Relationship Between Cumulative Effects of Smoking and Memory CD4+ T Lymphocyte Subpopulations

Details

• Personal Author:
  Araki S ; Fujioka Y ; Haratani T ; Irie M ; Nakata A ; Takahashi M
• Description:
  Previous studies have found that smoking is a strong factor that increases peripheral blood CD4+ T lymphocytes. However, most studies did not assess the cumulative long-life exposure of smoking on differential lymphocyte populations. In this study, to clarify the association of smoking habits and circulating lymphocytes, we conducted a cross-sectional study of 60 male current smokers. Smoking status was estimated by number of cigarettes smoked per day, smoking years, and Brinkman Index (BI) as calculated by multiplying the number of cigarettes smoked per day by the smoking years. Counts of CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes were strongly and positively correlated with BI and remained highly significant after controlling for alcohol drinking, leisure-time physical activity, and caffeine intake (r(p)>.465, p<.001). These lymphocytes were also significantly correlated with the number of cigarettes smoked per day and smoking years, but the association was weaker than the BI. The findings suggest that the CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes are sensitive to cumulative effect of smoking, and may serve as a potential immuno-biomarker for active smoking. [Description provided by NIOSH]
• Subjects:
  Alcoholic Beverages Biomarkers Hematologic Tests Men Occupational Health Safety Smokers
• Keywords:
  Alcoholic-beverages Blood-analysis Exposure-levels Immune-system Immunological-tests Physical-exercise Smoking Time-weighted-average-exposure
• ISSN:
  0306-4603
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  7
• NIOSHTIC Number:
  nn:20032317
• Citation:
  Addict Behav 2007 Jul; 32(7):1526-1531
• Contact Point Address:
  A Nakata, National Institute for Occupational Safety and Health, MS-C24, 4676 Columbia Parkway, Cincinnati, OH 45226
• Email:
  nakataa-tky@umin.ac.jp
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  All Sectors
• Peer Reviewed:
  True
• Source Full Name:
  Addictive Behaviors
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1ec36e3e3b101a0ed37a89142046a645ca99ec422374d72d5c50a0bc3c01a2a27c1737f16d9470656ed378a908a5dd4f6337594b8cc7db927c43e3f68cef4a5f
• Download URL:
  https://stacks.cdc.gov/view/cdc/186340/cdc_186340_DS1.pdf
• File Type:
  [PDF - 450.69 KB ]