The effects of JP8 jet fuel on serum endocrine concentrations in men: risk assessment of acute exposure to jet fuel

Details

• Personal Author:
  Kesner JS ; Knecht EA ; Krieg EF Jr. ; Lemasters GK ; Reutman SR
• Description:
  Evidence from. animal and human studies suggest that components of JP8 jet fuel can disrupt the neuroendocrine axes that control or impact the reproductive and immunologic systems. Human studies have demonstrated reduced secretion of luteinizing hormone (LH) associated with toluene and JP8 exposure. LH is critical for reproductive performance, but also effects immunologic functions by increasing interleukins involved in natural killer cell activation and B-cell differentiation. Adrenocorticopic hormone, follicle stimulating hormone (FSH), prolactin, corticosterone, testosterone, and estradiol also regulate immune function and are affected by compounds in fuels and exhaust JP8 represents the most common chemical exposure among members of the Armed Forces. The specific objective of this aspect of the study is to determine endocrine levels in the peripheral blood and Whether these endocrine concentrations are associated with JP8 exposure or other work conditions. Information gathered in this study would help the National Institute for Occupational Safety and Health (NIOSH) establish recommended exposure limits for military and civilian aviation. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Immune System Occupational Health Risk Assessment Risk Factors Safety Toluene Urogenital System
• Keywords:
  Air Force Personnel Aviation Exposure Exposure Levels Immune System Jet Engine Fuels Jet Propellant Type 8 JP-8 Kidney Function Kidneys Liver Liver Enzymes Liver Function Physiology Reproductive System Risk Factors Toluenes

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• Publisher:
  Air Force Institute for Operational Health
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  91-96
• NIOSHTIC Number:
  nn:20048828
• Citation:
  JP8: final risk assessment. Kendall RK, Smith E, eds. Brooks City-Base, TX: Air Force Institute for Operational Health, 2001 Aug; :91-96
• Editor(s):
  Kendall RK; Smith E
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  JP8: final risk assessment
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07978b507e430f026ae1ac7bb02017b5b4a6204cee3affd16b8c6e0584df0bf9214c3ad166912307639f45addb7c693ac28e708ee2bd603a289e92ce6362fe1c
• Download URL:
  https://stacks.cdc.gov/view/cdc/203459/cdc_203459_DS1.pdf
• File Type:
  [PDF - 855.58 KB ]