A proposed mechanism of the gene Ahl for increased susceptibility to noise-induced hearing loss

Details

• Personal Author:
  Davis, Rickie R. ; Erway LC ; Kozel P
• Description:
  Animals and humans show differing susceptibility to noise damage even under very carefully controlled exposure conditions. This difference in susceptibility may be related to an uncontrolled genetic component. Common experimental animals (rats, guinea pigs, chinchillas, cats) are outbred?their genomes contain an admixture of many genes. About 10 years ago Erway et al (1993) demonstrated a recessive gene associated with early presbycusis in inbred mice: Ahl. A series of studies have shown that mice homozygous for Ahl are more sensitive to the damaging effects of noise. Recent work has shown that mice homozygous for Ahl are not only more sensitive to noise, but also are probably damaged in a different manner by noise than mice containing the wild-type gene. Recent work in Noben-Trauth?s lab (Di Palma et al., 2001) has shown that the wild-type Ahl gene codes for an outer-hair cell specific cadherin. Cadherins are calcium dependent proteins which hold cells together at adherins junctions to form tissues and organs. The cadherin of interest is localized to outer hair and has been termed otocadherin or cdh-23. Reduction in, or missing otocadherin may allow stereocilia to be more easily physically damaged by loud sounds and by aging. [Description provided by NIOSH]
• Subjects:
  Animals Hearing Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Occupational Health Safety
• Keywords:
  Animal-studies Cell-damage Cellular-reactions Exposure-levels Hearing-disorders Hearing-loss Laboratory-animals Noise-exposure Noise-induced-hearing-loss
• ISSN:
  0742-3152
• Publisher:
  Association for Research in Otolaryngology
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Florida ; Missouri ; New Jersey ; Ohio ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  131-132
• Volume:
  26
• NIOSHTIC Number:
  nn:20041685
• Citation:
  Abstr Midwinter Res Meet Assoc Res Otolaryngol 2003 Feb; 22:131-132
• Editor(s):
  Santi PA
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Disease and Injury: Hearing Loss
• Performing Organization:
  Washington University
• Peer Reviewed:
  False
• Start Date:
  20000401
• Source Full Name:
  Abstracts of the 26th Midwinter Research Meeting of the Association for Research in Otolaryngology, Febuary 22-27, 2003, Daytona Beach, Florida
• End Date:
  20130914
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fdc83ec85052ba1293382a64332a7f38edfec59166811a1e7b3b31ba803fcb032ccb9eec8e8a1d3342c52ba0b303b393d0c801e00bdcad0864eef7ad53c6096f
• Download URL:
  https://stacks.cdc.gov/view/cdc/194178/cdc_194178_DS1.pdf
• File Type:
  [PDF - 173.72 KB ]