i
24-Hour Profile of Serum Sclerostin and Its Association With Bone Biomarkers in Men
-
Jul 26 2017
-
-
Source: Osteoporos Int. 28(11):3205-3213.
[PDF-561.63 KB]
Details:
-
Alternative Title:Osteoporos Int
-
Personal Author:
-
Description:Purpose
The osteocyte exerts important effects on bone remodeling but its rhythmicity and effect on the rhythms of other bone cells are not fully characterized. The purpose of this study was to determine if serum sclerostin displays rhythmicity over a 24-hour (h) interval, similar to that of other bone biomarkers.
Methods
Serum sclerostin, FGF-23, CTX, and P1NP were measured every 2 hours over a 24-h interval on 10 healthy men aged 20-65 years. Maximum likelihood estimates of the parameters in a repeated measures model were used to determine if these biomarkers displayed a diurnal, sinusoidal rhythm.
Results
No discernible 24-h rhythm was identified for sclerostin (p = 0.99) or P1NP (p = 0.65). CTX rhythmicity was confirmed (p < 0.001), peaking at 05:30 (range 01:30–07:30). FGF-23 levels were also rhythmic (p < 0.001) but time of peak was variable (range 02:30-11:30). The only significant association identified between these four bone biomarkers was for CTX and P1NP mean 24-h metabolite levels (r = 0.65, p = 0.04).
Conclusions
Sclerostin levels do not appear to be rhythmic in men. This suggests that in contrast to CTX, serum sclerostin could be measured at any time of day. The 24-h profiles of FGF-23 suggest that a component of osteocyte function is rhythmic but its timing is variable. Our results do not support the hypothesis that osteocytes direct the rhythmicity of other bone turnover markers (CTX), at least not via a sclerostin mediated mechanism.
-
Subjects:
-
Source:
-
Pubmed ID:28744601
-
Pubmed Central ID:PMC5859541
-
Document Type:
-
Funding:
-
Volume:28
-
Issue:11
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
