnston, Samantha H.; Harrison, Christopher J.; Baker, Carol J.; Bernstein, David I.; Moffatt, Mary E.; Tate, Jacqueline E.; Mijatovic-Rustempasic, Slavica; Esona, Mathew D.; Wikswo, Mary E.; Curns, Aaron T.; Sulemana, Iddrisu; Bowen, Michael D.; Gentsch, Jon R.; Parashar, Umesh D.

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Long-term Consistency in Rotavirus Vaccine Protection: RV5 and RV1 Vaccine Effectiveness in US Children, 2012–2013

October 08 2015
By Payne, Daniel C. ; Selvarangan, Rangaraj ; Azimi, Parvin H. ; ...
Source: Clin Infect Dis. 61(12):1792-1799

[PDF-772.90 KB]

English

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Details:

Alternative Title:

Clin Infect Dis
Personal Author:

Payne, Daniel C. ; Selvarangan, Rangaraj ; Azimi, Parvin H. ; Boom, Julie A. ; Englund, Janet A. ; ... More +

Payne, Daniel C. ; Selvarangan, Rangaraj ; Azimi, Parvin H. ; Boom, Julie A. ; Englund, Janet A. ; Staat, Mary Allen ; Halasa, Natasha B. ; Weinberg, Geoffrey A. ; Szilagyi, Peter G. ; Chappell, James ; McNeal, Monica ; Klein, Eileen J. ; Sahni, Leila C. ; Johnston, Samantha H. ; Harrison, Christopher J. ; Baker, Carol J. ; Bernstein, David I. ; Moffatt, Mary E. ; Tate, Jacqueline E. ; Mijatovic-Rustempasic, Slavica ; Esona, Mathew D. ; Wikswo, Mary E. ; Curns, Aaron T. ; Sulemana, Iddrisu ; Bowen, Michael D. ; Gentsch, Jon R. ; Parashar, Umesh D. Less -
Description:

Background

Using a multicenter, active surveillance network from 2 rotavirus seasons (2012 and 2013), we assessed the vaccine effectiveness of RV5 (RotaTeq) and RV1 (Rotarix) rotavirus vaccines in preventing rotavirus gastroenteritis hospitalizations and emergency department (ED) visits for numerous demographic and secular strata.

Methods

We enrolled children hospitalized or visiting the ED with acute gastroenteritis (AGE) for the 2012 and 2013 seasons at 7 medical institutions. Stool specimens were tested for rotavirus by enzyme immunoassay and genotyped, and rotavirus vaccination histories were compared for rotavirus-positive cases and rotavirus-negative AGE controls. We calculated the vaccine effectiveness (VE) for preventing rotavirus associated hospitalizations and ED visits for each vaccine, stratified by vaccine dose, season, clinical setting, age, predominant genotype, and ethnicity.

Results

RV5-specific VE analyses included 2961 subjects, 402 rotavirus cases (14%) and 2559 rotavirus-negative AGE controls. RV1-specific VE analyses included 904 subjects, 100 rotavirus cases (11%), and 804 rotavirus-negative AGE controls. Over the 2 rotavirus seasons, the VE for a complete 3-dose vaccination with RV5 was 80% (confidence interval [CI], 74%–84%), and VE for a complete 2-dose vaccination with RV1 was 80% (CI, 68%–88%).

Conclusions

In this large, geographically and demographically diverse sample of US children, we observed that RV5 and RV1 rotavirus vaccines each provided a lasting and broadly heterologous protection against rotavirus gastroenteritis.
Subjects:

[+]

Acute Gastroenteritis Antigens, Viral Article Child Child, Preschool Emergency Medical Services Enzyme-Linked Immunosorbent Assay Epidemiological Monitoring Feces Female Gastroenteritis Genotype Hospitalization Humans Infant Male RNA, Viral Rotavirus Infections Rotavirus Vaccine Rotavirus Vaccines RV1-Rotarix RV5-RotaTeq Surveillance Treatment Outcome United States Vaccines, Attenuated
Source:

Clin Infect Dis. 61(12):1792-1799
Pubmed ID:

26449565
Pubmed Central ID:

PMC7724934
Document Type:

Journal Article
Funding:

U01 IP000458/IP/NCIRD CDC HHS/United States ; IP11-010/IP/NCIRD CDC HHS/United States

U01 IP000458/IP/NCIRD CDC HHS/United States ; IP11-010/IP/NCIRD CDC HHS/United States Less -
Volume:

61
Issue:

12
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:08c2f0bdc339e3c3901f7f5a8a424fbdf23cfab81ecd7b6adabe2d7f5c801264
Download URL:

https://stacks.cdc.gov/view/cdc/98605/cdc_98605_DS1.pdf
File Type:

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