Understanding Biophysicochemical Interactions at the Nano-Bio Interface

Details

• Personal Author:
  Castranova, Vincent ; Hoek EMV ; Klaessig F ; Madler L ; Nel AE ; Somasundaran P ; Thompson M ; Velegol D ; Xia, T.
• Description:
  Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nano materials. [Description provided by NIOSH]
• Subjects:
  Biochemistry Microbiology Occupational Health Particulate Matter Safety
• Keywords:
  Biochemical-analysis Biochemical-indicators Biodynamics Biological-effects Biological-monitoring Biomedical-engineering Cell-biology Cell-function Cell-morphology Cell-transformation Cellular-function Cellular-reactions Exposure-methods Microscopic-analysis Microscopy Nanotechnology Particle-aerodynamics Particulate-dust Particulates

  More +
• ISSN:
  1476-1122
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  7
• NIOSHTIC Number:
  nn:20035578
• Citation:
  Nat Mater 2009 Jul; 8(7):543-557
• Contact Point Address:
  Andre E. Nel, Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095
• Email:
  anel@mednet.ucla.edu
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nature Materials
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4eb76063c702d057cc14fa8499eb781a51c9e7f60e88d92273be7075e28a06a89d9860019f8e3ad7c2e4a48e0666d1d1cd6622e49f4399cf099f0ac11816c173
• Download URL:
  https://stacks.cdc.gov/view/cdc/187396/cdc_187396_DS1.pdf
• File Type:
  [PDF - 2.60 MB ]