Mycobacterium abscessus Complex Infections in Humans

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lee, Meng-Rui ; Sheng, Wang-Huei ; Hung, Chien-Ching ; Yu, Chong-Jen ; Lee, Li-Na ; Hsueh, Po-Ren
• Description:
  Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections. M. abscessus complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. The 2 major subspecies, M. abscessus subsp. abscessus and M. abscessus subsp. massiliense, have different erm(41) gene patterns. This gene provides intrinsic resistance to macrolides, so the different patterns lead to different treatment outcomes. M. abscessus complex outbreaks associated with cosmetic procedures and nosocomial transmissions are not uncommon. Clarithromycin, amikacin, and cefoxitin are the current antimicrobial drugs of choice for treatment. However, new treatment regimens are urgently needed, as are rapid and inexpensive identification methods and measures to contain nosocomial transmission and outbreaks.
• Subjects:
  Anti-Bacterial Agents Communicable Diseases, Emerging Drug Resistance, Bacterial Global Health Humans Mycobacterium Mycobacterium Infections
• Source:
  Emerg Infect Dis. 21(9):1638-1646
• Pubmed ID:
  26295364
• Pubmed Central ID:
  PMC4550155
• Document Type:
  Journal Article
• Volume:
  21
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:a6d7348878b91adb89aa96fceb81a3fc02031e7008fd7eaee2da6002f763b1ec2990cb5755e577223b35b568c50538f93ad8a5098e6d49a355888b9f853d581d
• Download URL:
  https://stacks.cdc.gov/view/cdc/33138/cdc_33138_DS1.pdf
• File Type:
  [PDF - 1.25 MB ]