Genetics and Pathogenesis of Feline Infectious Peritonitis Virus

Brown, Meredith A.; Troyer, Jennifer L.; Pecon-Slattery, Jill; Roelke, Melody E.; O’Brien, Stephen J.

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Genetics and Pathogenesis of Feline Infectious Peritonitis Virus

Sep 2009
By Brown, Meredith A. ; Troyer, Jennifer L. ; Pecon-Slattery, Jill ; ...
Source: Emerg Infect Dis. 15(9):1445-1452.

[PDF-610.01 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Brown, Meredith A. ; Troyer, Jennifer L. ; Pecon-Slattery, Jill ; Roelke, Melody E. ; O’Brien, Stephen J.

Brown, Meredith A. ; Troyer, Jennifer L. ; Pecon-Slattery, Jill ; Roelke, Melody E. ; O’Brien, Stephen J. Less -
Description:

Feline coronavirus (FCoV) is endemic in feral cat populations and cat colonies, frequently preceding outbreaks of fatal feline infectious peritonitis (FIP). FCoV exhibits 2 biotypes: the pathogenic disease and a benign infection with feline enteric coronavirus (FECV). Uncertainty remains regarding whether genetically distinctive avirulent and virulent forms coexist or whether an avirulent form mutates in vivo, causing FIP. To resolve these alternative hypotheses, we isolated viral sequences from FCoV-infected clinically healthy and sick cats (8 FIP cases and 48 FECV-asymptomatic animals); 735 sequences from 4 gene segments were generated and subjected to phylogenetic analyses. Viral sequences from healthy cats were distinct from sick cats on the basis of genetic distances observed in the membrane and nonstructural protein 7b genes. These data demonstrate distinctive circulating virulent and avirulent strains in natural populations. In addition, 5 membrane protein amino acid residues with functional potential differentiated healthy cats from cats with FIP. These findings may have potential as diagnostic markers for virulent FIP-associated FCoV.
Subjects:

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Amino Acid Sequence Animals Cat Diseases Cats Coronavirus, Feline Evolution, Molecular Feline Infectious Peritonitis Genetic Variation Membrane Proteins Molecular Sequence Data Mutation Phylogeny Research RNA, Viral Sequence Analysis, DNA Virulence
Source:

Emerg Infect Dis. 15(9):1445-1452.
Document Type:

Journal Article
Place as Subject:

Maryland
Location:

North America
Volume:

15
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:05709f759e622ff52ba89fa93b3b088292dbc8a142585a53c701ee8407e5acb7
Download URL:

https://stacks.cdc.gov/view/cdc/17785/cdc_17785_DS1.pdf
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