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Scaling of Gene Expression with Transcription-Factor Fugacity
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Dec 16 2014
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Source: Phys Rev Lett. 2014; 113(25):258101.
[PDF-1.04 MB]
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Alternative Title:Phys Rev Lett
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Description:The proteins associated with gene regulation are often shared between multiple pathways simultaneously. By way of contrast, models in regulatory biology often assume these pathways act independently. We demonstrate a framework for calculating the change in gene expression for the interacting case by decoupling repressor occupancy across the cell from the gene of interest by way of a chemical potential. The details of the interacting regulatory architecture are encompassed in an effective concentration, and thus, a single scaling function describes a collection of gene expression data from diverse regulatory situations and collapses it onto a single master curve.
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Pubmed ID:25554908
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Pubmed Central ID:PMC4386862
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Volume:113
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Issue:25
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