Lead toxicity in mice with genetically different levels of d-aminolevulinic acid dehydratase.

Details

• Personal Author:
  Garber B ; Wei E
• Description:
  Lead is administered to three strains of mice with genetically different delta-aminolevulinic acid (ALA) dehydratase levels to elucidate the relationship of the enzyme to parameters of acute and subacute lead toxicity. Data are given for the lethal dose-50 of lead nitrate for the mice with different levels of ALA dehydratase activity, and for subacute lead toxicity in mice fed a 4% lead carbonate diet, using body weight, liver and kidney weight, hematocrit, and enzyme inhibition as indices. Results indicate that inhibition of ALA dehydratase activity is not related to acute or subacute lead toxicity as measured by physiological parameters. [Description provided by NIOSH]
• Subjects:
  Enzymes Hazardous Substances Lead Lead Poisoning Metals Occupational Health Poisoning Safety
• Keywords:
  Acute-poisoning Bioassay Enzyme-activity Lead-poisoning Metal-poisoning NIOSH-Grant NIOSH-Publication Pharmacology Porphyrin-synthesis Sulfhydryl-enzymes Toxic-substances

  More +
• ISSN:
  0007-4861
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  80-83
• Volume:
  9
• Issue:
  2
• NIOSHTIC Number:
  nn:00023277
• Citation:
  Bull Environ Contam Toxicol 1973 Feb; 9(2):80-83
• Contact Point Address:
  Public Health University of California 108 Earl Warren Hall Berkeley, Calif 94720
• CAS Registry Number:
  5-Aminolevulinic acid (CAS RN 106-60-5) ; Lead (CAS RN 7439-92-1) ; Lead carbonate (PbCO3) (CAS RN 598-63-0) ; Lead nitrate (CAS RN 10099-74-8)
• Federal Fiscal Year:
  1973
• Performing Organization:
  University of California Berkeley, Berkeley, California
• Peer Reviewed:
  True
• Start Date:
  19710701
• Source Full Name:
  Bulletin of Environmental Contamination and Toxicology
• End Date:
  19820831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad7e292ca53d9befd68a25fdcc5f44cec926b9c17239cf3293df27fd27a51e34749f3e64a46fcba6d9a736c68d051195e709d97662e1f44cf82bc5bd22bc086c
• Download URL:
  https://stacks.cdc.gov/view/cdc/183855/cdc_183855_DS1.pdf
• File Type:
  [PDF - 196.19 KB ]