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Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisis
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Sep 17 2015
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Source: J Perinatol. 35(11):930-934.
[PDF-586.41 KB]
Details:
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Alternative Title:J Perinatol
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Description:Objective
To investigate the association between Chlamydia trachomatis (CT) infection seropositivity and gastroschisis.
Study Design
In this case-control study we enrolled pregnant women either prenatally diagnosed with gastroschisis (cases, n=33) or with a normal ultrasound (controls, n=66). Both groups attended the University of Utah's Maternal Fetal Medicine Diagnostic Center for their diagnostic ultrasound or because of a community obstetrician referral. Participants completed a structured interview on potential risk factors. Anti-CT IgG1 and IgG3 were measured by a CT elementary body ELISA.
Result
Median age at sexual debut was lower and reported sexual partner number higher in cases compared to controls. Risk factors for gastroschisis included having ≥3 sexual partners (OR=3.3, 95% CI 1.2, 9.4), change in partner from the previous pregnancy (OR=3.6, 95% CI 0.9, 13.9), and anti-CT IgG3 seropositivity (age-adjusted OR=3.9, 95% CI: 1.1, 13.2).
Conclusion
Anti-CT IgG3 seropositivity was associated with greater than a 3-fold risk for gastroschisis.
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Pubmed ID:26378912
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Pubmed Central ID:PMC4626386
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Volume:35
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Issue:11
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