Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic. Comparison with cases of unknown etiology.

Details

• Personal Author:
  Falk H ; Popper H ; Selikoff IJ ; Telles NC ; Thomas LB
• Description:
  Studies on the induction of hepatic angiosarcoma in man by vinyl- chloride (75014), thorium-dioxide (1314201) (Thorotrast), and inorganic arsenic (7440382) were summarized. Epidemiological and histological data on biopsies from 167 cases of hepatic angiosarcoma, 128 males including four children, were examined. Nineteen cases were known to have exposure to vinyl-chloride, 28 to Thorotrast, and five to Fowler's solution (a medicinal arsenical). The etiology of the other cases was unknown. The same general patterns of development were seen in all cases, independent of the etiology. The most prominent feature of Thorotrast associated lesions was deposition of large amounts of Thorotrast in dense connective tissue in the capsule, portal tracts, and parenchyma. Proliferation of bile ductules was absent or rarely seen, in contrast to the cases resulting from vinyl-chloride and arsenical exposure. Development of hepatic angiosarcoma was characterized by a precursor stage in which hepatocytic proliferation occurred in association with varying degrees of sinusoidal lining cell proliferation and sinusoidal dilatation. In the transition to angiosarcoma, five processes were involved in varying degrees: proliferation with increasing anaplasia of intralobular endothelial cells, initial hyperplasia of hepatocytes followed by atrophy and disappearance, increasing fibrosis in perisinusoidal spaces, progression of sinusoidal dilatation to peliosis, and sarcomatous transformation of lining cells of sinusoids and portal capillaries. The authors suggest that the uniform evolution indicates that an environmental factor is involved in the cases of unknown etiology. [Description provided by NIOSH]
• Subjects:
  Cytology Digestive System Digestive System Diseases Epidemiology Liver Neoplasms Nervous System Occupational Health Safety
• Keywords:
  Contract-210-75-0044 Cytopathology Histomorphology Histopathology Humans Liver-disorders Liver-tumors Malignant-neoplasms Neoplastic-agents NIOSH-Contract NIOSH-Publication

  More +
• ISSN:
  0002-9440
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  349-369
• Volume:
  92
• Issue:
  2
• NIOSHTIC Number:
  nn:00168288
• Citation:
  Am J Pathol 1978 Aug; 92(2):349-369
• Contact Point Address:
  Louis B Thomas, MID. Chief, Laboratory of Pathology, National Cancer Institute, NIH, Building 10, Room 2A2, Bethesda, MD 20014
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Thorium oxide (ThO2) (CAS RN 1314-20-1) ; Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  1978
• Peer Reviewed:
  True
• Source Full Name:
  The American Journal of Pathology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:40c19485349bf4b3f64c68927da9a96c7edd2910597022423572dba0d3c804941bc3814a225ccdd92e29e1f76cdfdb5df7df9eed3fad7ee9aafacf062a319240
• Download URL:
  https://stacks.cdc.gov/view/cdc/185173/cdc_185173_DS1.pdf
• File Type:
  [PDF - 5.69 MB ]