NIOSH Skin Notation (SK) Profile: Heptachlor [CAS No. 76-44-8]

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  No quantitative data on the dermal absorption kinetics of heptachlor were identified. A mathematical model predicted heptachlor is not likely to be absorbed through the skin. However, acute toxicity studies in rats [Gaines 1960, 1969] showed that the chemical has the potential to be absorbed through the skin, systemically available, and toxic following acute dermal exposure. No studies were identified that evaluated the potential of heptachlor to be corrosive or irritating to the skin or be a skin sensitizer. A structure- activity relationship model predicted heptachlor to be negative for skin irritation, but a plausible skin sensitizer. Skin sensitization potential predicted by the model highlights testing for this endpoint as an important data gap. Therefore, on the basis of these assessments, heptachlor is assigned a composite skin notation of SK: SYS. Table 3 summarizes the skin hazard designations for heptachlor previously issued by NIOSH and other organizations. The equivalent dermal designation for heptachlor, according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Epidemiology Hazardous Substances Laboratories Occupational Health Risk Assessment Risk Factors Safety Skin Toxicology

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• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute toxicity; Laboratory testing; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Dermal-exposure; Exposure assessment; In vivo studies; Dermal absorption; In vitro studies; Lethal dose; Carcinogens; Humans; Systematic reviews; Heptachlor; Humans; Skin sensitivity; Sensitizers; GHS; Globally Harmonized System of Classification and Labeling of Chemicals
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-186, 2017 Aug; :1-9
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2017186
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20050227
• NTIS Accession Number:
  PB2018-100169
• CAS Registry Number:
  Heptachlor (CAS RN 76-44-8)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dfe7feb3c5f1ac475df8068bf7f26470e5000f9e5dd7fade06d2332027e8bf510c228eb5907b185ffdb6fc0a07da09985f427cc210b3c2750f1591dfd3daab4b
• Download URL:
  https://stacks.cdc.gov/view/cdc/47652/cdc_47652_DS1.pdf
• File Type:
  [PDF - 223.02 KB ]