Modeling Chemical Sensitivity: Prior Exposure to Stress and Pesticide Affects Neuroinflammatory Response to Subsequent Exposures in Mice

Details

• Personal Author:
  Kelly KA ; Michalovicz LT ; O'Callaghan JP
• Description:
  Background and Purpose: Chemical sensitivity is a multi-symptom illness that results from sensitization to chemicals or mixtures following an initiating exposure and presents with symptoms including neurologic and cognitive dysfunction, depression, and anxiety, as well as respiratory and gastrointestinal issues. While many chemicals have been associated with development of chemical sensitivity, pesticides are one of the most common sensitizing agents. Previously, we have found that stress potentiates neuroinflammatory responses to organophosphate pesticides, such as chlorpyrifos and dichlorvos (DDVP), which is associated with long-term neuroimmune disorders such as Gulf War Illness (GWI). Interestingly, neuroinflammation is associated with the physiological and behavioral responses of "sickness behavior," whose symptoms share similarities with chemical sensitivity and long-term disorders like GWI. Methods: To evaluate the role of neuroinflammation in chemical sensitivity, adult male C57BL/6 mice were exposed corticosterone (CORT) for 7 days to mimic high physiological stress followed by exposure to DDVP; then, the mice were exposed to several other chemical and biological agents 7 days after the initial DDVP exposure, including DDVP, physostigmine, permethrin, and lipopolysaccharide. Results: The evaluation of inflammatory cytokine mRNA in the brain and peripheral tissues indicated that prior exposure to CORT DDVP exacerbated the expression of several cytokines compared to controls. Conclusions: These data suggest the potential involvement of neuroinflammation in the development of chemical sensitivity, which will be further investigated by future behavioral studies and evaluation of longer-term time points. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Immune System Insecticides Occupational Health Safety
• Keywords:
  Chemical Hypersensitivity Dichlorvos Immune Reaction Neurological Diseases Pesticides Sensitization Stress
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  198
• NIOSHTIC Number:
  nn:20069354
• Citation:
  Toxicologist 2024 Mar; 198(S1):549
• CAS Registry Number:
  Chlorpyrifos (CAS RN 2921-88-2) ; Dichlorvos (CAS RN 62-73-7)
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 63rd Annual Meeting & ToxExpo, March 10-14, 2024, Salt Lake City, Utah
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:85f9bf84371dd3ae06790ad8b7f8da374a78ffe458820a7acb43c94aadb0d483c9dee6c7e17fc10603c62be25663f910509af630dff09e43abab5e9c9ede427d
• Download URL:
  https://stacks.cdc.gov/view/cdc/207851/cdc_207851_DS1.pdf
• File Type:
  [PDF - 540.59 KB ]