DNA Fingerprinting of Mycobacterium tuberculosis Isolates from Epidemiologically Linked Case Pairs

Bennett, Diane E.; Onorato, Ida M.; Ellis, Barbara A.; Crawford, Jack T.; Schable, Barbara; Byers, Robert; Kammerer, J. Steve; Braden, Christopher R.

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DNA Fingerprinting of Mycobacterium tuberculosis Isolates from Epidemiologically Linked Case Pairs

Public Domain

Nov 2002
By Bennett, Diane E. ; Onorato, Ida M. ; Ellis, Barbara A. ; ...

File Language:

English

Details

Alternative Title:

Emerging Infectious Diseases
Personal Author:

Bennett, Diane E. ; Onorato, Ida M. ; Ellis, Barbara A. ; Crawford, Jack T. ; Schable, Barbara ; Byers, Robert ; Kammerer, J. Steve ; Braden, Christopher R.
Description:

DNA fingerprinting was used to evaluate epidemiologically linked case pairs found during routine tuberculosis (TB) contact investigations in seven sentinel sites from 1996 to 2000. Transmission was confirmed when the DNA fingerprints of source and secondary cases matched. Of 538 case pairs identified, 156 (29%) did not have matching fingerprints. Case pairs from the same household were no more likely to have confirmed transmission than those linked elsewhere. Case pairs with unconfirmed transmission were more likely to include a smear-negative source case (odds ratio [OR] 2.0) or a foreign-born secondary case (OR 3.4) and less likely to include a secondary case <15 years old (OR 0.3). Our study suggests that contact investigations should focus not only on the household but also on all settings frequented by an index case. Foreign-born persons with TB may have been infected previously in high-prevalence countries; screening and preventive measures recommended by the Institute of Medicine could prevent TB reactivation in these cases.
Subjects:

Adolescent Adult Aged Child Contact Tracing Dispatch DNA, Bacterial DNA Fingerprinting Female Humans Male Middle Aged Sentinel Surveillance Tuberculosis
Source:

Emerging Infectious Diseases. 8(11):1124-1129.
Document Type:

Journal Article
Place as Subject:

United States
Location:

North America
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:8b4ca73c1e7c6ac09070dcc604b0f114a246db1f81483731f2876039cf9888595afe56f000fbf7832fa5988067cc5345d95426d94ee97fcb0f50c531d6753366
Download URL:

https://stacks.cdc.gov/view/cdc/3124/cdc_3124_DS1.pdf
File Type:

[PDF - 240.91 KB ]

File Language:

English

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