Role of Inflammation in Chemical-Induced Hepatotoxicity

Details

• Personal Author:
  Blazka ME ; Bruccoleri A ; Gallucci RM ; Luster MI ; Simeonova PP ; Yucesoy, Berran
• Description:
  The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators that can effect liver damage or repair. This review will summarize our current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride, an industrial chemical, and acetaminophen, a widely used analgesic. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Hazardous Substances Liver Occupational Health Safety
• Keywords:
  Analgesics Author Keywords: Inflammatory Cytokines Chemical-induced Hepatotoxicity Diseases Exposure-levels Hepatotoxicity Hepatotoxins Immunotoxicology Immunotoxins Liver-damage Liver-function Toxic-effects Toxins

  More +
• ISSN:
  0378-4274
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; Oklahoma ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  317-321
• Volume:
  120
• Issue:
  1
• NIOSHTIC Number:
  nn:20021799
• Citation:
  Toxicol Lett 2001 Mar; 120(1-3):317-321
• Contact Point Address:
  Michael I. Luster, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505, USA
• Email:
  mluster@cdc.gov
• CAS Registry Number:
  Carbon tetrachloride (CAS RN 56-23-5)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ccdd40fe8a60fd29cc7793ec687d7ecc9c01d1fbe7e1140af0929c9a1b2f9feb38d58ed042126be5c5800dda74cea089ad0342347a2ced520d898edd475c019d
• Download URL:
  https://stacks.cdc.gov/view/cdc/198904/cdc_198904_DS1.pdf
• File Type:
  [PDF - 148.98 KB ]