Lymph Node Silicosis and Pulmonary Silicosis: An Autopsy Study

Details

• Personal Author:
  Cox-Ganser, Jean M. ; Ducatman B ; Maymind M ; Saffiotti U ; Stead J
• Description:
  Background: Lymph node silicosis (LS) may increase the likelihood of parenchymal silicosis (PS). During a pilot study on lung cancer and silicosis, using autopsy tissue and exposure data from German uranium miners, we investigated this hypothesis. Design: from a large East German autopsy archive, 1957-1992, we selected 302 former uranium miners: 205 cases of presumed lung cancer and 97 cases dying of other causes. Autopsy slides on 292 cases were reviewed by 4 pathologists; 251 were graded for LS and PS by at least two pathologists. Estimates of silica exposure (Si-Exp) were available for all. In a multi-variable logistic analysis model, the presence of lymph node silicosis was highly significant for the outcome of PS with a substantial odds ratio of 7. Conclusion: In our autopsy cross-sectional analysis study, the majority of PS cases (88%) also had LS. Those cases or LS alone had lower cumulative silica exposures than those cases with a combination of LS and PS. These data support the hypothesis that LS may precede PS. [Description provided by NIOSH]
• Subjects:
  Chemistry Epidemiology Hypersensitivity Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Chemical-hypersensitivity Chemical-properties Chemical-reactions Chemical-synthesis Lung-cancer Lung-cells Pulmonary-disorders Silicate-miners Silicosis Statistical-analysis
• ISSN:
  0023-6837
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  81
• Issue:
  1
• NIOSHTIC Number:
  nn:20033701
• Citation:
  Lab Invest 2001 Jan; 81(1):6a
• CAS Registry Number:
  Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  Laboratory Investigation
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:158afd641d3c1ded93952ec758608f1a2e3ae982639793c36cc428ea9c5031bf2f59c01fc44c93c09e14c5a040a44e8bff950b1c817877c51190e8d024fe57fd
• Download URL:
  https://stacks.cdc.gov/view/cdc/189174/cdc_189174_DS1.pdf
• File Type:
  [PDF - 6.17 MB ]