Evolution of the Science of Developmental Immunotoxicity

Details

• Personal Author:
  Luster M
• Description:
  The value of incorporating immunological data for the toxicological assessment of drugs, chemicals, biologicals and medical devices for human risk assessment has been increasingly accepted. Since the 1970s, experimental animal studies, and to a lesser extent human studies, have been published describing immunological effects in neonates exposed to toxic agents during the prenatal or early postnatal period . Of particular concern was that immunotoxicity often appeared more severe and/or persistent when the exposure occurred perinatally when compared to exposure in adult animals. These concerns were addressed in a 1993 report from the National Research Council (NRC) entitled Pesticides in the Diets of Infants and Children in which the immune, as well as the reproductive and nervous systems, were identified as potential targets for pesticide exposure. Efforts are presently being undertaken to identify appropriate methods and approaches to identify and study developmental immunotoxicants. In addition to immunosuppression, there is increasing evidence that transplacental priming of the immune system occurs in response to certain environmental agents which possess allergic or inflammatory properties. This subsequently results in T-helper 1 (Th1) or, more often, T-helper 2 (Th2) skewing of the immune system. Consistent with this general postulate is experimental and clinical evidence that individuals exposed early in life to these environmental agents are predispose to increased prevalence and/or severity of immune diseases. [Description provided by NIOSH]
• Subjects:
  Animals Hazardous Substances Insecticides Laboratories Nervous System Occupational Health Safety Urogenital System
• Keywords:
  Animal-studies Drugs Exposure-levels Immune-system Immunological-tests Immunotoxins Laboratory-animals Nervous-system Pesticides Reproductive-system Toxic-effects

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• ISSN:
  1096-6080
• Publisher:
  Society of Toxicology
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  72
• NIOSHTIC Number:
  nn:20022670
• Citation:
  Toxicologist 2003 Mar; 72(S-1):225
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 42nd Annual Meeting and ToxExpo, Cutting-Edge Science, Networking, New Perspectives, March 9-13, 2003, Salt Lake City, Utah
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d490a212ed4a443926ab521f4a8afd131552afbe49a6b8c5976a3d4139d7514efbdb7221420438119237483b6c2bba5b844edbe13f88bd8fe90266b38f6e388c
• Download URL:
  https://stacks.cdc.gov/view/cdc/199364/cdc_199364_DS1.pdf
• File Type:
  [PDF - 56.66 KB ]