Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

de Steenwinkel, Jurriaan E.M.; ten Kate, Marian T.; de Knegt, Gerjo J.; Kremer, Kristin; Aarnoutse, Rob E.; Boeree, Martin J.; Verbrugh, Henri A.; van Soolingen, Dick; Bakker-Woudenberg, Irma A.J.M.

doi:10.3201/eid1804.110912

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

Apr 2012
By de Steenwinkel, Jurriaan E.M. ; ten Kate, Marian T. ; de Knegt, Gerjo J. ; ...
http://dx.doi.org/10.3201/eid1804.110912
Source: Emerg Infect Dis. 18(4):660-663.

[PDF-378.24 KB]

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

de Steenwinkel, Jurriaan E.M. ; ten Kate, Marian T. ; de Knegt, Gerjo J. ; Kremer, Kristin ; Aarnoutse, Rob E. ; ... More +

de Steenwinkel, Jurriaan E.M. ; ten Kate, Marian T. ; de Knegt, Gerjo J. ; Kremer, Kristin ; Aarnoutse, Rob E. ; Boeree, Martin J. ; Verbrugh, Henri A. ; van Soolingen, Dick ; Bakker-Woudenberg, Irma A.J.M. Less -
Description:

To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.
Subjects:

[+]

Amikacin Antimicrobial Resistances Antitubercular Agents Antituberculosis Drugs Aza Compounds Bacterial Proteins Beijing Genotype Strains Dispatch Drug Resistance, Multiple, Bacterial Emergence Genotype Isoniazid Mdr Tb Microbial Sensitivity Tests Multidrug-Resistant Tuberculosis Mutation Mycobacterium Tuberculosis Quinolines Resistance Rifampin Statistics, Nonparametric Tuberculosis, Multidrug-Resistant Tuberculosis And Other Mycobacteria
Source:

Emerg Infect Dis. 18(4):660-663.
Document Type:

Journal Article
Volume:

18
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:250a67ff0076fc6d017059c38912f9849e52ae6b3f985725726b05a6112b317a
Download URL:

https://stacks.cdc.gov/view/cdc/23860/cdc_23860_DS1.pdf
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