Viral Etiology of Influenza-Like Illnesses in Antananarivo, Madagascar, July 2008 to June 2009

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Razanajatovo, Norosoa Harline ; Richard, Vincent ; Hoffmann, Jonathan ; Reynes, Jean-Marc ; Razafitrimo, Girard Marcellin ; Randremanana, Rindra Vatosoa ; Heraud, Jean-Michel
• Description:
  Background
  
  In Madagascar, despite an influenza surveillance established since 1978, little is known about the etiology and prevalence of viruses other than influenza causing influenza-like illnesses (ILIs).
  
  Methodology/Principal Findings
  
  From July 2008 to June 2009, we collected respiratory specimens from patients who presented ILIs symptoms in public and private clinics in Antananarivo (the capital city of Madagascar). ILIs were defined as body temperature ≥38°C and cough and at least two of the following symptoms: sore throat, rhinorrhea, headache and muscular pain, for a maximum duration of 3 days. We screened these specimens using five multiplex real time Reverse Transcription and/or Polymerase Chain Reaction assays for detection of 14 respiratory viruses. We detected respiratory viruses in 235/313 (75.1%) samples. Overall influenza virus A (27.3%) was the most common virus followed by rhinovirus (24.8%), RSV (21.2%), adenovirus (6.1%), coronavirus OC43 (6.1%), influenza virus B (3.9%), parainfluenza virus-3 (2.9%), and parainfluenza virus-1 (2.3%). Co-infections occurred in 29.4% (69/235) of infected patients and rhinovirus was the most detected virus (27.5%). Children under 5 years were more likely to have one or more detectable virus associated with their ILI. In this age group, compared to those ≥5 years, the risk of detecting more than one virus was higher (OR = 1.9), as was the risk of detecting of RSV (OR = 10.1) and adenovirus (OR = 4.7). While rhinovirus and adenovirus infections occurred year round, RSV, influenza virus A and coronavirus OC43 had defined period of circulation.
  
  Conclusions
  
  In our study, we found that respiratory viruses play an important role in ILIs in the Malagasy community, particularly in children under 5 years old. These data provide a better understanding of the viral etiology of outpatients with ILI and describe for the first time importance of these viruses in different age group and their period of circulation.
  
  
• Subjects:
  Adolescent Adult Child Child, Preschool Demography Female Humans Incidence Infant Infant, Newborn Influenza, Human Male Seasons Viruses Virus Physiological Phenomena Young Adult

  More +
• Source:
  PLoS One. 6(3).
• Pubmed ID:
  21390235
• Pubmed Central ID:
  PMC3048401
• Document Type:
  Journal Article
• Funding:
  U51/IP000327-01/IP/NCIRD CDC HHS/United States
• Place as Subject:
  Madagascar
• Volume:
  6
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:63b8f770102f1a686df6432bb1522a7ad48686ac18ce040e7544fdbf30b52abc
• Download URL:
  https://stacks.cdc.gov/view/cdc/22858/cdc_22858_DS1.pdf
• File Type:
  [PDF - 217.79 KB ]