Increasing Incidence of Extended-Spectrum β-Lactamase-Producing Escherichia coli in Community Hospitals throughout the Southeastern United States

Details

• Alternative Title:
  Infect Control Hosp Epidemiol
• Personal Author:
  Thaden, Joshua T. ; Fowler, Vance G. ; Sexton, Daniel J. ; Anderson, Deverick J.
• Description:
  OBJECTIVE
  
  To describe the epidemiology of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP) infections
  
  DESIGN
  
  Retrospective cohort
  
  SETTING
  
  Inpatient care at community hospitals
  
  PATIENTS
  
  All patients with ESBL-EC or ESBL-KP infections
  
  METHODS
  
  ESBL-EC and ESBL-KP infections from 26 community hospitals were prospectively entered into a centralized database from January 2009 to December 2014.
  
  RESULTS
  
  A total of 925 infections caused by ESBL-EC (10.5 infections per 100,000 patient days) and 463 infections caused by ESBL-KP (5.3 infections per 100,000 patient days) were identified during 8,791,243 patient days of surveillance. The incidence of ESBL-EC infections increased from 5.28 to 10.5 patients per 100,000 patient days during the study period (P =.006). The number of community hospitals with ESBL-EC infections increased from 17 (65%) in 2009 to 20 (77%) in 2014. The median ESBL-EC infection rates among individual hospitals with ≥1 ESBL-EC infection increased from 11.1 infections/100,000 patient days (range, 2.2–33.9 days) in 2009 to 22.1 infections per 100,000 patient days (range, 0.66–134 days) in 2014 (P =.05). The incidence of ESBL-KP infections remained constant over the study period (P = .14). Community-associated and healthcare-associated ESBL-EC infections trended upward (P =.006 and P = .02, respectively), while hospital-onset infections remained stable (P = .07). ESBL-EC infections were more common in females (54% vs 44%, P < .001) and Caucasians (50% vs 40%, P < .0001), and were more likely to be isolated from the urinary tract (61% vs 52%, P < .0001) than ESBL-KP infections.
  
  CONCLUSIONS
  
  The incidence of ESBL-EC infection has increased in community hospitals throughout the southeastern United States, while the incidence of ESBL-KP infection has remained stable. Community- and healthcare-associated ESBL-EC infections are driving the upward trend.
  
  
• Subjects:
  Article
• Source:
  Infect Control Hosp Epidemiol. 37(1):49-54.
• Pubmed ID:
  26458226
• Pubmed Central ID:
  PMC4748740
• Document Type:
  Journal Article
• Funding:
  K23 AI095357/AI/NIAID NIH HHS/United States ; K23 AI095357/AI/NIAID NIH HHS/United States ; K24 AI093969/AI/NIAID NIH HHS/United States ; R01AI068804/AI/NIAID NIH HHS/United States ; U54 CK000164/CK/NCEZID CDC HHS/United States
• Volume:
  37
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f6df789de4ba4224afdcca4f837bb32c28aa6f3f532347e981b9581672e837a1
• Download URL:
  https://stacks.cdc.gov/view/cdc/38873/cdc_38873_DS1.pdf
• File Type:
  [PDF - 549.14 KB ]