The Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Risk Assessment

Details

• Personal Author:
  Lu Y ; Yang RSH
• Description:
  The area of science called physiologically based pharmacokinetic (PBPK) modeling can be traced back to the 1920s. ln June 2005, the first book on PBPK (Reddy, Yang, Clewell, and Andersen, 2005) was published and its contents encompassed over one thousand publications on PBPK modeling. Despite the fact that it is a mature science with almost one hundred years of history, active development is still going on in this area and a later section of this chapter provides a glimpse of some of these latest advances. It is important to emphasize that this chapter, though a learning tool, only provides some of the fundamentals to stimulate your interests. Alone, it will not make you a PBPK modeler. To be proficient, there is no alternative but to attend specific training workshops, and most important, to get your hands dirty by doing PBPK modeling yourself: Only through repeated practice, reacting, and making all the mistakes everyone else has made before you will you then open the window to a very useful and powerful technology. [Description provided by NIOSH]
• Subjects:
  Biochemistry Carcinogens Computers Occupational Health Radiation Dosimeters Safety Software Toxicology
• Keywords:
  Biochemical Analysis Biological Effects Chemical Kinetics Computer Equipment Computer Programs Dose Response Dosimetry Models Molecular Biology Pharmacodynamics Physiological Response

  More +
• ISBN:
  9780787983192
• Publisher:
  Jossey-Bass
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  85-120
• NIOSHTIC Number:
  nn:20052188
• Citation:
  Risk assessment for environmental health. Robson MG, Toscano WA, eds. San Francisco, CA: Jossey-Bass, 2007 Feb; :85-120
• Editor(s):
  Robson MG; Toscano WA
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Research Tools and Approaches: Risk Assessment Methods
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20010601
• Source Full Name:
  Risk assessment for environmental health
• End Date:
  20040531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c96db8dc9f9431bc93594da8136b5cccf834ef2f10b68164f7f496fd4acb5fd6ff31ac79b311d591cfbbc7dc323a629572240bb80f91b181804c434600d89aa4
• Download URL:
  https://stacks.cdc.gov/view/cdc/211762/cdc_211762_DS1.pdf
• File Type:
  [PDF - 27.61 MB ]