Prevalence and descriptive epidemiology of Turner syndrome in the United States, 2000–2017: A report from the National Birth Defects Prevention Network

Details

• Alternative Title:
  Am J Med Genet A
• Personal Author:
  Martin-Giacalone, Bailey A. ; Lin, Angela E. ; Rasmussen, Sonja A. ; Kirby, Russell S. ; Nestoridi, Eirini ; Liberman, Rebecca F. ; Agopian, A. J. ; Carey, John C. ; Cragan, Janet D. ; Forestieri, Nina ; Leedom, Vinita ; Boyce, Aubree ; Nembhard, Wendy N. ; Piccardi, Monika ; Sandidge, Theresa ; Shan, Xiaoyi ; Shumate, Charles J. ; Stallings, Erin B. ; Stevenson, Roger ; Lupo, Philip J.
• Description:
  The lack of United States population-based data on Turner syndrome limits assessments of prevalence and associated characteristics for this sex chromosome abnormality. Therefore, we collated 2000-2017 data from seven birth defects surveillance programs within the National Birth Defects Prevention Network. We estimated the prevalence of karyotype-confirmed Turner syndrome diagnosed within the first year of life. We also calculated the proportion of cases with commonly ascertained birth defects, assessed associations with maternal and infant characteristics using prevalence ratios (PR) with 95% confidence intervals (CI), and estimated survival probability. The prevalence of Turner syndrome of any pregnancy outcome was 3.2 per 10,000 female live births (95% CI = 3.0-3.3, program range: 1.0-10.4), and 1.9 for live birth and stillbirth (≥20 weeks gestation) cases (95% CI = 1.8-2.1, program range: 0.2-3.9). Prevalence was lowest among cases born to non-Hispanic Black women compared to non-Hispanic White women (PR = 0.5, 95% CI = 0.4-0.6). Coarctation of the aorta was the most common defect (11.6% of cases), and across the cohort, individuals without hypoplastic left heart had a five-year survival probability of 94.6%. The findings from this population-based study may inform surveillance practices, prenatal counseling, and diagnosis. We also identified racial and ethnic disparities in prevalence, an observation that warrants further investigation.
• Subjects:
  Aortic Coarctation Article Birth Defects Epidemiology Ethnicity Female Humans Infant Pregnancy Prevalence Racial Groups Sex Chromosome Abnormality Turner Syndrome United States

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• Source:
  Am J Med Genet A. 191(5):1339-1349
• Pubmed ID:
  36919524
• Pubmed Central ID:
  PMC10405780
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 HD093660/HD/NICHD NIH HHSUnited States/ ; T32 CA190194/CA/NCI NIH HHSUnited States/ ; T32 GM088129/GM/NIGMS NIH HHSUnited States/
• Volume:
  191
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bb126fa390ec61af973d2eb1eddc7028a140d6686649b17c0330ca20686ea0df
• Download URL:
  https://stacks.cdc.gov/view/cdc/131789/cdc_131789_DS1.pdf
• File Type:
  [PDF - 133.14 KB ]