Reduction of Carcinogenic Chromium(vi) on the Skin of Living Rats

Details

• Personal Author:
  Liu KJ ; Mader K ; Shi X ; Swartz HM
• Description:
  The reduction of chromate (Cr(VI)) on the skin of living rats was investigated using the technique of in vivo electron paramagnetic resonance (EPR) spectroscopy with a surface coil resonator. Topical application of aqueous solution of Cr(VI) on the skin of rats generated the transient species, Cr(V). Partial removal of the stratum corneum increased the rates of formation and decay of Cr(V), as well as Cr(V) signal intensity. The results demonstrate that skin represents one route for chromium to enter into animals and humans. The generation of reactive Cr(V) species in the reduction of Cr(VI) by the skin may play an important role in the mechanism of Cr(VI)-induced skin cancer. These findings indicate the potential for in vivo EPR spectroscopy for studying the metabolism of paramagnetic reactive species in chemical and biochemical reactions occurring in/on the skin of both small and large animals, and possibly humans. [Description provided by NIOSH]
• Subjects:
  Animals Chromium Environmental Monitoring Laboratories Metals Metals, Heavy Neoplasms Occupational Health Safety Skin Skin Absorption Skin Diseases

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• Keywords:
  Animal-studies Chromium-compounds Exposure-assessment Exposure-levels Heavy-metals Laboratory-animals Metal-compounds Metallic-compounds Skin-absorption Skin-cancer Skin-exposure Skin-tests

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• ISSN:
  0740-3194
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New Hampshire ; OSHA Region 1 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  38
• Issue:
  4
• NIOSHTIC Number:
  nn:20034009
• Citation:
  Magn Reson Med 1997 Oct; 38(4):524-526
• Contact Point Address:
  Ke Jian Liu, Dartmouth Medical School, 7785 Remsen, Room 620, Hanover, NH 03755
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Chromium(6+) (CAS RN 18540-29-9)
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  Magnetic Resonance in Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0bffbd1e824b31a1fe375daf46c4d69f19e11792100c46c2a3153dabe8c7476458a122585d58bfc948003fa3b3e33baae8224c891c31596b8d214e011fcc6553
• Download URL:
  https://stacks.cdc.gov/view/cdc/189398/cdc_189398_DS1.pdf
• File Type:
  [PDF - 299.57 KB ]