Bio-Calorimeter System to Measure the Metabolic Rate of Laboratory Animals After Inhalation Exposure to Toxic Materials

Details

• Personal Author:
  Fedan, Jeffery S. ; Frazer DG ; Goldsmith E ; Goldsmith WT ; Huffman JS ; McKinney WG ; Reynolds JS ; Smith J
• Description:
  Metabolic rate of animals can be affected by a variety of toxic agents. Virtual instrument software was developed to capture and display data provided by a modified direct calorimeter. The calorimeter system was evaluated by examining four groups of rats (n=6) injected with thyroxine(T4) or solvent alone. Half of each group was exposed to ozone (2 ppm for 3 hours) or air. Breathing rates in addition to metabolic rates were measured pre-exposure, immediately post-exposure and 18 hours post-exposure. Metabolic rates were computed following equilibration which occurred in ten to twenty minutes. The calorimeter system provides non-invasive, reproducible results which can be used to evaluate an animal's metabolic response to toxic materials. In addition, the system displays and saves the data in real time and is easily operated. [Description provided by NIOSH]
• Subjects:
  Animals Energy Metabolism Environmental Monitoring Laboratories Occupational Health Safety Software
• Keywords:
  Analytical-methods Analytical-processes Animal-studies Computer-software Exposure-assessment Laboratory-animals Metabolic-rate
• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  159
• Issue:
  3
• NIOSHTIC Number:
  nn:20028308
• Citation:
  Am J Respir Crit Care Med 1999 Mar; 159(3)(Suppl):A490
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:09ca6eaf8fdcdf1909b81fd4e3ed4b5f0953c45d724a25ff7742c7b7b13735700b4e182e16555439c31e503d107fc36eafb0b5b499cc3f0ba84fb426b2da55dc
• Download URL:
  https://stacks.cdc.gov/view/cdc/189833/cdc_189833_DS1.pdf
• File Type:
  [PDF - 407.55 KB ]