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Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March–June 2015
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Aug 2017
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Source: Emerg Infect Dis. 23(8):1308-1315.
[PDF-1.20 MB]
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Alternative Title:Emerg Infect Dis
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Description:In 2015, a cluster of respiratory diphtheria cases was reported from KwaZulu-Natal Province in South Africa. By using whole-genome analysis, we characterized 21 Corynebacterium diphtheriae isolates collected from 20 patients and contacts during the outbreak (1 patient was infected with 2 variants of C. diphtheriae). In addition, we included 1 cutaneous isolate, 2 endocarditis isolates, and 2 archived clinical isolates (ca. 1980) for comparison. Two novel lineages were identified, namely, toxigenic sequence type (ST) ST-378 (n = 17) and nontoxigenic ST-395 (n = 3). One archived isolate and the cutaneous isolate were ST-395, suggesting ongoing circulation of this lineage for >30 years. The absence of preexisting molecular sequence data limits drawing conclusions pertaining to the origin of these strains; however, these findings provide baseline genotypic data for future cases and outbreaks. Neither ST has been reported in any other country; this ST appears to be endemic only in South Africa.
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Pubmed ID:28726616
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Pubmed Central ID:PMC5547784
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Volume:23
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Issue:8
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