Transport and Deposition of Hygroscopic Particles in Asthmatic Subjects with and Without Airway Narrowing

Details

• Personal Author:
  Babiskin A ; Choi J ; Choi S ; Delvadia R ; Hoffman EA ; Lin C-L ; O'Shaughnessy PT ; Rajaraman PK ; Walenga R
• Description:
  This study numerically investigates the effect of hygroscopicity on transport and deposition of particles in severe asthmatic lungs with distinct airway structures. The study human subjects were selected from two imaging-based severe asthmatic clusters with one characterized by non-constricted airways and the other by constricted airways in the lower left lobe (LLL). We compared the deposition fractions of sodium chloride (NaCl) particles with a range of aerodynamic diameters (1-8 microm) in cluster archetypes under conditions with and without hygroscopic growth. The temperature and water vapor distributions in the airways were simulated with an airway wall boundary condition that accounts for variable temperature and water vapor evaporation at the interface between the lumen and the airway surface liquid layer. On average, the deposition fraction increased by about 6% due to hygroscopic particle growth in the cluster subjects with constricted airways, while it increased by only about 0.5% in those with non-constricted airways. The effect of particle growth was most significant for particles with an initial diameter of 2 microm in the cluster subjects with constricted airways. The effect diminished with increasing particle size, especially for particles with an initial diameter larger than 4 microm. This suggests the necessity to differentiate asthmatic subjects by cluster in engineering the aerosol size for tailored treatment. Specifically, the treatment of severe asthmatic subjects who have constricted airways with inhalation aerosols may need submicron-sized hygroscopic particles to compensate for particle growth, if one targets for delivering to the peripheral region. These results could potentially inform the choice of particle size for inhalational drug delivery in a cluster-specific manner. [Description provided by NIOSH]
• Subjects:
  Aerosols Asthma Asthma, Occupational Occupational Health Particulate Matter Respiratory System Safety Solvents
• Keywords:
  Airway Resistance Author Keywords: Airway Constriction Cluster Analysis Computational Fluid Dynamics Hygroscopic Growth Inhalation Particle Aerodynamics Particle Deposition Particle Size Respiratory Function Vapors

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• ISSN:
  0021-8502
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Maryland ; OSHA Region 3 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  146
• NIOSHTIC Number:
  nn:20062638
• Citation:
  J Aerosol Sci 2020 Aug; 146:105581
• Contact Point Address:
  Ching-Long Lin, 2406 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242, USA
• Email:
  ching-long-lin@uiowa.edu
• CAS Registry Number:
  Sodium chloride (CAS RN 7647-14-5)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Aerosol Science
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:76ef54896c43fd88fbbc88a61af4728e50c07ab2b67373f5df8df3640f6fd6ae8166917934284926a48fbf952eb14bf0f0985082f75caed41afcc2a99fab25db
• Download URL:
  https://stacks.cdc.gov/view/cdc/225843/cdc_225843_DS1.pdf
• File Type:
  [PDF - 2.47 MB ]